Fgfr2 - fibroblast growth factor receptor 2 Gene

Rattus norvegicus

Gene ID: 25022 | Gene type: protein coding

About Fgfr2

Primary_assembly 1: 184,745,420-184,850,626 reverse strand.mRatBN7.2:CM026974.1

This gene has 4 transcripts (splice variants), 221 orthologues, 54 paralogues and is associated with 75 phenotypes. Biased expression in Adrenal (RPKM 15.3), Lung (RPKM 131.4) and 9 other tissues.

Summary

Enables Fibroblast Growth Factor binding activity and fibroblast growth factor-activated receptor activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to retinoic acid; and positive regulation of smooth muscle cell proliferation. Located in cell surface; cytoplasm; and nucleus. Used to study prostate Cancer and retinitis pigmentosa. Biomarker of hypospadias. Human ortholog(s) of this gene implicated in several diseases, including Beare-Stevenson cutis gyrata syndrome; Jackson-Weiss syndrome; LADD syndrome; dysgerminoma; and synostosis (multiple). Orthologous to human FGFR2 (Fibroblast Growth Factor receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Fgfr2 Products(6)

mRNA	Protein	Name
NM_001109892.1	NP_001103362.1	fibroblast growth factor receptor 2 isoform b
NM_001109895.1	NP_001103365.1	fibroblast growth factor receptor 2 isoform e
NM_001109896.1	NP_001103366.1	fibroblast growth factor receptor 2 isoform f
NM_001109893.1	NP_001103363.1	fibroblast growth factor receptor 2 isoform c
NM_001109894.1	NP_001103364.1	fibroblast growth factor receptor 2 isoform d
NM_012712.1	NP_036844.1	fibroblast growth factor receptor 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fibroblast growth factor binding	IDA IDA: Inferred from direct assay	15282342	RGD
enables fibroblast growth factor binding	IPI IPI: Inferred from physical interaction	7803853	RGD
enables fibroblast growth factor receptor activity	IDA IDA: Inferred from direct assay	15282342	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to fibroblast growth factor stimulus	IEP IEP: Inferred from expression pattern	9373031	RGD
involved in cellular response to fibroblast growth factor stimulus	IMP IMP: Inferred from mutant phenotype	28981091	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	31093967	RGD
involved in cellular response to retinoic acid	IEP IEP: Inferred from expression pattern	15389522	RGD
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	12648559	RGD
involved in endochondral bone growth	IEP IEP: Inferred from expression pattern	17169623	RGD
involved in epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	7803853	RGD
involved in fibroblast growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	15282342	RGD
involved in fibroblast growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15292181	RGD
involved in mesodermal cell differentiation	IEP IEP: Inferred from expression pattern	7803853	RGD
involved in negative regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	9537256	RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	15292181	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	16770775	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	19524256	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	15614790	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Fgfr2 Protein Structure

IgI_2_FGFR

PTKc_FGFR2

0
200
400
600
841 a.a.

Protein Preferred Names

Protein Names

fibroblast growth factor receptor 2

Related Agents

Approval

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10981	Lenvatinib	Inhibitor	99.75%	Yes
HY-50904	Nintedanib	Inhibitor	99.94%	Yes
HY-18708	Erdafitinib	Inhibitor	99.66%	Unkown
HY-13311	Infigratinib	Inhibitor	99.72%	Yes
HY-109099	Pemigatinib	Inhibitor	99.84%	Yes
HY-100818	Futibatinib	Inhibitor	99.65%	Unkown
HY-11106	Nintedanib esylate	Inhibitor	99.95%	Yes
HY-10981A	Lenvatinib mesylate	Inhibitor	99.86%	Yes
HY-N0060	Ferulic acid	Inhibitor	99.87%	Yes
HY-13311A	Infigratinib phosphate	Inhibitor	99.74%	Yes

Clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13330	Fexagratinib	Inhibitor	99.85%	Phase 3
HY-100019	Rogaratinib	Inhibitor	99.86%	Phase 3
HY-15391	Lucitanib	Inhibitor	98.94%	Phase 3
HY-101568	Roblitinib	Inhibitor	99.74%	Phase 2
HY-13034	Gandotinib	Inhibitor	99.82%	Phase 2
HY-19981	Derazantinib	Inhibitor	99.28%	Phase 2
HY-10987A	ENMD-2076	Inhibitor	99.12%	Phase 2
HY-19957	Zoligratinib	Inhibitor	99.76%	Phase 2
HY-10987	ENMD-2076 Tartrate	Inhibitor	99.42%	Phase 2
HY-10186	TG 100801	Inhibitor	98.61%	Phase 2
HY-101466A	E7090 succinate	Inhibitor	99.17%	Phase 2
HY-10187	TG 100801 Hydrochloride	Inhibitor	/	Phase 2
HY-13304	LY2874455	Inhibitor	98.03%	Phase 1
HY-101768	PRN1371	Inhibitor	99.43%	Phase 1
HY-119367	ODM-203	Inhibitor	99.91%	Phase 1
HY-19983	ASP5878	Inhibitor	99.69%	Phase 1
HY-100491	H3B-6527	Inhibitor	≥98.0%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99007	Aprutumab	Inhibitor	96.50%	Phase 1

Pre-clinical Phase

Bioactive Molecules (43)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0183	Formononetin	Inhibitor	98.99%	Unkown
HY-147250	Lirafugratinib	Inhibitor	99.67%	Unkown
HY-12823	BLU9931	Inhibitor	99.97%	Unkown
HY-122704A	Surfen dihydrochloride	Inhibitor	≥99.0%	Unkown
HY-17601	Alofanib	Inhibitor	99.90%	Unkown
HY-18602	FIIN-2	Inhibitor	99.32%	Unkown
HY-15599	SSR128129E	Inhibitor	99.85%	Unkown
HY-148779	FGFR3-IN-5	Inhibitor	99.28%	Unkown
HY-145231	FGFR2-IN-2	Inhibitor	98.25%	Unkown
HY-10185	TG 100572 Hydrochloride	Inhibitor	98.96%	Unkown
HY-101466	E7090	Inhibitor	99.64%	Unkown
HY-147250A	Lirafugratinib hydrochloride	Inhibitor	98.73%	Unkown
HY-131908	CPL304110	Inhibitor	99.85%	Unkown
HY-149843	LC-MB12	Inhibitor	99.23%	Unkown
HY-15813	FIIN-1	Inhibitor	99.11%	Unkown
HY-18603	FIIN-3	Inhibitor	99.66%	Unkown
HY-12965	S49076	Inhibitor	99.44%	Unkown
HY-131704	FGFR4-IN-5	Inhibitor	98.03%	Unkown
HY-10184	TG 100572	Inhibitor	/	Unkown
HY-142921	FGFR-IN-2	Inhibitor	/	Unkown
HY-155028	FGFR-IN-11	Inhibitor	/	Unkown
HY-168286	FGFR-IN-16	Inhibitor	/	Unkown
HY-162865	FGFR2-IN-3	Inhibitor	/	Unkown
HY-158248	FGFR4-IN-19	Inhibitor	/	Unkown
HY-151903S	FGFR2/3-IN-1	Inhibitor	/	Unkown
HY-148597	FGFR-IN-10	Inhibitor	/	Unkown
HY-147713	FGFR3-IN-1	Inhibitor	/	Unkown
HY-150652	FGFR-IN-8	Inhibitor	/	Unkown
HY-141685	3-Methylthienyl-carbonyl-JNJ-7706621	Inhibitor	/	Unkown
HY-152104	FGFR-IN-9	Inhibitor	/	Unkown
HY-101544	ARQ 069	Inhibitor	/	Unkown
HY-162626	FGFR2 degrader 1	Degrader	/	Unkown
HY-N9507	Picrasidine Q	Inhibitor	/	Unkown
HY-163985	PROTAC FGFR2 degrader 1	Degrader	/	Unkown
HY-117595	PHM16	Inhibitor	/	Unkown
HY-145230	FGFR2-IN-1	Inhibitor	99.78%	Unkown
HY-147715	FGFR3-IN-3	Inhibitor	/	Unkown
HY-152146	HDAC-IN-50	Inhibitor	/	Unkown
HY-164459	AZ8010	Inhibitor	/	Unkown
HY-15599A	SSR128129E free acid	Inhibitor	/	Unkown
HY-159503A	Segigratinib hydrochloride	Inhibitor	/	Unkown
HY-15391A	Lucitanib dihydrochloride	Inhibitor	/	Unkown
HY-122704	Surfen	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fgfr2	NCBI	NCBI:2263

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