ORC4 - origin recognition complex subunit 4 Gene

Homo sapiens

Also known as ORC4L; ORC4P

Gene ID: 5000 | Gene type: protein coding

About ORC4

Cytogenetic location: 2q23.1 Genomic coordinates (GRCh38): 2:147,930,396-148,021,551 (from NCBI)

This gene has 16 transcripts (splice variants), 211 orthologues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 7.5), skin (RPKM 6.5) and 25 other tissues.

Summary

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene. [provided by RefSeq, Oct 2010]

ORC4 Products(8)

mRNA	Protein	Name
NM_001190879.3	NP_001177808.1	origin recognition complex subunit 4 isoform 1
NM_001190881.3	NP_001177810.1	origin recognition complex subunit 4 isoform 2
NM_001190882.3	NP_001177811.1	origin recognition complex subunit 4 isoform 3
NM_001374270.1	NP_001361199.1	origin recognition complex subunit 4 isoform 1
NM_001374272.1	NP_001361201.1	origin recognition complex subunit 4 isoform 2
NM_002552.5	NP_002543.2	origin recognition complex subunit 4 isoform 1
NM_181741.4	NP_859525.1	origin recognition complex subunit 4 isoform 1
NM_181742.4	NP_859526.1	origin recognition complex subunit 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA replication origin binding	IMP IMP: Inferred from mutant phenotype	9353276	GOA
enables nucleotide binding	IDA IDA: Inferred from direct assay	9353276	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15232106	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA replication initiation	IDA IDA: Inferred from direct assay	16549788	GOA
involved in DNA replication initiation	IMP IMP: Inferred from mutant phenotype	9353276	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with chromosome, telomeric region	IDA IDA: Inferred from direct assay	24270157	GOA
part of nuclear origin of replication recognition complex	IDA IDA: Inferred from direct assay	20932478	GOA
part of nuclear origin of replication recognition complex	IPI IPI: Inferred from physical interaction	16549788	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9353276	GOA
part of origin recognition complex	IDA IDA: Inferred from direct assay	17716973	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ORC4 Protein Structure

AAA_16

ORC4_C

0
100
200
300
400
436 a.a.

Protein Preferred Names

Protein Names

origin recognition complex subunit 4

origin recognition complex, subunit 4 homolog

ORC4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ORC4	O43929	LACC1	Homo sapiens	Q8IV20	Anti Tag CoIP	33961781
Intra	ORC4	O43929	LACC1	Homo sapiens	Q8IV20	Anti Tag CoIP	28514442
Intra	ORC4	O43929	ORC6	Homo sapiens	Q9Y5N6	BiFC	18234858
Intra	ORC4	O43929	ORC3	Homo sapiens	Q9UBD5	Anti Bait CoIP	17716973
Intra	ORC4	O43929	ORC3	Homo sapiens	Q9UBD5	Protein Array	15232106
Intra	ORC4	O43929	ORC2	Homo sapiens	Q13416	Anti Bait CoIP	17716973
Intra	ORC4	O43929	TCF4	Homo sapiens	P15884	Y2H Array	25416956
Intra	ORC4	O43929	TCF4	Homo sapiens	P15884	Y2H Prey Pooling	25416956
Intra	ORC4	O43929	RRM2B	Homo sapiens	Q7LG56	Validated Y2H	25416956
Intra	ORC4	O43929	RRM2B	Homo sapiens	Q7LG56	Y2H Array	25416956
Intra	ORC4	O43929	RRM2B	Homo sapiens	Q7LG56	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Meier-Gorlin Syndrome 2

MGORS2

Meier-Gorlin Syndrome, Type 2

Mbd5 Haploinsufficiency

2q23.1 Microdeletion Syndrome	2q23.1 Microduplication Syndrome
Del(2)(Q23.1)	Monosomy 2q23.1
Pseudo-Angelman Syndrome	Mbd5 Associated Neurodevelopmental Disorder
Chromosome 2q23.1 Microdeletion Syndrome	Mbd5-Associated Neurodevelopmental Disorder
Mand	Dup(2)(Q23.1)
Trisomy 2q23.1

Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome	Ear, Patella, Short Stature Syndrome
Microtia, Absent Patellae, Micrognathia Syndrome	MGORS1
Eps	Ear-Patella-Short Stature Syndrome
Ear Patella Short Stature Syndrome	Microtia Absent Patellae Micrognathia Syndrome
Meier-Gorlin Syndrome, Type 1

Meier-Gorlin Syndrome 7

MGORS7

Meier-Gorlin Syndrome, Type 7

Meier-Gorlin Syndrome 5

MGORS5

Meier-Gorlin Syndrome, Type 5

Microtia

Congenital Small Ears

Hypoplasia Of Ear

Genitourinary Tract Anomalies

Isolated Growth Hormone Deficiency

Congenital Ighd	Congenital Isolated Gh Deficiency
Congenital Isolated Growth Hormone Deficiency	Non-Acquired Isolated Growth Hormone Deficiency
Pituitary Dwarfism	Dwarfism, Pituitary
Isolated Somatotropin Deficiency	Isolated Congenital Growth Hormone Deficiency
Familial Isolated Growth Hormone Deficiency	Ighd
Dwarfism, Growth Hormone Deficiency	Growth Hormone Deficiency Dwarfism
Isolated Gh Deficiency	Isolated Hgh Deficiency
Isolated Human Growth Hormone Deficiency	Isolated Somatotropin Deficiency Disorder
Dwarfism Pituitary

Isolated Growth Hormone Deficiency, Type Ia

Ighd Ia	Primordial Dwarfism
Isolated Growth Hormone Deficiency Type Ia	Sexual Ateleiotic Dwarfism
Pituitary Dwarfism I	IGHD1A
Illig-Type Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, Type Ia
Congenital Ighd Type Ia	Congenital Isolated Gh Deficiency Type Ia
Congenital Isolated Growth Hormone Deficiency Type Ia	Pituitary Dwarfism 1
Growth Hormone Deficiency, Isolated, Autosomal Recessive	Autosomal Recessive Isolated Growth Hormone Deficiency
Isolated Growth Hormone Deficiency Type 1a	Congenital Ighd
Congenital Isolated Gh Deficiency	Congenital Isolated Growth Hormone Deficiency
Growth Hormone Deficiency, Isolated Autosomal Recessive	Illig Type Growth Hormone Deficiency
Non-Acquired Isolated Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, 1a
Growth Hormone Deficiency Isolated Autosomal Recessive	Dwarfism, Primordial
Dwarfism

Nemaline Myopathy 2

NEM2	Nemaline Myopathy 2, Autosomal Recessive
Nemaline Myopathy, Type 2	Neb-Related Nemaline Myopathy
Myopathy, Nemaline, Type 2

Seckel Syndrome

Microcephalic Primordial Dwarfism	Bird-Headed Dwarfism
Harper'S Syndrome	Virchow-Seckel Dwarfism
Nanocephalic Dwarfism	Sckl
Seckel-Type Dwarfism

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09828	ORC4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ORC4	VGNC	VGNC:44143
Macaca mulatta	ORC4	VGNC	VGNC:75716
Felis catus	ORC4	VGNC	VGNC:68651
Mus musculus	ORC4	MGD	MGI:1347043
Rattus norvegicus	ORC4	RGD	RGD:735212
Bos taurus	ORC4	VGNC	VGNC:32449

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