ORC5 - origin recognition complex subunit 5 Gene

Homo sapiens

Also known as ORC5L; ORC5P; ORC5T; PPP1R117

Gene ID: 5001 | Gene type: protein coding

About ORC5

Cytogenetic location: 7q22.1-q22.2 Genomic coordinates (GRCh38): 7:104,126,341-104,208,013 (from NCBI)

This gene has 8 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in testis (RPKM 5.7), prostate (RPKM 4.4) and 25 other tissues.

Summary

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010]

ORC5 Products(2)

mRNA	Protein	Name
NM_002553.4	NP_002544.1	origin recognition complex subunit 5 isoform 1
NM_181747.4	NP_859531.1	origin recognition complex subunit 5 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15232106	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA replication initiation	IDA IDA: Inferred from direct assay	16549788	GOA
involved in regulation of DNA replication	IDA IDA: Inferred from direct assay	31160578	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	31160578	GOA
part of nuclear origin of replication recognition complex	IDA IDA: Inferred from direct assay	20932478	GOA
part of nuclear origin of replication recognition complex	IPI IPI: Inferred from physical interaction	16549788	GOA
part of origin recognition complex	IDA IDA: Inferred from direct assay	17716973	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ORC5 Protein Structure

AAA_16

ORC5_C

0
100
200
300
400
435 a.a.

Protein Preferred Names

Protein Names

origin recognition complex subunit 5

protein phosphatase 1, regulatory subunit 117

ORC5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ORC5	O43913	ORC1	Homo sapiens	Q13415	Pull Down	17716973
Intra	ORC5	O43913	ORC4	Homo sapiens	O43929	Anti Bait CoIP	17716973
Intra	ORC5	O43913	ORC4	Homo sapiens	O43929	Protein Array	15232106
Intra	ORC5	O43913	ORC3	Homo sapiens	Q9UBD5	Anti Bait CoIP	17716973
Intra	ORC5	O43913	ORC2	Homo sapiens	Q13416	Anti Bait CoIP	17716973

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome	Ear, Patella, Short Stature Syndrome
Microtia, Absent Patellae, Micrognathia Syndrome	MGORS1
Eps	Ear-Patella-Short Stature Syndrome
Ear Patella Short Stature Syndrome	Microtia Absent Patellae Micrognathia Syndrome
Meier-Gorlin Syndrome, Type 1

Isolated Growth Hormone Deficiency, Type Ia

Ighd Ia	Primordial Dwarfism
Isolated Growth Hormone Deficiency Type Ia	Sexual Ateleiotic Dwarfism
Pituitary Dwarfism I	IGHD1A
Illig-Type Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, Type Ia
Congenital Ighd Type Ia	Congenital Isolated Gh Deficiency Type Ia
Congenital Isolated Growth Hormone Deficiency Type Ia	Pituitary Dwarfism 1
Growth Hormone Deficiency, Isolated, Autosomal Recessive	Autosomal Recessive Isolated Growth Hormone Deficiency
Isolated Growth Hormone Deficiency Type 1a	Congenital Ighd
Congenital Isolated Gh Deficiency	Congenital Isolated Growth Hormone Deficiency
Growth Hormone Deficiency, Isolated Autosomal Recessive	Illig Type Growth Hormone Deficiency
Non-Acquired Isolated Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, 1a
Growth Hormone Deficiency Isolated Autosomal Recessive	Dwarfism, Primordial
Dwarfism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09829	ORC5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ORC5	VGNC	VGNC:44144
Rattus norvegicus	ORC5	RGD	RGD:1561088
Mus musculus	ORC5	MGD	MGI:1347044
Felis catus	ORC5	VGNC	VGNC:68652
Bos taurus	ORC5	VGNC	VGNC:32450
Macaca mulatta	ORC5	VGNC	VGNC:75717

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