CDC16 - cell division cycle 16 Gene

Homo sapiens

Also known as APC6; CUT9; ANAPC6; CDC16Hs

Gene ID: 8881 | Gene type: protein coding

About CDC16

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:114,234,897-114,272,723 (from NCBI)

This gene has 12 transcripts (splice variants), 211 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 27.4), thyroid (RPKM 21.1) and 25 other tissues.

Summary

The protein encoded by this gene functions as a protein ubiquitin Ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S Proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and Other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jan 2016]

CDC16 Products(7)

mRNA	Protein	Name
NM_001078645.3	NP_001072113.1	cell division cycle protein 16 homolog isoform 1
NM_001318517.3	NP_001305446.1	cell division cycle protein 16 homolog isoform 2
NM_001318518.3	NP_001305447.1	cell division cycle protein 16 homolog isoform 3
NM_001330101.2	NP_001317030.1	cell division cycle protein 16 homolog isoform 2
NM_001330104.2	NP_001317033.1	cell division cycle protein 16 homolog isoform 4
NM_001330105.2	NP_001317034.1	cell division cycle protein 16 homolog isoform 4
NM_003903.5	NP_003894.3	cell division cycle protein 16 homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19668213	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in anaphase-promoting complex-dependent catabolic process	IDA IDA: Inferred from direct assay	29033132	GOA
involved in protein K11-linked ubiquitination	IDA IDA: Inferred from direct assay	18485873	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	29033132	GOA
involved in protein branched polyubiquitination	IDA IDA: Inferred from direct assay	29033132	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of anaphase-promoting complex	IDA IDA: Inferred from direct assay	16364912	GOA
part of anaphase-promoting complex	IPI IPI: Inferred from physical interaction	27120157	GOA
located in centrosome	IDA IDA: Inferred from direct assay	7736578	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	7736578	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC16 Protein Structure

ANAPC3

TPR_8

TPR_11

0
100
200
300
400
500
620 a.a.

Protein Preferred Names

Protein Names

cell division cycle protein 16 homolog

anaphase-promoting complex, subunit 6

CDC16 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CDC16	Q13042	CDC26	Homo sapiens	Q8NHZ8	Anti Tag CoIP	26496610
Intra	CDC16	Q13042	CDC26	Homo sapiens	Q8NHZ8	Y2H Array	31515488
Intra	CDC16	Q13042	CDC26	Homo sapiens	Q8NHZ8	Y2H Prey Pooling	25416956
Intra	CDC16	Q13042	CDC26	Homo sapiens	Q8NHZ8	Validated Y2H	32296183
Intra	CDC16	Q13042	CDC26	Homo sapiens	Q8NHZ8	TAP	20360068
Intra	CDC16	Q13042	CDC26	Homo sapiens	Q8NHZ8	Anti Tag CoIP	33961781
Intra	CDC16	Q13042	CDC26	Homo sapiens	Q8NHZ8	Anti Tag CoIP	35271311
Intra	CDC16	Q13042	CDC26	Homo sapiens	Q8NHZ8	Y2H	21988832
Intra	CDC16	Q13042	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	CDC16	Q13042	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	CDC16	Q13042	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Deafness, Autosomal Dominant 65

DFNA65	Autosomal Dominant Nonsyndromic Deafness 65
Autosomal Dominant Deafness 65	Deafness, Autosomal Dominant, 65
Deafness, Autosomal Dominant, Type 65

Deafness, Autosomal Recessive 86

DFNB86	Autosomal Recessive Nonsyndromic Deafness 86
Autosomal Recessive Deafness 86	Deafness, Autosomal Recessive, 86
Deafness, Nonsyndromic, Autosomal Recessive, Type 86

Developmental And Epileptic Encephalopathy 16

DEE16	Epileptic Encephalopathy, Early Infantile, 16
Eiee16	Developmental And Epileptic Encephalopathy, 16
Early Infantile Epileptic Encephalopathy 16	Progressive Myoclonic Epilepsy With Dystonia
Pmed	Progressive Myoclonus Epilepsy With Dystonia
Encephalopathy, Epileptic, Early Infantile, Type 16

Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation, And Seizures Syndrome

Door Syndrome	Doors Syndrome
Digitorenocerebral Syndrome	Autosomal Recessive Deafness-Onychodystrophy Syndrome
Deafness-Onychoosteodystrophy-Intellectual Disability Syndrome	DOORS
Drc Syndrome	Eronen Syndrome
Deafness-Onychodystrophy-Osteodystrophy-Intellectual Disability Syndrome	Brachydactyly Due To Absence Of Distal Phalanges
Deafness-Onychodystrophy-Osteodystrophy-Intellectual Disability-Seizures Syndrome	Deafness, Onychodystrophy, Osteodystrophy, And Mental Retardation Syndrome
Deafness-Oncychodystrophy-Osteodystrophy-Intellectual Disability Syndrome	Autosomal Recessive Hearing Loss-Onychodystrophy Syndrome
Hearing Loss-Onychodystrophy-Osteodystrophy-Intellectual Disability Syndrome	Hearing Loss-Onychodystrophy-Osteodystrophy-Intellectual Disability-Seizures Syndrome
Hearing Loss-Onychoosteodystrophy-Intellectual Disability Syndrome	Deafness, Onychodystrophy, Osteodystrophy, Intellectual Disability, And Seizures Syndrome
Deafness, Congenital Onychodystrophy, Recessive Form	Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation Syndrome

Epilepsy, Rolandic, With Paroxysmal Exercise-Induced Dystonia And Writer'S Cramp

Rolandic Epilepsy-Paroxysmal Exercise-Induced Dystonia-Writer'S Cramp Syndrome	EPRPDC
Re-Ped-Wc	Epilepsy, Rolandic, With Proxysmal Exercise-Induce Dystonia And Writer'S Cramp
Epilepsy, Rolandic, With Paroxysmal Exercise-Induce Dystonia And Writer'S Cramp	Rolandic Epilepsy With Paroxysmal Exercise-Induced Dystonia And Writer'S Cramp
Rolandic-Type Focal Motor Epilepsy And Exercise-Induced Dystonia	Rolandic Epilepsy Exercise-Induced Dystonia
Epilepsy, Rolandic With Paroxysmal Exercise-Induced Dystonia And Writer'S Cramp

Martsolf Syndrome 1

Martsolf Syndrome	Cataract-Intellectual Disability-Hypogonadism Syndrome
MARTS1	Marts
Cataract-Mental Retardation-Hypogonadism	Martsolf

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02287	CDC16 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CDC16	VGNC	VGNC:70792
Rattus norvegicus	CDC16	RGD	RGD:1305076
Canis familiaris	CDC16	VGNC	VGNC:54931
Bos taurus	CDC16	VGNC	VGNC:50037
Mus musculus	CDC16	MGD	MGI:1917207
Felis catus	CDC16	VGNC	VGNC:60648

Name
Email *

	Sorry, but the email address you supplied was invalid.