2. Gene
  3. CDC16 - cell division cycle 16 Gene

CDC16 - cell division cycle 16 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as APC6; CUT9; ANAPC6; CDC16Hs

Gene ID: 8881 | Gene type: protein coding

About CDC16

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:114,234,897-114,272,723 (from NCBI)

This gene has 12 transcripts (splice variants), 211 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 27.4), thyroid (RPKM 21.1) and 25 other tissues.

Summary

The protein encoded by this gene functions as a protein ubiquitin Ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S Proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jan 2016]

CDC16 Products(7)

mRNA Protein Name
NM_001078645.3 NP_001072113.1 cell division cycle protein 16 homolog isoform 1
NM_001318517.3 NP_001305446.1 cell division cycle protein 16 homolog isoform 2
NM_001318518.3 NP_001305447.1 cell division cycle protein 16 homolog isoform 3
NM_001330101.2 NP_001317030.1 cell division cycle protein 16 homolog isoform 2
NM_001330104.2 NP_001317033.1 cell division cycle protein 16 homolog isoform 4
NM_001330105.2 NP_001317034.1 cell division cycle protein 16 homolog isoform 4
NM_003903.5 NP_003894.3 cell division cycle protein 16 homolog isoform 1

CDC16 Protein Structure

ANAPC3

ANAPC3: Anaphase-promoting complex, cyclosome, subunit 3 (15 - 94)

TPR_8

TPR_8: Tetratricopeptide repeat (132 - 160)

TPR_11

TPR_11: TPR repeat (448 - 508)

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  • 620 a.a.
Protein Preferred Names Protein Names

cell division cycle protein 16 homolog

anaphase-promoting complex, subunit 6

Related Diseases

Diseases Alias
Deafness, Autosomal Dominant 65

DFNA65

Autosomal Dominant Nonsyndromic Deafness 65

Autosomal Dominant Deafness 65

Deafness, Autosomal Dominant, 65

Deafness, Autosomal Dominant, Type 65
Deafness, Autosomal Recessive 86

DFNB86

Autosomal Recessive Nonsyndromic Deafness 86

Autosomal Recessive Deafness 86

Deafness, Autosomal Recessive, 86

Deafness, Nonsyndromic, Autosomal Recessive, Type 86
Developmental And Epileptic Encephalopathy 16

DEE16

Epileptic Encephalopathy, Early Infantile, 16

Eiee16

Developmental And Epileptic Encephalopathy, 16

Early Infantile Epileptic Encephalopathy 16

Progressive Myoclonic Epilepsy With Dystonia

Pmed

Progressive Myoclonus Epilepsy With Dystonia

Encephalopathy, Epileptic, Early Infantile, Type 16
Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation, And Seizures Syndrome

Door Syndrome

Doors Syndrome

Digitorenocerebral Syndrome

Autosomal Recessive Deafness-Onychodystrophy Syndrome

Deafness-Onychoosteodystrophy-Intellectual Disability Syndrome

DOORS

Drc Syndrome

Eronen Syndrome

Deafness-Onychodystrophy-Osteodystrophy-Intellectual Disability Syndrome

Brachydactyly Due To Absence Of Distal Phalanges

Deafness-Onychodystrophy-Osteodystrophy-Intellectual Disability-Seizures Syndrome

Deafness, Onychodystrophy, Osteodystrophy, And Mental Retardation Syndrome

Deafness-Oncychodystrophy-Osteodystrophy-Intellectual Disability Syndrome

Autosomal Recessive Hearing Loss-Onychodystrophy Syndrome

Hearing Loss-Onychodystrophy-Osteodystrophy-Intellectual Disability Syndrome

Hearing Loss-Onychodystrophy-Osteodystrophy-Intellectual Disability-Seizures Syndrome

Hearing Loss-Onychoosteodystrophy-Intellectual Disability Syndrome

Deafness, Onychodystrophy, Osteodystrophy, Intellectual Disability, And Seizures Syndrome

Deafness, Congenital Onychodystrophy, Recessive Form

Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation Syndrome
Epilepsy, Rolandic, With Paroxysmal Exercise-Induced Dystonia And Writer'S Cramp

Rolandic Epilepsy-Paroxysmal Exercise-Induced Dystonia-Writer'S Cramp Syndrome

EPRPDC

Re-Ped-Wc

Epilepsy, Rolandic, With Proxysmal Exercise-Induce Dystonia And Writer'S Cramp

Epilepsy, Rolandic, With Paroxysmal Exercise-Induce Dystonia And Writer'S Cramp

Rolandic Epilepsy With Paroxysmal Exercise-Induced Dystonia And Writer'S Cramp

Rolandic-Type Focal Motor Epilepsy And Exercise-Induced Dystonia

Rolandic Epilepsy Exercise-Induced Dystonia

Epilepsy, Rolandic With Paroxysmal Exercise-Induced Dystonia And Writer'S Cramp
Martsolf Syndrome 1

Martsolf Syndrome

Cataract-Intellectual Disability-Hypogonadism Syndrome

MARTS1

Marts

Cataract-Mental Retardation-Hypogonadism

Martsolf
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02287 CDC16 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CDC16 VGNC VGNC:70792
Rattus norvegicus CDC16 RGD RGD:1305076
Canis familiaris CDC16 VGNC VGNC:54931
Bos taurus CDC16 VGNC VGNC:50037
Mus musculus CDC16 MGD MGI:1917207
Felis catus CDC16 VGNC VGNC:60648