2. Gene
  3. Cxcl10 - C-X-C motif chemokine ligand 10 Gene

Cxcl10 - C-X-C motif chemokine ligand 10 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as IP-10; Scyb10

Gene ID: 245920 | Gene type: protein coding

About Cxcl10

Summary

Enables chemokine activity. Involved in several processes, including response to auditory stimulus; response to gamma radiation; and response to vitamin D. Located in extracellular space. Used to study adult respiratory distress syndrome; myocarditis; proteinuria; renovascular hypertension; and type 1 diabetes mellitus. Biomarker of brain ischemia; encephalitis; and uveitis. Human ortholog(s) of this gene implicated in hepatitis B and middle cerebral artery infarction. Orthologous to human CXCL10 (C-X-C motif chemokine ligand 10). [provided by Alliance of Genome Resources, Apr 2022]

Cxcl10 Products(1)

mRNA Protein Name
NM_139089.2 NP_620789.2 C-X-C motif chemokine 10 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chemokine activity IDA
IDA: Inferred from direct assay
9288136 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to heat IEP
IEP: Inferred from expression pattern
17457469 RGD
involved in immune response IDA
IDA: Inferred from direct assay
12023393 RGD
involved in negative regulation of angiogenesis IDA
IDA: Inferred from direct assay
9288136 RGD
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
8798675 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
8798675 RGD
involved in positive regulation of leukocyte chemotaxis IDA
IDA: Inferred from direct assay
9288136 RGD
involved in response to auditory stimulus IEP
IEP: Inferred from expression pattern
15519684 RGD
involved in response to gamma radiation IEP
IEP: Inferred from expression pattern
19084914 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
9288136 RGD
involved in response to vitamin D IEP
IEP: Inferred from expression pattern
15637289 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
17457469 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

C-X-C motif chemokine 10

10 kDa interferon gamma-induced protein

chemokine (C-X-C motif) ligand 10

gamma-IP10

interferon-inducible cytokine IP-10

interferon-inducible protein 10

protein Mob-1

small inducible cytokine B subfamily (Cys-X-Cys) member 10

small inducible cytoki

Recombinant Cxcl10 Proteins

Cat. No. Product Name Accession Purity
HY-P7225 IP-10/CXCL10 Protein, Rat (HEK293) P48973 (I22-P98) ≥95%
HY-P74797 IP-10/CXCL10 Protein, Rat (P.pastoris, His) P48973/NP_620789 (I22-P98) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99190 Eldelumab Inhibitor 95.00% Phase 2
Pre-clinical Phase
Bioactive Molecules (19)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15319 AMG 487 Inhibitor 99.65% Unkown
HY-15589 GW9508 99.33% Unkown
HY-152237 TBK1-IN-1 Inhibitor 99.91% Unkown
HY-15320 NBI-74330 Antagonist 98.57% Unkown
HY-111149A PS372424 hydrochloride Agonist ≥98.0% Unkown
HY-152956 STING agonist-23 Agonist 99.16% Unkown
HY-124151 Adenosine-2'-monophosphate Activator 99.91% Unkown
HY-122891 SB02024 99.7% Unkown
HY-152959 STING agonist-26 Agonist 99.56% Unkown
HY-111149 PS372424 Agonist / Unkown
HY-RS03384 CXCL10 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-152957 STING agonist-24 Agonist / Unkown
HY-152958 STING agonist-25 Agonist / Unkown
HY-152961 STING agonist-28 Agonist / Unkown
HY-15319A (±)-AMG 487 Inhibitor / Unkown
HY-162675 COB-187 Inhibitor / Unkown
HY-W104821 Rosolic acid Activator / Unkown
HY-113730 VUF5834 / Unkown
HY-167884 PF-1367550 Inhibitor / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990639 NI-0801 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cxcl10 NCBI NCBI:3627
Mus musculus Cxcl10 NCBI NCBI:15945
Susscrofa domestica Cxcl10 NCBI
Macaca mulatta Cxcl10 NCBI NCBI:574243