Mchr1 - melanin-concentrating hormone receptor 1 Gene

Mus musculus

Also known as Gpr24; Mch1r

Gene ID: 207911 | Gene type: protein coding

About Mchr1

Chromosome 15: 81,119,700-81,123,165 forward strand.GRCm39:CM001008.3

This gene has 1 transcript (splice variant), 241 orthologues, 55 paralogues and is associated with 35 phenotypes. Broad expression in cortex adult (RPKM 5.3), frontal lobe adult (RPKM 4.6) and 19 other tissues.

Summary

Enables signaling receptor binding activity. Predicted to be involved in several processes, including neuropeptide signaling pathway; positive regulation of calcium ion transport; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in ciliary membrane and non-motile cilium. Is expressed in brain and lung. Human ortholog(s) of this gene implicated in morbid obesity. Orthologous to human MCHR1 (melanin concentrating hormone receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Mchr1 Products(1)

mRNA	Protein	Name
NM_145132.2	NP_660114.1	melanin-concentrating hormone receptor 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	35311242	MGI
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	23029470	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in ciliary membrane	IDA IDA: Inferred from direct assay	22139371	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	23029470	MGI
located in non-motile cilium	IDA IDA: Inferred from direct assay	18334641	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15950311	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mchr1 Protein Structure

7tmA_MCHR1

0
100
200
300
353 a.a.

Protein Preferred Names

Protein Names

melanin-concentrating hormone receptor 1

G protein coupled receptor 24	Gpr24-9 protein coupled receptor
MCH receptor 1	MCHR
SLC-1	somatostatin receptor-like protein

Mchr1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Mchr1	Q8JZL2	Mrap2	Mus musculus	D3Z1Q2	Anti Tag CoIP	35311242
Intra	Mchr1	Q8JZL2	Mrap2	Mus musculus	D3Z1Q2	Confocal	35311242

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-U00257	AZD1979	Antagonist	98.09%	Phase 1

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107625A	SNAP 94847 hydrochloride	Inhibitor	99.90%	Unkown
HY-100321	MCHR1 antagonist 2		98.27%	Unkown
HY-P1204	[Ala17]-MCH	Agonist	98.28%	Unkown
HY-12433	BMS-819881		/	Unkown
HY-100318	NGD-4715	Antagonist	/	Unkown
HY-101699	AMG-076 free base	Antagonist	/	Unkown
HY-107625	SNAP 94847	Antagonist	/	Unkown
HY-107626A	ATC0065 free base	Antagonist	/	Unkown
HY-116031	ATC0175 free base	Antagonist	/	Unkown
HY-120608	BMS-814580	Inhibitor	/	Unkown
HY-136152	MCHR1 antagonist 3	Antagonist	/	Unkown
HY-161899	MCHR1 antagonist 4	Antagonist	/	Unkown
HY-P1204A	[Ala17]-MCH TFA	Agonist	/	Unkown
HY-RS08225	MCHR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08226	Mchr1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08227	Mchr1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-101699A	AMG-076	Antagonist	/	Unkown
HY-107626	ATC0065	Antagonist	/	Unkown
HY-U00353	MCHR1 antagonist 1	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mchr1	NCBI	NCBI:2847

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