TMEFF2 - transmembrane protein with EGF like and two follistatin like domains 2 Gene

Homo sapiens

Also known as TR; HPP1; TPEF; TR-2; TENB2; CT120.2

Gene ID: 23671 | Gene type: protein coding

About TMEFF2

Cytogenetic location: 2q32.3 Genomic coordinates (GRCh38): 2:191,949,046-192,194,933 (from NCBI)

This gene has 4 transcripts (splice variants), 202 orthologues and 27 paralogues. Biased expression in prostate (RPKM 5.9), brain (RPKM 4.8) and 3 other tissues.

Summary

This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate Cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple Cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

TMEFF2 Products(3)

mRNA	Protein	Name
NM_001305134.2	NP_001292063.1	tomoregulin-2 isoform 2 precursor
NM_001305145.1	NP_001292074.1	tomoregulin-2 isoform 3 precursor
NM_016192.4	NP_057276.2	tomoregulin-2 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	26402097	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of cell migration	IDA IDA: Inferred from direct assay	24632071	GOA
acts upstream of or within negative regulation of integrin biosynthetic process	IMP IMP: Inferred from mutant phenotype	24632071	GOA
acts upstream of or within negative regulation of stress fiber assembly	IDA IDA: Inferred from direct assay	24632071	GOA
acts upstream of or within wound healing, spreading of cells	IDA IDA: Inferred from direct assay	24632071	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEFF2 Protein Structure

Kazal_2

hEGF

0
100
200
300
374 a.a.

Protein Preferred Names

Protein Names

tomoregulin-2

cancer/testis antigen family 120, member 2

Recombinant TMEFF2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700470	TMEFF2/Tomoregulin-2 Protein, Human (HEK293, His)	Q9UIK5 (F41-V320)	≥95%

Related Diseases

Diseases

Alias

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14642	TMEFF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TMEFF2	RGD	RGD:1308839
Mus musculus	TMEFF2	MGD	MGI:1861735
Canis familiaris	TMEFF2	VGNC	VGNC:47442
Bos taurus	TMEFF2	VGNC	VGNC:35940
Macaca mulatta	TMEFF2	VGNC	VGNC:78569
Felis catus	TMEFF2	VGNC	VGNC:66252
Others	TMEFF2	NCBI

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