2. GPCR/G Protein Cell Cycle/DNA Damage Apoptosis
  3. Formyl Peptide Receptor (FPR) PERK Apoptosis
  4. WKYMVm

WKYMVm is a selective formylpeptide receptor 2 (FPR2) agonist. WKYMVm has a powerful anti-inflammatory effect that can reduce lung injury and spinal cord injury. WKYMVm ameliorates obesity by regulating lipid metabolism and leptin signaling. WKYMVm is involved in the regulation of immune cells by activating FPRs. WKYMVm can promote the chemotactic migration of immune cells and inhibit the apoptosis of phagocytes. In addition, WKYMVm may play a favorable or unfavorable role in tumors, depending on the type of tumor.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

WKYMVm Chemical Structure

WKYMVm Chemical Structure

CAS No. : 187986-17-0

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1 mg USD 140 In-stock
5 mg USD 350 In-stock
10 mg USD 560 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of WKYMVm:

WKYMVm Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

WKYMVm is a selective formylpeptide receptor 2 (FPR2) agonist. WKYMVm has a powerful anti-inflammatory effect that can reduce lung injury and spinal cord injury. WKYMVm ameliorates obesity by regulating lipid metabolism and leptin signaling. WKYMVm is involved in the regulation of immune cells by activating FPRs. WKYMVm can promote the chemotactic migration of immune cells and inhibit the apoptosis of phagocytes. In addition, WKYMVm may play a favorable or unfavorable role in tumors, depending on the type of tumor[1][2][3][4][5][6][7].

IC50 & Target

FPR1, FPRL1[1], FPRL2[2]
Cellular Effect
Cell Line Type Value Description References
HL-60 EC50
0.001 μM
Compound: WKYMVm
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
[PMID: 19639995]
HL-60 EC50
0.01 μM
Compound: WKYMVm
Agonist activity at FPRL2 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
Agonist activity at FPRL2 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
[PMID: 19639995]
HL-60 EC50
0.5 μM
Compound: WKYMVm
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
[PMID: 19639995]
In Vitro

WKYMVm (0-5 μmol/L; 2 h) inhibits the production of inflammatory cytokines (TNF-α, IL-6 and IL-1β) in LPS (HY-D1056) treated microglia [3].
WKYMVm (1-100 µM; 0-24 h) can increase FPR2 mRNA level and ERK phosphorylation level in HUVECs cells, promote HUVECs tube formation and cell proliferation[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

WKYMVm Related Antibodies
In Vivo

WKYMVm (4 mg/kg; Intraperitoneal injection; 3 times; 24 h interval) has a protective effect in rat spinal cord injury model[3].
WKYMVm (2.5 mg/kg; Intraperitoneal injection; 4 days) can alleviate hyperoxy-induced lung injury in neonatal mice[4].
WKYMVm (8 mg/kg; Subcutaneous injection; Once every two days; 2-5 weeks) improves obesity in high-fat fed mouse models[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult female Sprague-Dawley rats (200-220 g) with spinal cord injury[3]
Dosage: 4 mg/kg
Administration: Intraperitoneal injection (i.p.); 3 times with 24 hours intervals
Result: Reduce structural disorders and neuronal loss.
Reduced the phosphorylation of ERK1/2 and NF-κB p65 but not p38.
Animal Model: Normoxia or hyperoxic treated newborn mouse pups of C57/BL6[4]
Dosage: 2.5 mg/kg
Administration: Intraperitoneal injection (i.p.); daily from postnatal day (P) 5 to P8.
Result: Significantly attenuated hyperoxia-induced lung inflammation, as evidenced by increased inflammatory cytokines, neutrophils, and alveolar macrophages, and resultant lung injuries, which included impaired alveolarization and angiogenesis, an increased number of apoptotic cells, and reduced levels of growth factors in vivo, such as vascular endothelial growth factor and hepatocyte growth factor.
Animal Model: High fat diet treated male wild-type C57BL/6N mice aged 8 weeks old (21 ± 2 g)[5]
Dosage: 8 mg/kg
Administration: Subcutaneous injection (i.h.); once every 2 days; 2 or 5 weeks
Result: Significantly attenuated body weight gain, food intake and increased insulin sensitivity.
Markedly ameliorated HFD-induced hepatic steatosis and adipose tissue hypertrophy.
Improved lipid metabolism in adipose tissue.
Improved leptin signalling in the hypothalamus.
Molecular Weight

856.11

Formula

C41H61N9O7S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Trp-Lys-Tyr-Met-Val-{d-Met}-NH2
Sequence Shortening

WKYMV-{d-Met}-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 12.5 mg/mL (14.60 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1681 mL 5.8404 mL 11.6807 mL
5 mM 0.2336 mL 1.1681 mL 2.3361 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.1681 mL 5.8404 mL 11.6807 mL 29.2019 mL
5 mM 0.2336 mL 1.1681 mL 2.3361 mL 5.8404 mL
10 mM 0.1168 mL 0.5840 mL 1.1681 mL 2.9202 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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WKYMVm Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WKYMVm187986-17-0Formyl Peptide Receptor (FPR)PERKApoptosisProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseMicrogliaHUVECsSpinal cord injury modelHigh-fat fed mouse modelFormyl Peptide Receptor AgonistInhibitorinhibitorinhibit

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