CDC26 - cell division cycle 26 Gene

Homo sapiens

Also known as APC12; ANAPC12; C9orf17

Gene ID: 246184 | Gene type: protein coding

About CDC26

Cytogenetic location: 9q32 Genomic coordinates (GRCh38): 9:113,266,992-113,275,572 (from NCBI)

This gene has 2 transcripts (splice variants) and 176 orthologues. Ubiquitous expression in kidney (RPKM 9.9), appendix (RPKM 9.9) and 25 other tissues.

Summary

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein Ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008]

CDC26 Products(1)

mRNA	Protein	Name
NM_139286.4	NP_644815.1	anaphase-promoting complex subunit CDC26

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19668213	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in anaphase-promoting complex-dependent catabolic process	IDA IDA: Inferred from direct assay	29033132	GOA
involved in protein K11-linked ubiquitination	IDA IDA: Inferred from direct assay	18485873	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	29033132	GOA
involved in protein branched polyubiquitination	IDA IDA: Inferred from direct assay	29033132	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of anaphase-promoting complex	IDA IDA: Inferred from direct assay	10922056	GOA
part of anaphase-promoting complex	IPI IPI: Inferred from physical interaction	27120157	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC26 Protein Structure

ANAPC_CDC26

0
85 a.a.

Protein Preferred Names

Protein Names

anaphase-promoting complex subunit CDC26

CDC26 subunit of anaphase promoting complex

CDC26 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CDC26	Q8NHZ8	CDC16	Homo sapiens	Q13042-1	GMS	19668213
Intra	CDC26	Q8NHZ8	CDC16	Homo sapiens	Q13042-1	CD	19668213
Intra	CDC26	Q8NHZ8	CDC16	Homo sapiens	Q13042-1	X-Ray Diffraction	19668213
Intra	CDC26	Q8NHZ8	CDC16	Homo sapiens	Q13042-1	Pull Down	19668213
Intra	CDC26	Q8NHZ8	CDC16	Homo sapiens	Q13042	TAP	20360068
Intra	CDC26	Q8NHZ8	CDC16	Homo sapiens	Q13042	Y2H Array	25416956
Intra	CDC26	Q8NHZ8	CDC16	Homo sapiens	Q13042	Y2H Array	32296183
Intra	CDC26	Q8NHZ8	CDC16	Homo sapiens	Q13042	Anti Tag CoIP	33961781
Intra	CDC26	Q8NHZ8	CDC16	Homo sapiens	Q13042	Validated Y2H	25416956
Intra	CDC26	Q8NHZ8	CDC16	Homo sapiens	Q13042	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 27

RP27	Retinal Degeneration, Autosomal Recessive, Clumped Pigment Type
Retinal Degeneration Autosomal Recessive Clumped Pigment Type	RDCP
Clumped Pigmentary Retinal Degeneration	Retinitis Pigmentosa, Type 27

Cornea Cancer

Malignant Neoplasm Of Cornea	Neoplasm Of Cornea
Corneal Tumor	Malignant Corneal Tumor
Malignant Tumor Of Cornea	Primary Malignant Neoplasm Of Cornea

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02294	CDC26 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CDC26	VGNC	VGNC:38992
Bos taurus	CDC26	VGNC	VGNC:27065
Felis catus	CDC26	VGNC	VGNC:60652
Mus musculus	CDC26	MGD	MGI:1913690
Macaca mulatta	CDC26	VGNC	VGNC:70817
Rattus norvegicus	CDC26	RGD	RGD:1311342

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