2. Gene
  3. Il5 - interleukin 5 Gene

Il5 - interleukin 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Il-5

Gene ID: 16191 | Gene type: protein coding

About Il5

Chromosome 11: 53,611,621-53,615,933 forward strand.GRCm39:CM001004.3

This gene has 1 transcript (splice variant), 91 orthologues and is associated with 22 phenotypes. Low expression observed in reference dataset.

Summary

Enables cytokine activity. Involved in positive regulation of DNA-binding transcription factor activity; positive regulation of immunoglobulin production; and positive regulation of transcription, DNA-templated. Acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation. Located in extracellular space. Is expressed in colon; thymus; and thymus primordium. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL5 (interleukin 5). [provided by Alliance of Genome Resources, Apr 2022]

Il5 Products(1)

mRNA Protein Name
NM_010558.1 NP_034688.1 interleukin-5 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cytokine activity IDA
IDA: Inferred from direct assay
10872802 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
10872802 MGI
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
7749983 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
7749983 MGI
involved in positive regulation of immunoglobulin production IGI
IGI: Inferred from genetic interaction
18268038 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
10872802 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
11057672 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il5 Protein Structure

IL5

IL5: pfam02025 (20 - 131)

  • 0
  • 100
  • 133 a.a.
Protein Preferred Names Protein Names

interleukin-5

B-cell growth factor II

BCGF-II

T-cell replacing factor

TRF

cytotoxic T-lymphocyte inducer

eosinophil differentiation factor

Recombinant Il5 Proteins

Cat. No. Product Name Accession Purity
HY-P7081 IL-5 Protein, Mouse P04401 (M21-G133) ≥95%
HY-P7081A IL-5 Protein, Mouse (CHO) P04401 (M21-G133) ≥95%
HY-P70746 IL-5 Protein, Mouse (HEK293, His) P04401 (M21-G133) ≥95%
HY-P73219 IL-5 Protein, Mouse (sf9, His) P04401 (M21-G133) ≥95%
HY-P78155 IL-5 Protein, Mouse (Biotinylated, HEK293, His-Avi) P04401 (M21-G133) ≥95%
HY-P78314 IL-5 Protein, Mouse (HEK293, His-Avi) P04401 (M21-G133) ≥95%
HY-P700215AF Animal-Free IL-5 Protein, Mouse (His) P04401 (M21-G133) ≥95%

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17002 Suplatast (Tosilate) Inhibitor 98.33% Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9945 Mepolizumab 98.00% Unkown
HY-P9949 Reslizumab Antagonist 99.40% Unkown
HY-P9923 Benralizumab 99.1% Unkown
Clinical Phase
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P9945A Mepolizumab (anti-IL5) 95.00% Phase 4
HY-P99371 Lirentelimab Inducer 99.91% Phase 3
Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19969 YM-90709 Inhibitor 99.77% Unkown
HY-147660 IMMH001 Agonist 98.10% Unkown
HY-N8309 Luteolin-4'-O-glucoside Inhibitor 99.05% Unkown
HY-110295 SPL-334 Inhibitor / Unkown
HY-165484 AVP-13358 Inhibitor / Unkown
HY-19472 RWJ-58643 / Unkown
HY-P1111 Lyn peptide inhibitor Inhibitor / Unkown
HY-P1111A Lyn peptide inhibitor TFA Inhibitor / Unkown
HY-RS06770 IL5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06771 Il5 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06772 Il5 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06773 IL5RA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9923A Benralizumab (anti-IL5RA ) 99.60% Unkown
HY-P990058 Varokibart Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il5 NCBI NCBI:3567
Susscrofa domestica Il5 NCBI
Leporidae Il5 NCBI
Rattus norvegicus Il5 NCBI NCBI:24497