2. Gene
  3. ORC3 - origin recognition complex subunit 3 Gene

ORC3 - origin recognition complex subunit 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LAT; ORC3L; LATHEO

Gene ID: 23595 | Gene type: protein coding

About ORC3

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:87,590,135-87,677,823 (from NCBI)

This gene has 7 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in testis (RPKM 9.4), adrenal (RPKM 6.1) and 25 other tissues.

Summary

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

ORC3 Products(3)

mRNA Protein Name
NM_001197259.2 NP_001184188.1 origin recognition complex subunit 3 isoform 3
NM_012381.4 NP_036513.2 origin recognition complex subunit 3 isoform 2
NM_181837.3 NP_862820.1 origin recognition complex subunit 3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15232106 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA replication initiation IDA
IDA: Inferred from direct assay
16549788 GOA
involved in regulation of DNA replication IDA
IDA: Inferred from direct assay
31160578 GOA
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
31160578 GOA
part of nuclear origin of replication recognition complex IDA
IDA: Inferred from direct assay
20932478 GOA
part of nuclear origin of replication recognition complex IPI
IPI: Inferred from physical interaction
16549788 GOA
part of origin recognition complex IDA
IDA: Inferred from direct assay
17716973 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ORC3 Protein Structure

ORC3_N

ORC3_N: Origin recognition complex (ORC) subunit 3 N-terminus (17 - 344)

  • 0
  • 200
  • 400
  • 600
  • 711 a.a.
Protein Preferred Names Protein Names

origin recognition complex subunit 3

homolog of latheo, Drosophila

ORC3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ORC3 Q9UBD5 ORC6 Homo sapiens Q9Y5N6
Anti Bait CoIP
17716973
Intra
ORC3 Q9UBD5 ORC1 Homo sapiens Q13415
Anti Bait CoIP
17716973
Intra
ORC3 Q9UBD5 ORC4 Homo sapiens O43929
Anti Bait CoIP
17716973
Intra
ORC3 Q9UBD5 ORC5 Homo sapiens O43913
Protein Array
15232106
Intra
ORC3 Q9UBD5 ORC5 Homo sapiens O43913
Anti Bait CoIP
17716973
Intra
ORC3 Q9UBD5 ORC2 Homo sapiens Q13416
Anti Bait CoIP
17716973
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Van Esch-O'Driscoll Syndrome

X-Linked Intellectual Disability, Van Esch Type

VEODS

Mrxsveod

Mental Retardation, X-Linked, Syndromic, Van Esch-O'Driscoll Type

X-Linked Syndromic Mental Retardation Van Esch-O'Driscoll Type
Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome

Ear, Patella, Short Stature Syndrome

Microtia, Absent Patellae, Micrognathia Syndrome

MGORS1

Eps

Ear-Patella-Short Stature Syndrome

Ear Patella Short Stature Syndrome

Microtia Absent Patellae Micrognathia Syndrome

Meier-Gorlin Syndrome, Type 1
Isolated Growth Hormone Deficiency, Type Ia

Ighd Ia

Primordial Dwarfism

Isolated Growth Hormone Deficiency Type Ia

Sexual Ateleiotic Dwarfism

Pituitary Dwarfism I

IGHD1A

Illig-Type Growth Hormone Deficiency

Growth Hormone Deficiency, Isolated, Type Ia

Congenital Ighd Type Ia

Congenital Isolated Gh Deficiency Type Ia

Congenital Isolated Growth Hormone Deficiency Type Ia

Pituitary Dwarfism 1

Growth Hormone Deficiency, Isolated, Autosomal Recessive

Autosomal Recessive Isolated Growth Hormone Deficiency

Isolated Growth Hormone Deficiency Type 1a

Congenital Ighd

Congenital Isolated Gh Deficiency

Congenital Isolated Growth Hormone Deficiency

Growth Hormone Deficiency, Isolated Autosomal Recessive

Illig Type Growth Hormone Deficiency

Non-Acquired Isolated Growth Hormone Deficiency

Growth Hormone Deficiency, Isolated, 1a

Growth Hormone Deficiency Isolated Autosomal Recessive

Dwarfism, Primordial

Dwarfism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09827 ORC3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ORC3 VGNC VGNC:32448
Mus musculus ORC3 MGD MGI:1354944
Canis familiaris ORC3 VGNC VGNC:44142
Rattus norvegicus ORC3 RGD RGD:1308457
Felis catus ORC3 VGNC VGNC:68650
Macaca mulatta ORC3 VGNC VGNC:75715
Others ORC3 NCBI