ELP6 - elongator acetyltransferase complex subunit 6 Gene

Homo sapiens

Also known as C3orf75; TMEM103

Gene ID: 54859 | Gene type: protein coding

About ELP6

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:47,495,640-47,513,712 (from NCBI)

This gene has 15 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in testis (RPKM 3.4), adrenal (RPKM 3.4) and 25 other tissues.

Summary

Predicted to be involved in positive regulation of cell migration. Located in cytosol and nucleus. Part of elongator holoenzyme complex. [provided by Alliance of Genome Resources, Apr 2022]

ELP6 Products(2)

mRNA	Protein	Name
NM_001031703.3	NP_001026873.2	elongator complex protein 6 isoform 1
NM_001363957.1	NP_001350886.1	elongator complex protein 6 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22854966	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	22645656	GOA
part of elongator holoenzyme complex	IDA IDA: Inferred from direct assay	22854966	GOA
part of elongator holoenzyme complex	IPI IPI: Inferred from physical interaction	22854966	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22645656	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELP6 Protein Structure

ELP6

0
100
200
266 a.a.

Protein Preferred Names

Protein Names

elongator complex protein 6

UPF0405 protein C3orf75

ELP6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ELP6	Q0PNE2	ELP5	Homo sapiens	Q8TE02	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lipid Pneumonia

Exogenous Lipoid Pneumonia	Lipoid Pneumonitis
Pneumonia, Lipid	Pneumonia Lipid
Lipoid Pneumonia

Neuropathy, Hereditary Sensory And Autonomic, Type Iii

Familial Dysautonomia	Riley-Day Syndrome
Dysautonomia, Familial	HSAN3
Hsan Iii	Fd
Hereditary Sensory And Autonomic Neuropathy Type Iii	Dys
Hereditary Sensory And Autonomic Neuropathy 3	Riley Day Syndrome
Familial Autonomic Nervous Dysfunction	Hereditary Sensory Autonomic Neuropathy Type Iii
Hsan 3	Hsn 3
Hereditary Sensory Neuropathy Type 3	Hsan Type Iii
Hsn-Iii	Hereditary Sensory And Autonomic Neuropathy Type 3
Neuropathy, Hereditary Sensory And Autonomic, 3	Hsn Iii
Dysautonomia Familial	Neuropathy, Sensory And Autonomic, Hereditary, Type Iii
Hsan3 - [Hereditary Sensory And Autonomic Neuropathy Type 3]

Vasomotor Rhinitis

Rhinitis, Vasomotor	Rhinitis Vasomotor
Vmr - [Vasomotor Rhinitis]

Hereditary Sensory Neuropathy

Hereditary Sensory And Autonomic Neuropathy	Hereditary Sensory And Autonomic Neuropathies
Familial Dysautonomia, Type Ii	Hsan
Sensory Neuropathy Hereditary	Neuropathy, Sensory And Autonomic, Hereditary
Neuropathy, Sensory, Hereditary	Sensory Neuropathy, Hereditary
Charcot-Marie-Tooth Disease	Cmt - [Charcot-Marie-Tooth Disease]

Benign Epilepsy With Centrotemporal Spikes

Rolandic Epilepsy	Benign Rolandic Epilepsy
Epilepsy, Rolandic	Bcects
Benign Childhood Epilepsy With Centrotemporal Spike	Sylvan Seizures
Becrs	Bects
Bre	Benign Epilepsy Of Childhood With Centrotemporal Spikes
Benign Familial Epilepsy Of Childhood With Rolandic Spikes	Centrotemporal Epilepsy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04333	ELP6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ELP6	MGD	MGI:1919349
Bos taurus	ELP6	VGNC	VGNC:28459
Felis catus	ELP6	VGNC	VGNC:61830
Rattus norvegicus	ELP6	RGD	RGD:1305478
Macaca mulatta	ELP6	VGNC	VGNC:72113
Canis familiaris	ELP6	VGNC	VGNC:49826

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