2. Gene
  3. LY96 - lymphocyte antigen 96 Gene

LY96 - lymphocyte antigen 96 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MD2; MD-2; ly-96; ESOP-1

Gene ID: 23643 | Gene type: protein coding

About LY96

Cytogenetic location: 8q21.11 Genomic coordinates (GRCh38): 8:73,991,392-74,099,857 (from NCBI)

This gene has 2 transcripts (splice variants) and 111 orthologues. Broad expression in spleen (RPKM 8.6), appendix (RPKM 8.4) and 22 other tissues.

Summary

This gene encodes a protein which associates with Toll-like Receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]

LY96 Products(2)

mRNA Protein Name
NM_001195797.2 NP_001182726.1 lymphocyte antigen 96 isoform 2 precursor
NM_015364.5 NP_056179.4 lymphocyte antigen 96 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables lipopolysaccharide immune receptor activity IDA
IDA: Inferred from direct assay
19252480 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15728506 GOA
Biological Process GO Annotation Evidence Reference Source
involved in detection of lipopolysaccharide IDA
IDA: Inferred from direct assay
19252480 GOA
acts upstream of or within response to lipopolysaccharide IDA
IDA: Inferred from direct assay
12594207 GOA
involved in response to lipopolysaccharide IDA
IDA: Inferred from direct assay
14607928 GOA
involved in toll-like receptor signaling pathway IDA
IDA: Inferred from direct assay
14607928 GOA
Cellular Component GO Annotation Evidence Reference Source
part of lipopolysaccharide receptor complex IDA
IDA: Inferred from direct assay
11274165 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
11274165 GOA
part of receptor complex IPI
IPI: Inferred from physical interaction
19252480 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LY96 Protein Structure

E1_DerP2_DerF2

E1_DerP2_DerF2: ML domain (31 - 152)

  • 0
  • 100
  • 160 a.a.
Protein Preferred Names Protein Names

lymphocyte antigen 96

myeloid differentiation protein-2

LY96 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
LY96 Q9Y6Y9 LCN2 Homo sapiens P80188
Y2H Prey Pooling
32296183
Intra
LY96 Q9Y6Y9 LCN2 Homo sapiens P80188
Y2H Array
32296183
Intra
LY96 Q9Y6Y9 TLR4 Homo sapiens O00206-1
GMS
19252480
Intra
LY96 Q9Y6Y9 TLR4 Homo sapiens O00206-1
Solid Phase Assay
22474354
Intra
LY96 Q9Y6Y9 TLR4 Homo sapiens O00206-1
X-Ray Diffraction
19252480
Intra
LY96 Q9Y6Y9 TLR4 Homo sapiens O00206
Anti Tag CoIP
15728506
Intra
LY96 Q9Y6Y9 TLR4 Homo sapiens O00206
Crosslink
17803912
Intra
LY96 Q9Y6Y9 TLR4 Homo sapiens O00206
GMS
17803912
Intra
LY96 Q9Y6Y9 MESD Homo sapiens Q14696
Y2H Prey Pooling
32296183
Intra
LY96 Q9Y6Y9 MESD Homo sapiens Q14696
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LY96 Proteins

Cat. No. Product Name Accession Purity
HY-P701067 MD2 Protein, Human (His) Q9Y6Y9-1 (Q19-N160) ≥95%

Related Diseases

Diseases Alias
Melioidosis

Melioidosis, Susceptibility To

Acute And Fulminating Melioidosis

Nightcliff Gardener'S Disease

Pseudoglanders

Subacute And Chronic Melioidosis

Burkholderia Pseudomallei Infection

Whitmore Disease

Whitmore'S Disease

B Pseudomallei Infection

Epizootic Lymphangitis

Infection Due To Burkholderia Pseudomallei

Infection Due To Burkholderia Pseudomallei Nos

Infection Due To Malleomyces Pseudomallei

Infection Due To Pseudomonas Pseudomallei

Infection Due To Pseudomonas Pseudomallei Nos

Infection Due To Whitmore Bacillus

Stanton Disease
Toxic Shock Syndrome

Septic Shock

Toxic Shock

Tss

Shock, Septic

Staphylococcal Toxic Shock Syndrome

Tss - [Toxic Shock Syndrome]
Thyrotoxic Exophthalmos
Endocrine Exophthalmos

Endocrine Exopthalmos

Thyroid Associated Opthalmopathies
Inflammatory Bowel Disease 20

IBD20
Acute Gonococcal Cervicitis

Gonococcal Cervicitis

Acute Gonorrhea Of Cervix
Bacterial Sepsis
Niemann-Pick Disease, Type C2

NPC2

Niemann-Pick Disease Type C2

Niemann-Pick C2 Disease

Niemann-Pick Disease C2
Wheat Allergy

Wheat Allergic Reaction

Wheat Hypersensitivity

Allergy To Wheat

Allergy Wheat
Acute Cervicitis
Disease By Infectious Agent

Infectious Disease

Infectious Diseases
Cataract 30

Cataract 30 Pulverulent

Cataract Coppock-Like

Ctrct30

Dusty Cataract

Cataract, Type 30
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07908 LY96 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LY96 MGD MGI:1341909
Rattus norvegicus LY96 RGD RGD:1302993
Bos taurus LY96 VGNC VGNC:53867
Canis familiaris LY96 VGNC VGNC:42878
Felis catus LY96 VGNC VGNC:63335
Macaca mulatta LY96 VGNC VGNC:74303
Macaca fascicularis LY96 NCBI NCBI:102118398
Others LY96 NCBI