Esr1 - estrogen receptor 1 Gene

Rattus norvegicus

Also known as Esr; ER-alpha; RNESTROR

Gene ID: 24890 | Gene type: protein coding

About Esr1

Primary_assembly 1: 41,210,475-41,495,002 forward strand.mRatBN7.2:CM026974.1

This gene has 10 transcripts (splice variants), 212 orthologues, 8 paralogues and is associated with 104 phenotypes. Biased expression in Uterus (RPKM 235.5), Kidney (RPKM 77.3) and 7 other tissues.

Summary

Enables several functions, including phosphatidylinositol 3-kinase regulatory subunit binding activity; promoter-specific chromatin binding activity; and transcription coactivator binding activity. Involved in several processes, including cellular response to lipid; regulation of neuron death; and reproductive structure development. Located in several cellular components, including T-tubule; perikaryon; and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study several diseases, including Parkinsonism; infertility; obesity; pleurisy; and prostate disease (multiple). Biomarker of cryptorchidism; osteoporosis; and ovarian Cancer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); breast Cancer (multiple); type 2 diabetes mellitus; and vitiligo. Orthologous to human ESR1 (Estrogen Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Esr1 Products(1)

mRNA	Protein	Name
NM_012689.1	NP_036821.1	estrogen receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IMP IMP: Inferred from mutant phenotype	12372009	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	19422801	RGD
enables hormone binding	IDA IDA: Inferred from direct assay	17928626	RGD
enables hormone binding	IMP IMP: Inferred from mutant phenotype	15105439	RGD
enables nuclear steroid receptor activity	IDA IDA: Inferred from direct assay	17928626	RGD
enables phosphatidylinositol 3-kinase regulatory subunit binding	IPI IPI: Inferred from physical interaction	16971528	RGD
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	24046281	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11818503	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	18434427	RGD
enables steroid binding	IDA IDA: Inferred from direct assay	15705806	RGD
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	18511507	RGD
enables type 1 metabotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	18948402	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in Sertoli cell development	IEP IEP: Inferred from expression pattern	24056172	RGD
involved in Sertoli cell proliferation	IMP IMP: Inferred from mutant phenotype	17928626	RGD
involved in baculum development	IEP IEP: Inferred from expression pattern	21471296	RGD
involved in cellular response to estradiol stimulus	IDA IDA: Inferred from direct assay	15705806	RGD
involved in cellular response to estrogen stimulus	IEP IEP: Inferred from expression pattern	17272396	RGD
involved in cellular response to wortmannin	IEP IEP: Inferred from expression pattern	17272396	RGD
involved in decidualization	IEP IEP: Inferred from expression pattern	21248290	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	20951417	RGD
involved in negative regulation of D-glucose import	IDA IDA: Inferred from direct assay	23871901	RGD
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	15126114	RGD
involved in negative regulation of smooth muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	21808025	RGD
involved in negative regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	22099601	RGD
involved in negative regulation of triglyceride metabolic process	IDA IDA: Inferred from direct assay	23871901	RGD
involved in nuclear receptor-mediated steroid hormone signaling pathway	IDA IDA: Inferred from direct assay	15705806	RGD
involved in osteoblast development	IEP IEP: Inferred from expression pattern	9528993	RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	15705806	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	17928626	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	15705806	RGD
involved in positive regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17928626	RGD
involved in positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	25004094	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	9528993	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IDA IDA: Inferred from direct assay	16876190	RGD
located in nucleus	IDA IDA: Inferred from direct assay	15705806	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	16122717	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	17928626	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	18434427	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	17314305	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Esr1 Protein Structure

Oest_recep

NR_DBD_ER

NR_LBD_ER

ESR1_C

0
200
400
600
665 a.a.

Protein Preferred Names

Protein Names

estrogen receptor

C-terminally-truncated estrogen receptor alpha product-1	Er alpha
estradiol receptor	estrogen receptor 1 (alpha)
estrogen receptor alpha i45aL	estrogen receptor alpha i45aS
estrogen receptor alpha i45c	estrogen receptor alpha i56a
estrogen receptor alpha i56b	estrogen receptor alpha i56c
estrogen receptor alpha i56dL	estrogen receptor alpha i56dS
estrogen receptor alpha i56e	estrogen receptor alpha variant delta 4
estrogen receptor protein	nuclear receptor subfamily 3 group A member 1
trunctaed

Esr1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Esr1	P06211	Rps27a	Rattus norvegicus	P62989	Anti Bait CoIP	21808025
Intra	Esr1	P06211	St13	Rattus norvegicus	P50503	Anti Bait CoIP	21808025

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-136255	Camizestrant	Inhibitor	98.04%	Phase 3

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-147165	VT02956	Inhibitor	99.58%	Unkown
HY-101119	GLL398	Degrader	/	Unkown
HY-149480	ERD-3111	Degrader	/	Unkown
HY-RS04529	ESR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04530	Esr1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04531	Esr1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-147165A	VT02956 hydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Esr1	NCBI	NCBI:2099

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