2. Gene
  3. Il5 - interleukin 5 Gene

Il5 - interleukin 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 24497 | Gene type: protein coding

About Il5

Primary_assembly 10: 37,874,342-37,877,213 forward strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 91 orthologues and is associated with 51 phenotypes. Low expression observed in reference dataset.

Summary

Enables cytokine activity and interleukin-5 receptor binding activity. Involved in several processes, including positive regulation of B cell proliferation; positive regulation of eosinophil differentiation; and positive regulation of receptor signaling pathway via JAK-STAT. Located in extracellular space. Used to study asthma. Biomarker of several diseases, including allergic rhinitis; esophageal cancer; middle cerebral artery infarction; peptic esophagitis; and prostatic hypertrophy. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL5 (interleukin 5). [provided by Alliance of Genome Resources, Apr 2022]

Il5 Products(1)

mRNA Protein Name
NM_021834.1 NP_068606.1 interleukin-5 precursor

Il5 Protein Structure

IL5

IL5: pfam02025 (19 - 130)

  • 0
  • 100
  • 132 a.a.
Protein Preferred Names Protein Names

interleukin-5

B-cell growth factor II

BCGF-II

IL-5

Interleukin 5 (colony-stimulating factor, eosinophil)

T-cell replacing factor

TRF

cytotoxic T-lymphocyte inducer

eosinophil differentiation factor

Recombinant Il5 Proteins

Cat. No. Product Name Accession Purity
HY-P7102 IL-5 Protein, Rat Q08125 (M20-V132) ≥95%
HY-P7102A IL-5 Protein, Rat (CHO) Q08125 (M20-V132) ≥95%

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17002 Suplatast (Tosilate) Inhibitor 98.33% Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9945 Mepolizumab 98.00% Unkown
HY-P9923 Benralizumab 99.1% Unkown
HY-P9949 Reslizumab Antagonist 99.40% Unkown
Clinical Phase
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P9945A Mepolizumab (anti-IL5) 97.50% Phase 4
HY-P99371 Lirentelimab Inducer 99.91% Phase 3
Pre-clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19969 YM-90709 Inhibitor 99.77% Unkown
HY-147660 IMMH001 Agonist 98.10% Unkown
HY-N8309 Luteolin-4'-O-glucoside Inhibitor 99.05% Unkown
HY-110295 SPL-334 Inhibitor / Unkown
HY-165484 AVP-13358 Inhibitor / Unkown
HY-19472 RWJ-58643 / Unkown
HY-19486 UR-1505 Inhibitor / Unkown
HY-P1111 Lyn peptide inhibitor Inhibitor / Unkown
HY-P1111A Lyn peptide inhibitor TFA Inhibitor / Unkown
HY-RS06770 IL5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06771 Il5 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06772 Il5 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06773 IL5RA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9923A Benralizumab (anti-IL5RA ) 99.60% Unkown
HY-P990058 Varokibart Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il5 NCBI NCBI:3567
Mus musculus Il5 NCBI NCBI:16191
Susscrofa domestica Il5 NCBI
Leporidae Il5 NCBI