2. Gene
  3. TRHR - thyrotropin releasing hormone receptor Gene

TRHR - thyrotropin releasing hormone receptor Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CHNG7; TRH-R

Gene ID: 7201 | Gene type: protein coding

About TRHR

Cytogenetic location: 8q23.1 Genomic coordinates (GRCh38): 8:109,086,585-109,121,565 (from NCBI)

This gene has 2 transcripts (splice variants), 269 orthologues, 15 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011]

TRHR Products(1)

mRNA Protein Name
NM_003301.7 NP_003292.1 thyrotropin-releasing hormone receptor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRHR Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (42 - 320)

  • 0
  • 100
  • 200
  • 300
  • 398 a.a.
Protein Preferred Names Protein Names

thyrotropin-releasing hormone receptor

thyroliberin receptor

TRHR Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TRHR P34981 TMEFF2 Homo sapiens Q9UIK5
Validated Y2H
32296183
Intra
TRHR P34981 TMEM239 Homo sapiens Q8WW34-2
Validated Y2H
32296183
Intra
TRHR P34981 C1QL4 Homo sapiens Q86Z23
Validated Y2H
32296183
Intra
TRHR P34981 FAM241B Homo sapiens Q96D05-2
Validated Y2H
32296183
Intra
TRHR P34981 SLC41A1 Homo sapiens Q8IVJ1
Validated Y2H
32296183
Intra
TRHR P34981 SLC39A2 Homo sapiens Q9NP94
Validated Y2H
32296183
Intra
TRHR P34981 EFNA5 Homo sapiens P52803
Validated Y2H
32296183
Intra
TRHR P34981 SLC39A9 Homo sapiens Q9NUM3
Validated Y2H
32296183
Intra
TRHR P34981 ACP2 Homo sapiens P11117
Anti Tag CoIP
28514442
Intra
TRHR P34981 ACP2 Homo sapiens P11117
Anti Tag CoIP
33961781
Intra
TRHR P34981 IER3IP1 Homo sapiens Q9Y5U9
Validated Y2H
32296183
Intra
TRHR P34981 YIPF6 Homo sapiens Q96EC8
Validated Y2H
32296183
Intra
TRHR P34981 NIPAL4 Homo sapiens Q0D2K0
Validated Y2H
32296183
Intra
TRHR P34981 UBE2J1 Homo sapiens Q9Y385
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypothyroidism, Congenital, Nongoitrous, 7

CHNG7

Thyrotropin-Releasing Hormone Resistance, Generalized

Central Hypothyroidism Due To Trh Receptor Deficiency

Resistance To Thyrotropin-Releasing Hormone Syndrome

Trh Resistance Syndrome

Congenital Nongoitrous Hypothyroidism 7

Hypothyroidism, Congenital, Non-Goitrous, 7

Hypothyroidism, Congenital, Nongoitrous, Type 7
Hypothyroidism

Thyroid Diseases

Thyroid Disease

Thyroid Deficiency

Thyroid Insufficiency

Dysfunction Thyroid

Thyroid Dysfunction
Hypothyroidism, Central, With Testicular Enlargement

X-Linked Central Congenital Hypothyroidism With Late-Onset Testicular Enlargement

CHTE

Hypothyroidism, Central, And Testicular Enlargement

Igsf1 Deficiency Syndrome

X-Linked Central Congenital Hypothyroidism With Late-Onset Macroorchidism

Central Hypothyroidism And Testicular Enlargement

Hypothyroidism, Central, Testicular Enlargement
Acromegaly

Gigantism

Growth Hormone Excess

Pituitary Giant

Somatotroph Adenoma

Growth Hormone-Secreting Pituitary Adenoma
Congenital Hypothyroidism

Cretinism

Neonatal Hypothyroidism

Ch

Cht

Congenital Myxedema

Myxedema, Congenital

Endemic Cretinism

Congenital Iodine-Deficiency Syndrome

Fetal Iodine Deficiency Syndrome

Congenital Iodine-Deficiency Hypothyroidism Nos
Hyperthyroidism

Overactive Thyroid
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0596 Taltirelin 99.86% Unkown
HY-B0596A Taltirelin acetate 98.77% Unkown
Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0596S Taltirelin-13C,d3 / Unkown
HY-RS15013 TRHR Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TRHR VGNC VGNC:36306
Mus musculus TRHR MGD MGI:98824
Felis catus TRHR VGNC VGNC:66526
Rattus norvegicus TRHR RGD RGD:3904
Macaca mulatta TRHR VGNC VGNC:78645
Canis familiaris TRHR VGNC VGNC:47799