2. Gene
  3. Tiam2 - T cell lymphoma invasion and metastasis 2 Gene

Tiam2 - T cell lymphoma invasion and metastasis 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as STEF; mKIAA2016; 3000002F19Rik

Gene ID: 24001 | Gene type: protein coding

About Tiam2

Summary

Enables GTPase activator activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in activation of GTPase activity; positive regulation of axonogenesis; and small GTPase mediated signal transduction. Located in cytoplasm and membrane. Is expressed in several structures, including cartilage; central nervous system; genitourinary system; liver; and respiratory system. Orthologous to human TIAM2 (TIAM Rac1 associated GEF 2). [provided by Alliance of Genome Resources, Apr 2022]

Tiam2 Products(4)

mRNA Protein Name
NM_001122998.1 NP_001116470.1 rho guanine nucleotide exchange factor TIAM2 isoform 1
NM_001286757.1 NP_001273686.1 rho guanine nucleotide exchange factor TIAM2 isoform 2
NM_001286758.1 NP_001273687.1 rho guanine nucleotide exchange factor TIAM2 isoform 3
NM_011878.2 NP_036008.2 rho guanine nucleotide exchange factor TIAM2 isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
11707441 MGI
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
10364228 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10364228 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11707441 MGI
located in membrane IDA
IDA: Inferred from direct assay
11707441 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rho guanine nucleotide exchange factor TIAM2

T-lymphoma invasion and metastasis-inducing protein 2

RAS-related C3 botulinum substrate 1, guanine nucleotide exchange factor 1

SIF and TIAM1-like exchange factor

T-cell lymphoma invasion and metastasis 2

RAS-related C3 botulinum substrate 1, guanine nucleotide exchange factor 1

TIAM-2

Tiam2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Tiam2 Q6ZPF3 Cd44 Mus musculus P15379
SPR
19893486
Cross
Tiam2 Q6ZPF3 PARD3 Homo sapiens Q8TEW0-2
SPR
19893486
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14516 TIAM2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tiam2 NCBI NCBI:26230