Mrap2 - melanocortin 2 receptor accessory protein 2 Gene

Mus musculus

Gene ID: 244958 | Gene type: protein coding

About Mrap2

Summary

Enables signaling receptor regulator activity and type 4 Melanocortin Receptor binding activity. Involved in energy homeostasis; energy reserve metabolic process; and feeding behavior. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum and plasma membrane. Human ortholog(s) of this gene implicated in obesity. Orthologous to human MRAP2 (melanocortin 2 receptor accessory protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Mrap2 Products(3)

mRNA	Protein	Name
NM_001101482.2	NP_001094952.2	melanocortin-2 receptor accessory protein 2
NM_001177731.1	NP_001171202.1	melanocortin-2 receptor accessory protein 2
NM_001359955.1	NP_001346884.1	melanocortin-2 receptor accessory protein 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	35311242	MGI
enables signaling receptor regulator activity	IMP IMP: Inferred from mutant phenotype	23869016	MGI
enables type 4 melanocortin receptor binding	IDA IDA: Inferred from direct assay	23869016	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in energy homeostasis	IMP IMP: Inferred from mutant phenotype	23869016	MGI
involved in energy reserve metabolic process	IMP IMP: Inferred from mutant phenotype	23869016	MGI
involved in feeding behavior	IMP IMP: Inferred from mutant phenotype	23869016	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

melanocortin-2 receptor accessory protein 2

Mrap2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Mrap2	D3Z1Q2	Mchr1	Mus musculus	Q8JZL2	BiFC	35311242

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08639	MRAP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mrap2	NCBI	NCBI:112609

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