(S)-Sabutoclax (Synonyms: (S)-BI-97C1)

Cat. No.: HY-15191B Purity: 98.03%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

(S)-Sabutoclax ((S)-BI-97C1), an optically pure apogossypol derivative, is pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. (S)-Sabutoclax (Compound II) inhibits the binding of BH3 peptides to Bcl-XL, Bcl-2, Mcl-1, and Bfl-1 with IC₅₀ values of 0.31, 0.32, 0.20, and 0.62 μM, respectively. (S)-Sabutoclax also potently inhibits cell growth of human prostate cancer, lung cancer, and lymphoma cell lines with EC₅₀ values of 0.13, 0.56, and 0.049 μM, respectively. (S)-Sabutoclax can be used for the research of apoptosis-based therapies against cancer.

For research use only. We do not sell to patients.

(S)-Sabutoclax Chemical Structure

CAS No. : 1228178-73-1

Size	Price	Stock	Quantity
5 mg	USD 390	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 624	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of (S)-Sabutoclax:

Sabutoclax Get quote

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View All Bcl-2 Family Isoform Specific Products:

View All Isoforms

Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC50: 0.31 μM (Bcl-XL), 0.32 μM (Bcl-2), 0.20 μM (Mcl-1), 0.62 μM (Bfl-1); EC50: 0.13 (human prostate cancer cell lines), 0.56 (lung cancer cell lines), 0.049 μM (lymphoma cell lines)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H460	EC₅₀	0.42 μM Compound: (R,-,R)-11, atropisoer	Cytotoxicity against human H460 cells after 3 days by ATP-LITE assay Cytotoxicity against human H460 cells after 3 days by ATP-LITE assay	[PMID: 20443627]
NCI-H460	EC₅₀	0.78 μM Compound: (R, +, R)-12	Cytotoxicity against human H460 cells after 3 days by ATP-LITE assay Cytotoxicity against human H460 cells after 3 days by ATP-LITE assay	[PMID: 20443627]
PC-3	EC₅₀	0.13 μM Compound: (R,-,R)-11, atropisoer	Cytotoxicity against human PC3 cells after 3 days by ATP-LITE assay Cytotoxicity against human PC3 cells after 3 days by ATP-LITE assay	[PMID: 20443627]
PC-3	EC₅₀	4.64 μM Compound: (R, +, R)-12	Cytotoxicity against human PC3 cells after 3 days by ATP-LITE assay Cytotoxicity against human PC3 cells after 3 days by ATP-LITE assay	[PMID: 20443627]

Molecular Weight

732.84

Formula

C₄₂H₄₂N₂O₈S

CAS No.

1228178-73-1

Appearance

Solid

Color

Light yellow to brown

SMILES

O=C(C1=C(O)C(O)=CC2=C(O)[C@]([C@]3=C(C)C=C4C(C(NC[C@@H](C5=CC=CC=C5)C)=O)=C(O)C(O)=CC4=C3O)=C(C)C=C12)NC[C@@H](C6=CC=CC=C6)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 30 mg/mL (40.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3646 mL	6.8228 mL	13.6455 mL
5 mM	0.2729 mL	1.3646 mL	2.7291 mL
10 mM	0.1365 mL	0.6823 mL	1.3646 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 3 mg/mL (4.09 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 3 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.03%

Select Batch:

Data Sheet (275 KB) SDS (251 KB)

COA (254 KB) HNMR (263 KB) RP-HPLC (257 KB)

Handling Instructions (2659 KB)

References

[1]. Wei J, et al. BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. J Med Chem. 2010 May 27;53(10):4166-76. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3646 mL	6.8228 mL	13.6455 mL	34.1139 mL
	5 mM	0.2729 mL	1.3646 mL	2.7291 mL	6.8228 mL
	10 mM	0.1365 mL	0.6823 mL	1.3646 mL	3.4114 mL
	15 mM	0.0910 mL	0.4549 mL	0.9097 mL	2.2743 mL
	20 mM	0.0682 mL	0.3411 mL	0.6823 mL	1.7057 mL
	25 mM	0.0546 mL	0.2729 mL	0.5458 mL	1.3646 mL
	30 mM	0.0455 mL	0.2274 mL	0.4549 mL	1.1371 mL
	40 mM	0.0341 mL	0.1706 mL	0.3411 mL	0.8528 mL

(S)-Sabutoclax Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-Sabutoclax1228178-73-1(S)-BI-97C1Bcl-2 FamilyapogossypolantiapoptoticB-cell lymphoma/leukemia-2 (Bcl-2) familycancerInhibitorinhibitorinhibit

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