Ppp3ca - protein phosphatase 3 catalytic subunit alpha Gene

Rattus norvegicus

Also known as Calna1

Gene ID: 24674 | Gene type: protein coding

About Ppp3ca

Summary

Enables Calmodulin binding activity and calmodulin-dependent protein Phosphatase activity. Involved in several processes, including cellular response to glucose stimulus; negative regulation of Insulin secretion; and response to amphetamine. Located in cytosol. Part of Calcineurin complex. Is active in synapse. Colocalizes with slit diaphragm. Biomarker of kidney disease. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 91. Orthologous to human PPP3CA (protein Phosphatase 3 catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Ppp3ca Products(1)

mRNA	Protein	Name
NM_017041.2	NP_058737.1	protein phosphatase 3 catalytic subunit alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium-dependent protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	12135494	RGD
enables calmodulin binding	IDA IDA: Inferred from direct assay	12135494	RGD
enables calmodulin-dependent protein phosphatase activity	IDA IDA: Inferred from direct assay	24018048	RGD
enables phosphoprotein phosphatase activity	IDA IDA: Inferred from direct assay	1322410	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10593895	RGD
enables protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	12135494	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	12135494	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	19965390	RGD
involved in negative regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	19965390	RGD
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	1322410	RGD
involved in protein import into nucleus	IDA IDA: Inferred from direct assay	21273244	RGD
involved in response to amphetamine	IEP IEP: Inferred from expression pattern	11954050	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of calcineurin complex	IDA IDA: Inferred from direct assay	12135494	RGD
located in slit diaphragm	IDA IDA: Inferred from direct assay	27009276	RGD
is active in synapse	IDA IDA: Inferred from direct assay	1313851	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein phosphatase 3 catalytic subunit alpha

serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

CAM-PRP catalytic subunit	CNA alpha
Calcineurin subunit A alpha	calcineurin A alpha
protein phosphatase 3, catalytic subunit, alpha isozyme	protein phosphatase-2Ba

Ppp3ca Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ppp3ca	P63329	Cacna1c	Rattus norvegicus	P22002	Phosphatase Assay	19478199
Intra	Ppp3ca	P63329	Cacna1c	Rattus norvegicus	P22002	CoIP	19478199
Intra	Ppp3ca	P63329	Cacng8	Rattus norvegicus	Q8VHW5	Anti Bait CoIP	24418105

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11023	PPP3CA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppp3ca	NCBI	NCBI:5530

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