ELP5 - elongator acetyltransferase complex subunit 5 Gene

Homo sapiens

Also known as DERP6; MST071; HSPC002; MSTP071; C17orf81

Gene ID: 23587 | Gene type: protein coding

About ELP5

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,251,724-7,259,940 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele and 177 orthologues. Broad expression in testis (RPKM 39.1), brain (RPKM 8.9) and 24 other tissues.

Summary

Predicted to contribute to tRNA binding activity. Predicted to be involved in positive regulation of cell migration and tRNA modification. Located in cytosol and nucleoplasm. Part of elongator holoenzyme complex. [provided by Alliance of Genome Resources, Apr 2022]

ELP5 Products(4)

mRNA	Protein	Name
NM_015362.5	NP_056177.4	elongator complex protein 5 isoform 1
NM_203413.3	NP_981958.2	elongator complex protein 5 isoform 2
NM_203414.3	NP_981959.2	elongator complex protein 5 isoform 1
NM_203415.4	NP_981960.2	elongator complex protein 5 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	22854966	GOA
part of elongator holoenzyme complex	IDA IDA: Inferred from direct assay	22854966	GOA
part of elongator holoenzyme complex	IPI IPI: Inferred from physical interaction	22854966	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22854966	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELP5 Protein Structure

Elong_Iki1

0
100
200
316 a.a.

Protein Preferred Names

Protein Names

elongator complex protein 5

S-phase 2 protein

ELP5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ELP5	Q8TE02	ELP6	Homo sapiens	Q0PNE2	Anti Tag CoIP	22854966
Intra	ELP5	Q8TE02	ELP4	Homo sapiens	Q96EB1	Anti Tag CoIP	22854966

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Tomato Allergy

Solanum Lycopersicum Fruit Allergy

Neuropathy, Hereditary Sensory And Autonomic, Type Iii

Familial Dysautonomia	Riley-Day Syndrome
Dysautonomia, Familial	HSAN3
Hsan Iii	Fd
Hereditary Sensory And Autonomic Neuropathy Type Iii	Dys
Hereditary Sensory And Autonomic Neuropathy 3	Riley Day Syndrome
Familial Autonomic Nervous Dysfunction	Hereditary Sensory Autonomic Neuropathy Type Iii
Hsan 3	Hsn 3
Hereditary Sensory Neuropathy Type 3	Hsan Type Iii
Hsn-Iii	Hereditary Sensory And Autonomic Neuropathy Type 3
Neuropathy, Hereditary Sensory And Autonomic, 3	Hsn Iii
Dysautonomia Familial	Neuropathy, Sensory And Autonomic, Hereditary, Type Iii
Hsan3 - [Hereditary Sensory And Autonomic Neuropathy Type 3]

Benign Epilepsy With Centrotemporal Spikes

Rolandic Epilepsy	Benign Rolandic Epilepsy
Epilepsy, Rolandic	Bcects
Benign Childhood Epilepsy With Centrotemporal Spike	Sylvan Seizures
Becrs	Bects
Bre	Benign Epilepsy Of Childhood With Centrotemporal Spikes
Benign Familial Epilepsy Of Childhood With Rolandic Spikes	Centrotemporal Epilepsy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04332	ELP5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ELP5	VGNC	VGNC:72146
Bos taurus	ELP5	VGNC	VGNC:28458
Mus musculus	ELP5	MGD	MGI:1859017
Canis familiaris	ELP5	VGNC	VGNC:40329
Felis catus	ELP5	VGNC	VGNC:61829
Rattus norvegicus	ELP5	RGD	RGD:1303303

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