2. Gene
  3. PPIL2 - peptidylprolyl isomerase like 2 Gene

PPIL2 - peptidylprolyl isomerase like 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CYC4; CYP60; UBOX7; Cyp-60; hCyP-60

Gene ID: 23759 | Gene type: protein coding

About PPIL2

Cytogenetic location: 22q11.21-q11.22 Genomic coordinates (GRCh38): 22:21,666,012-21,700,015 (from NCBI)

This gene has 46 transcripts (splice variants), 202 orthologues and 22 paralogues. Ubiquitous expression in thyroid (RPKM 15.3), lymph node (RPKM 12.4) and 25 other tissues.

Summary

This gene is a member of the Cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and Infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]

PPIL2 Products(4)

mRNA Protein Name
NM_001317996.2 NP_001304925.1 RING-type E3 ubiquitin-protein ligase PPIL2 isoform a
NM_014337.4 NP_055152.1 RING-type E3 ubiquitin-protein ligase PPIL2 isoform a
NM_148175.3 NP_680480.1 RING-type E3 ubiquitin-protein ligase PPIL2 isoform a
NM_148176.3 NP_680481.1 RING-type E3 ubiquitin-protein ligase PPIL2 isoform b

PPIL2 Protein Structure

Rtf2

Rtf2: Rtf2 RING-finger (38 - 242)

Pro_isomerase

Pro_isomerase: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD (281 - 431)

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  • 520 a.a.
Protein Preferred Names Protein Names

RING-type E3 ubiquitin-protein ligase PPIL2

PPIase

Recombinant PPIL2 Proteins

Cat. No. Product Name Accession Purity
HY-P77151 PPIL2 Protein, Human (His) Q13356-2 (G280-P457) ≥95%

Related Diseases

Diseases Alias
Hawkinsinuria

4-Alpha-Hydroxyphenylpyruvate Hydroxylase Deficiency

4-Hppd Deficiency

4-Hydroxyphenylpyruvic Acid Dioxygenase Deficiency

HWKS

HAWK
Angiostrongyliasis

A. Cantonensis Angiostrongyliasis
Kidney Rhabdoid Cancer

Rhabdoid Tumor Of The Kidney

Kidney Rhabdoid Tumor

Renal Rhabdoid Tumor
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10955 PPIL2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PPIL2 RGD RGD:1309484
Canis familiaris PPIL2 VGNC VGNC:44856
Felis catus PPIL2 VGNC VGNC:68989
Macaca mulatta PPIL2 VGNC VGNC:76239
Bos taurus PPIL2 VGNC VGNC:33202
Mus musculus PPIL2 MGD MGI:2447857
Others PPIL2 NCBI