2. Gene
  3. SMUG1 - single-strand-selective monofunctional uracil-DNA glycosylase 1 Gene

SMUG1 - single-strand-selective monofunctional uracil-DNA glycosylase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FDG; UNG3; HMUDG

Gene ID: 23583 | Gene type: protein coding

About SMUG1

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:54,158,235-54,188,985 (from NCBI)

This gene has 26 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in skin (RPKM 3.7), placenta (RPKM 3.4) and 25 other tissues.

Summary

This gene encodes a protein that participates in base excision repair by removing uracil from single- and double-stranded DNA. Many alternatively spliced transcript variants exist for this gene; the full-length nature is known for some but not all of the variants. [provided by RefSeq, Aug 2011]

SMUG1 Products(32)

mRNA Protein Name
NM_001243787.2 NP_001230716.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001243788.2 NP_001230717.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001243789.2 NP_001230718.1 single-strand selective monofunctional uracil DNA glycosylase isoform 2
NM_001243790.2 NP_001230719.1 single-strand selective monofunctional uracil DNA glycosylase isoform 2
NM_001243791.2 NP_001230720.1 single-strand selective monofunctional uracil DNA glycosylase isoform 2
NM_001351237.2 NP_001338166.1 single-strand selective monofunctional uracil DNA glycosylase isoform 2
NM_001351238.2 NP_001338167.1 single-strand selective monofunctional uracil DNA glycosylase isoform 2
NM_001351239.2 NP_001338168.1 single-strand selective monofunctional uracil DNA glycosylase isoform 2
NM_001351240.2 NP_001338169.1 single-strand selective monofunctional uracil DNA glycosylase isoform 2
NM_001351241.2 NP_001338170.1 single-strand selective monofunctional uracil DNA glycosylase isoform 2
NM_001351242.2 NP_001338171.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351243.2 NP_001338172.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351244.2 NP_001338173.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351245.2 NP_001338174.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351246.2 NP_001338175.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351247.2 NP_001338176.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351248.2 NP_001338177.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351249.2 NP_001338178.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351250.2 NP_001338179.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351251.2 NP_001338180.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351252.2 NP_001338181.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351253.2 NP_001338182.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351254.2 NP_001338183.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351255.2 NP_001338184.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351256.2 NP_001338185.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351257.2 NP_001338186.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_001351258.2 NP_001338187.1 single-strand selective monofunctional uracil DNA glycosylase isoform 3
NM_001351259.2 NP_001338188.1 single-strand selective monofunctional uracil DNA glycosylase isoform 4
NM_001351260.2 NP_001338189.1 single-strand selective monofunctional uracil DNA glycosylase isoform 4
NM_001351261.2 NP_001338190.1 single-strand selective monofunctional uracil DNA glycosylase isoform 5
NM_001351262.2 NP_001338191.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1
NM_014311.3 NP_055126.1 single-strand selective monofunctional uracil DNA glycosylase isoform 1

SMUG1 Protein Structure

UDG

UDG: Uracil DNA glycosylase superfamily (71 - 262)

  • 0
  • 100
  • 200
  • 270 a.a.
Protein Preferred Names Protein Names

single-strand selective monofunctional uracil DNA glycosylase

Recombinant SMUG1 Proteins

Cat. No. Product Name Accession Purity
HY-P71560 SMUG1 Protein, Human (His-SUMO) Q53HV7 (1M-177L) ≥95%

Related Diseases

Diseases Alias
Rectosigmoid Junction Neoplasm

Neoplasm Of Rectosigmoid Junction

Rectosigmoid Neoplasm

Rectosigmoid Tumor

Rectosigmoid Carcinoma

Carcinoma Of The Rectosigmoid Junction

Malignant Tumor Of Rectosigmoid Junction

Rectosigmoid Junction Cancer

Primary Malignant Neoplasm Of Rectosigmoid Junction

Rectosigmoid Colon Cancer

Carcinoma Of Rectum With Sigmoid

Colorectal Cancer Nos

Colorectal Carcinoma Nos

Rectosigmoid Cancer
Immunodeficiency With Hyper-Igm, Type 5

HIGM5

Hyper-Igm Syndrome 5

Immunodeficiency With Hyper Igm Type 5

Hyper-Igm Syndrome Type 5

Hyper-Igm Syndrome Due To Ung Deficiency

Hyper-Igm Syndrome Due To Uracil N-Glycosylase

Immunodeficiency With Hyper Igm, Type 5

Hyper Igm Syndrome 5

Immunodeficiency With Hyper-Igm 5

Hyper-Igm Immunodeficiency Type 5

Immunodeficiency, With Hyper Igm, Type 5

Hyper-Igm Immunodeficiency Syndrome, Type 5
Sigmoid Neoplasm

Sigmoid Neoplasms

Neoplasm Of Sigmoid Colon

Tumor Of Sigmoid Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13458 SMUG1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SMUG1 VGNC VGNC:65509
Rattus norvegicus SMUG1 RGD RGD:631403
Mus musculus SMUG1 MGD MGI:1918976
Bos taurus SMUG1 VGNC VGNC:35039
Macaca mulatta SMUG1 VGNC VGNC:77730
Canis familiaris SMUG1 VGNC VGNC:46579
Others SMUG1 NCBI