FPR2 - formyl peptide receptor 2 Gene

Homo sapiens

Also known as ALX; ALXR; HM63; FMLPX; FPR2A; FPRH1; FPRH2; FPRL1; LXA4R; FMLP-R-II

Gene ID: 2358 | Gene type: protein coding

About FPR2

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,761,180-51,770,531 (from NCBI)

This gene has 6 transcripts (splice variants), 140 orthologues and 8 paralogues. Biased expression in appendix (RPKM 23.5), spleen (RPKM 4.6) and 5 other tissues.

Summary

Enables amyloid-beta binding activity; scavenger receptor binding activity; and signaling receptor activity. Involved in several processes, including cellular response to amyloid-beta; positive regulation of monocyte chemotaxis; and regulation of defense response. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

FPR2 Products(2)

mRNA	Protein	Name
NM_001005738.2	NP_001005738.1	N-formyl peptide receptor 2
NM_001462.3	NP_001453.1	N-formyl peptide receptor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	11316806	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15465011	GOA
enables scavenger receptor binding	IPI IPI: Inferred from physical interaction	20141570	GOA
enables signaling receptor activity	IDA IDA: Inferred from direct assay	25505240	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IGI IGI: Inferred from genetic interaction	11160457	GOA
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IGI IGI: Inferred from genetic interaction	20141570	GOA
involved in calcium-mediated signaling	IGI IGI: Inferred from genetic interaction	11160457	GOA
involved in cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	25505240	GOA
involved in cellular response to amyloid-beta	IDA IDA: Inferred from direct assay	11316806	GOA
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	25505240	GOA
involved in immune response-regulating cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	25505240	GOA
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	25505240	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	20141570	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	20141570	GOA
involved in positive regulation of innate immune response	IDA IDA: Inferred from direct assay	25505240	GOA
involved in positive regulation of monocyte chemotaxis	IGI IGI: Inferred from genetic interaction	11160457	GOA
involved in positive regulation of phagocytosis	IDA IDA: Inferred from direct assay	25505240	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11689470	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11689470	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FPR2 Protein Structure

7tm_1

0
100
200
300
351 a.a.

Protein Preferred Names

Protein Names

N-formyl peptide receptor 2

FMLP-R-I

FPR2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FPR2	P25090	LRRC25	Homo sapiens	Q8N386	Y2H Prey Pooling	32296183
Intra	FPR2	P25090	LRRC25	Homo sapiens	Q8N386	Validated Y2H	32296183
Intra	FPR2	P25090	LRRC25	Homo sapiens	Q8N386	Y2H Array	32296183
Intra	FPR2	P25090	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
Intra	FPR2	P25090	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	FPR2	P25090	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	FPR2	P25090	FXYD6	Homo sapiens	Q9H0Q3	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Diamond-Blackfan Anemia 2

DBA2	Anemia, Diamond-Blackfan, 2
Anemia Diamond-Blackfan 2

Prion Disease

Spongiform Encephalopathy	Transmissible Spongiform Encephalopathies
Prion Diseases	Prion Disease Pathway
Transmissible Spongiform Encephalopathy	Prion Induced Disorder
Prion Protein Disease	Inherited Human Transmissible Spongiform Encephalopathies
Prion Protein Diseases	Prion-Associated Disorders
Prion-Induced Disorders	Transmissible Dementias
Tses	Human Prion Disease
Tse	Encephalopathy, Transmissible Spongiform
Prion Disease, Susceptibility To	Spongiform Encephalopathies
Human Transmissible Spongiform Encephalopathies, Inherited

Severe Congenital Neutropenia 2

Scn2

Anaerobic Meningitis

Bacterial Infectious Disease

Bacterial Infections	Bacterial Infection Nos
Disease Caused By Bacteria	Bacterial Disease Or Disorder

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-131180	BMS-986235		99.48%	Phase 1
HY-124071	ACT-389949		99.96%	Phase 1

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1120	WKYMVm		99.88%	Unkown
HY-103286	PD176252	Antagonist	99.38%	Unkown
HY-116216	PD 168368	Antagonist	≥99.0%	Unkown
HY-19574	FPR Agonist 43		99.79%	Unkown
HY-P1116A	PBP10 TFA	Inhibitor	98.14%	Unkown
HY-110246	Quin C1		98.47%	Unkown
HY-144604	FPR2 agonist 2	Agonist	99.59%	Unkown
HY-155335	FPR2 agonist 3	Agonist	99.39%	Unkown
HY-P1117	MMK1		99.22%	Unkown
HY-P1744	N-Formyl-Met-Leu-Phe-Lys		98.98%	Unkown
HY-P1120A	WKYMVm TFA		/	Unkown
HY-159583	FPR2 agonist 4	Agonist	/	Unkown
HY-P10432	SHAAGtide	Activator	/	Unkown
HY-P1116	PBP10	Inhibitor	/	Unkown
HY-P1117A	MMK1 TFA		/	Unkown
HY-RS05086	FPR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FPR2	MGD	MGI:1278319
Rattus norvegicus	FPR2	RGD	RGD:1584013
Macaca mulatta	FPR2	VGNC	VGNC:109506

Name
Email *

	Sorry, but the email address you supplied was invalid.