DDAH2 - dimethylarginine dimethylaminohydrolase 2 Gene

Homo sapiens

Also known as G6a; DDAH; NG30; DDAHII; HEL-S-277

Gene ID: 23564 | Gene type: protein coding

About DDAH2

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,727,040-31,730,263 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 188 orthologues and 1 paralogue. Ubiquitous expression in endometrium (RPKM 29.0), fat (RPKM 28.2) and 24 other tissues.

Summary

This gene encodes a dimethylarginine dimethylaminohydrolase. The encoded Enzyme functions in nitric oxide generation by regulating the cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. The protein may be localized to the mitochondria. Alternative splicing resulting in multiple transcript variants. [provided by RefSeq, Dec 2014]

DDAH2 Products(3)

mRNA	Protein	Name
NM_001303007.2	NP_001289936.1	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
NM_001303008.2	NP_001289937.1	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
NM_013974.3	NP_039268.1	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables dimethylargininase activity	IDA IDA: Inferred from direct assay	21493890	GOA
NOT enables dimethylargininase activity	IGI IGI: Inferred from genetic interaction	37296100	GOA
NOT enables dimethylargininase activity	IMP IMP: Inferred from mutant phenotype	37296100	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in citrulline metabolic process	IDA IDA: Inferred from direct assay	21493890	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDAH2 Protein Structure

Amidinotransf

0
100
200
285 a.a.

Protein Preferred Names

Protein Names

N(G),N(G)-dimethylarginine dimethylaminohydrolase 2

S-phase protein

DDAH2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DDAH2	O95865	IGFN1	Homo sapiens	Q86VF2-5	Validated Y2H	32296183
Intra	DDAH2	O95865	NOXA1	Homo sapiens	Q86UR1-2	Validated Y2H	32296183
Intra	DDAH2	O95865	FANCL	Homo sapiens	Q9NW38	Validated Y2H	32296183
Cross	DDAH2	O95865	P0C6X7-PRO_0000037314	Human SARS coronavirus	P0C6X7-PRO_0000037314	Y2H Pooling	22046132
Cross	DDAH2	O95865	P0C6X7-PRO_0000037314	Human SARS coronavirus	P0C6X7-PRO_0000037314	Lumier	22046132
Intra	DDAH2	O95865	ACTN3	Homo sapiens	Q08043	Validated Y2H	32296183
Intra	DDAH2	O95865	TRIP13	Homo sapiens	Q15645	Y2H Prey Pooling	32296183
Intra	DDAH2	O95865	TRIP13	Homo sapiens	Q15645	Validated Y2H	32296183
Intra	DDAH2	O95865	TRIP13	Homo sapiens	Q15645	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Chronic Kidney Disease

Chronic Renal Disease	Chronic Kidney Failure
Ckd	Chronic Renal Failure
Kidney Failure, Chronic	Chronic Renal Failure Syndrome
Crf	Renal Failure - Chronic
Renal Failure Chronic	Chronic Kidney Diseases
Chronic Kidney Disease Stage 5	Ckd - [Chronic Kidney Disease]
Crf - [Chronic Renal Failure]	Chronic Kidney Impairment
Chronic Renal Impairment	Chronic Kidney Shutdown
Chronic Hypoxic Kidney Failure	Chronic Kidney Collapse
Chronic Renal Insufficiency	Chronic Kidney Toxaemia
Chronic Kidney Hypofunction	Chronic Renal Suppression
Chronic Renal Failure, Stage 5	Ckd - [Chronic Kidney Disease] Stage 5
End Stage Kidney Failure	End Stage Renal Failure
End Stage Kidney Disease	End Stage Renal Disease
End Stage Chronic Renal Failure	Esrf - [End Stage Renal Failure]
Esrd - [End Stage Renal Diseases]	Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²

Pre-Eclampsia

Preeclampsia	Gestational Hypertension
Hypertension Induced By Pregnancy	Pre-Eclamptic Toxaemia
Pregnancy Associated Hypertension	Proteinuric Hypertension Of Pregnancy
Hypertension, Pregnancy-Induced, Susceptibility To	Preeclampsia/Eclampsia
Pregnancy Toxemia	Toxaemia Of Pregnancy
Gestational Proteinuric Hypertension	Pregnancy-Induced Hypertension
Toxemia Of Pregnancy	Preeclampsia, Susceptibility To
Transient Hypertension Of Pregnancy	Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria
Gestational Hypertension Nos	Mild Proteinuric Hypertension Of Pregnancy
Pih - [Pregnancy-Induced Hypertension]	Pregnancy-Induced Hypertension Nos
Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria	Pe - [Pre-Eclampsia]
Pre-Eclampsia Nos	Pre-Eclamptic Nos
Pregnancy Pre-Eclampsia	Puerperal Pre-Eclampsia
Pre-Eclampsia Toxaemia	Toxaemia In Pregnancy
Pet - [Pre-Eclamptic Toxaemia]	Maternal Toxaemia

Cardiovascular System Disease

Abnormality Of The Cardiovascular System	Cardiovascular Disease
Disease Of Subdivision Of Hemolymphoid System	Disorder Of Cardiovascular System
Cardiovascular Diseases

Arteriosclerosis

Arteriosclerotic Vascular Disease

Pulmonary Hypertension

Primary Pulmonary Hypertension	Hypertension Pulmonary
Hypertension, Pulmonary	Hypertension, Pulmonary, Primary
Idiopathic Pulmonary Hypertension	Idiopathic Pulmonary Arterial Hypertension
Pulmonary Htn - [Hypertension]

Esophageal Lipoma

Lipoma Of Esophagus

Diabetes Mellitus

Diabetes

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03605	DDAH2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DDAH2	MGD	MGI:1859016
Macaca mulatta	DDAH2	VGNC	VGNC:81057
Canis familiaris	DDAH2	VGNC	VGNC:39828
Bos taurus	DDAH2	VGNC	VGNC:27940
Felis catus	DDAH2	VGNC	VGNC:61385
Rattus norvegicus	DDAH2	RGD	RGD:1302955

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