Map2k5 - mitogen-activated protein kinase kinase 5 Gene

Mus musculus

Also known as MEK5; Mapkk5; Prkmk5

Gene ID: 23938 | Gene type: protein coding

About Map2k5

Chromosome 9: 63,071,050-63,285,184 reverse strand.GRCm39:CM001002.3

This gene has 3 transcripts (splice variants), 209 orthologues, 8 paralogues and is associated with 11 phenotypes. Ubiquitous expression in adrenal adult (RPKM 1.5), thymus adult (RPKM 8.4) and 28 other tissues.

Summary

Predicted to enable ATP binding activity and MAP kinase kinase activity. Acts upstream of or within MAPK cascade and heart development. Located in spindle. Is expressed in early conceptus; oocyte; and telencephalon. Orthologous to human MAP2K5 (mitogen-activated protein kinase kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Map2k5 Products(4)

mRNA	Protein	Name
NM_001364493.1	NP_001351422.1	dual specificity mitogen-activated protein kinase kinase 5 isoform 3
NM_001364494.1	NP_001351423.1	dual specificity mitogen-activated protein kinase kinase 5 isoform 4
NM_001364492.1	NP_001351421.1	dual specificity mitogen-activated protein kinase kinase 5 isoform 2
NM_011840.3	NP_035970.1	dual specificity mitogen-activated protein kinase kinase 5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables MAP kinase kinase activity	IDA IDA: Inferred from direct assay	19654213	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12912994	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within MAPK cascade	IMP IMP: Inferred from mutant phenotype	15601854	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	15601854	MGI
involved in insulin-like growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	19654213	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in spindle	IDA IDA: Inferred from direct assay	15509711	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Map2k5 Protein Structure

PB1_Map2k5

PKc_MKK5

0
100
200
300
400
448 a.a.

Protein Preferred Names

Protein Names

dual specificity mitogen-activated protein kinase kinase 5

MAP kinase kinase 5

MAPK/ERK kinase 5

Map2k5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Map2k5	Q9WVS7	Map3k2	Mus musculus	Q61083	Pull Down	12912994
Intra	Map2k5	Q9WVS7	Map3k2	Mus musculus	Q61083	CoIP	12912994
Intra	Map2k5	Q9WVS7	Map3k3	Mus musculus	Q61084	CoIP	12912994
Intra	Map2k5	Q9WVS7	Map3k3	Mus musculus	Q61084	Y2H	15102471
Intra	Map2k5	Q9WVS7	Map3k3	Mus musculus	Q61084	Pull Down	12912994
Intra	Map2k5	Q9WVS7	Sqstm1	Mus musculus	Q64337	Y2H	15102471
Intra	Map2k5	Q9WVS7	Nap1l1	Mus musculus	P28656	Y2H	15102471

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS08041	MAP2K5 Human Pre-designed siRNA Set A	/	Unkown
HY-RS08042	Map2k5 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS08043	Map2k5 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map2k5	NCBI	NCBI:5607

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