Bcl2l1 - Bcl2-like 1 Gene

Rattus norvegicus

Also known as Bclx; Bcl2l; bcl-X; Bcl-xl

Gene ID: 24888 | Gene type: protein coding

About Bcl2l1

Primary_assembly 3: 141,253,523-141,303,479 reverse strand.mRatBN7.2:CM026976.1

This gene has 3 transcripts (splice variants), 183 orthologues, 13 paralogues and is associated with 65 phenotypes. Biased expression in Thymus (RPKM 183.6), Kidney (RPKM 139.6) and 9 other tissues.

Summary

Enables several functions, including GTPase binding activity; MDM2/MDM4 family protein binding activity; and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and positive regulation of transport. Located in cytosol; mitochondrial outer membrane; and presynapse. Colocalizes with clathrin-coated pit; mitochondrial membrane; and synaptic vesicle membrane. Used to study amyotrophic lateral sclerosis; artery disease (multiple); endometriosis; gastric ulcer; and impotence. Biomarker of several diseases, including acute kidney failure; brain ischemia; mental depression; ocular hypertension; and status epilepticus. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); leukemia (multiple); pancreatic cancer; and stomach Cancer. Orthologous to human BCL2L1 (BCL2 like 1). [provided by Alliance of Genome Resources, Apr 2022]

Bcl2l1 Products(4)

mRNA	Protein	Name
NM_031535.2	NP_113723.2	bcl-2-like protein 1 isoform 1
NM_001033671.1	NP_001028843.1	bcl-2-like protein 1 isoform 3
NM_001033670.1	NP_001028842.1	bcl-2-like protein 1 isoform 2
NM_001033672.1	NP_001028844.1	bcl-2-like protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables BH domain binding	IPI IPI: Inferred from physical interaction	9356461	RGD
enables GTPase binding	IPI IPI: Inferred from physical interaction	23792689	RGD
enables MDM2/MDM4 family protein binding	IPI IPI: Inferred from physical interaction	17060322	RGD
enables clathrin binding	IPI IPI: Inferred from physical interaction	23792689	RGD
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IDA IDA: Inferred from direct assay	12097494	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9731710	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	9356461	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to astaxanthin	IEP IEP: Inferred from expression pattern	22889354	RGD
involved in cellular response to cAMP	IEP IEP: Inferred from expression pattern	22158476	RGD
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	12904174	RGD
involved in cellular response to erythropoietin	IEP IEP: Inferred from expression pattern	22293409	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	20669351	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	20798690	RGD
involved in cellular response to nitric oxide	IEP IEP: Inferred from expression pattern	25726415	RGD
involved in cellular response to prolactin	IEP IEP: Inferred from expression pattern	12904174	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	21937453	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18483861	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	9813151	RGD
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	12097494	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	22382519	RGD
involved in ovarian follicle development	IMP IMP: Inferred from mutant phenotype	17989359	RGD
involved in positive regulation of ATP biosynthetic process	IMP IMP: Inferred from mutant phenotype	23792689	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	22158476	RGD
involved in positive regulation of synaptic vesicle clustering	IMP IMP: Inferred from mutant phenotype	23792689	RGD
involved in positive regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	23792689	RGD
involved in positive regulation of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	23792689	RGD
involved in regulation of apoptotic process	IDA IDA: Inferred from direct assay	12515824	RGD
involved in regulation of long-term synaptic depression	IMP IMP: Inferred from mutant phenotype	23792689	RGD
involved in regulation of synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	23792689	RGD
involved in regulation of synaptic vesicle endocytosis	IEP IEP: Inferred from expression pattern	23792689	RGD
involved in regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	23792689	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	17700647	RGD
involved in response to endoplasmic reticulum stress	IEP IEP: Inferred from expression pattern	20798690	RGD
involved in response to erythropoietin	IEP IEP: Inferred from expression pattern	18838949	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	17869087	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	17272823	RGD
involved in response to ischemia	IDA IDA: Inferred from direct assay	21410437	RGD
involved in response to lead ion	IEP IEP: Inferred from expression pattern	17912701	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	18838949	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	17805306	RGD
involved in response to oxidative stress	IEP IEP: Inferred from expression pattern	12721309	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	17728251	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	11931842	RGD
involved in synaptic vesicle recycling via endosome	IMP IMP: Inferred from mutant phenotype	23792689	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	23792689	RGD
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	23792689	RGD
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	12515824	RGD
located in presynapse	IDA IDA: Inferred from direct assay	23792689	RGD
is active in synaptic vesicle	IDA IDA: Inferred from direct assay	23792689	RGD
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	23792689	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bcl2l1 Protein Structure

bcl-2

0
100
200
284 a.a.

Protein Preferred Names

Protein Names

bcl-2-like protein 1

B cell lymphoma 2 like	B cell lymphoma like X
apoptosis regulator Bcl-X	bcl2-L-1

Related Agents

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Purity	Phase
HY-10969	Obatoclax Mesylate	99.85%	Phase 3
HY-10969A	Obatoclax	≥99.0%	Phase 3
HY-15464A	(R)-(-)-Gossypol acetic acid	98.93%	Phase 2
HY-15464	(R)-(-)-Gossypol	98.82%	Phase 2

Pre-clinical Phase

Bioactive Molecules (26)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125876	PROTAC Bcl2 degrader-1	Inhibitor	99.80%	Unkown
HY-132307	Mcl-1 inhibitor 6		98.40%	Unkown
HY-15191B	(S)-Sabutoclax	Inhibitor	98.03%	Unkown
HY-114310	VDR agonist 1		/	Unkown
HY-135273	A-1211212		/	Unkown
HY-19551	Apogossypolone		/	Unkown
HY-118925	Holothurin A	Inhibitor	/	Unkown
HY-144428	Bcl-2/Mcl-1-IN-2	Inhibitor	/	Unkown
HY-144430	Bcl-2/Mcl-1-IN-1	Inhibitor	/	Unkown
HY-144431	Bcl-2/Mcl-1-IN-3	Inhibitor	/	Unkown
HY-147826	EGFR-IN-60		/	Unkown
HY-149436	CDK2/Bcl2-IN-1	Inhibitor	/	Unkown
HY-156877	Bcl-2-IN-16		/	Unkown
HY-159513	Bcl-2/Mcl-1-IN-4	Inhibitor	/	Unkown
HY-161415	BCL-xL/BCL-2 ligand 1		/	Unkown
HY-169083	Bcl-2-IN-22	Inhibitor	/	Unkown
HY-N3828	epi-Eriocalyxin A		/	Unkown
HY-RS01418	BCL2A1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS01419	Bcl2a1 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS01420	Bcl2a1a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01421	BCL2L1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS01422	Bcl2l1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS01423	Bcl2l1 Rat Pre-designed siRNA Set A		/	Unkown
HY-12011A	(Rac)-HA14-1	Inhibitor	/	Unkown
HY-123715	Anticancer agent 255		/	Unkown
HY-N8579	Eugenyl benzoate		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bcl2l1	NCBI	NCBI:598

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