Ghr - growth hormone receptor Gene

Rattus norvegicus

Also known as GHR/BP

Gene ID: 25235 | Gene type: protein coding

About Ghr

Summary

Enables SH2 domain binding activity; Enzyme binding activity; and growth hormone receptor activity. Involved in several processes, including activation of Janus kinase activity; cellular response to hormone stimulus; and receptor signaling pathway via JAK-STAT. Located in several cellular components, including extracellular space; mitochondrion; and neuronal cell body. Biomarker of congenital hypothyroidism; muscular atrophy; osteopetrosis; and osteoporosis. Human ortholog(s) of this gene implicated in several diseases, including Laron syndrome; familial hypercholesterolemia; isolated growth hormone deficiency; osteoarthritis; and type 2 diabetes mellitus. Orthologous to human GHR (growth hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ghr Products(1)

mRNA	Protein	Name
NM_017094.2	NP_058790.1	growth hormone receptor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SH2 domain binding	IDA IDA: Inferred from direct assay	12586763	RGD
enables SH2 domain binding	IMP IMP: Inferred from mutant phenotype	10976913	RGD
enables SH2 domain binding	IPI IPI: Inferred from physical interaction	10976913	RGD
enables growth hormone receptor activity	IDA IDA: Inferred from direct assay	11244571	RGD
enables protein kinase binding	IDA IDA: Inferred from direct assay	8063815	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	11244571	RGD
enables protein phosphatase binding	IMP IMP: Inferred from mutant phenotype	10976913	RGD
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	10976913	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of Janus kinase activity	IDA IDA: Inferred from direct assay	11244571	RGD
involved in cartilage development involved in endochondral bone morphogenesis	IEP IEP: Inferred from expression pattern	15749813	RGD
involved in cell surface receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	8063815	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	18040895	RGD
involved in growth hormone receptor signaling pathway	IDA IDA: Inferred from direct assay	8063815	RGD
involved in hormone-mediated signaling pathway	IDA IDA: Inferred from direct assay	11064147	RGD
acts upstream of positive regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	8063815	RGD
involved in positive regulation of cell differentiation	IEP IEP: Inferred from expression pattern	12162495	RGD
involved in positive regulation of receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	11064147	RGD
involved in positive regulation of receptor signaling pathway via JAK-STAT	IMP IMP: Inferred from mutant phenotype	10976913	RGD
involved in regulation of response to nutrient levels	IMP IMP: Inferred from mutant phenotype	17258692	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	12654216	RGD
involved in response to food	IEP IEP: Inferred from expression pattern	17634149	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	12162495	RGD
involved in response to gravity	IEP IEP: Inferred from expression pattern	14638460	RGD
involved in response to growth hormone	IEP IEP: Inferred from expression pattern	10987684	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	12162495	RGD
involved in response to interleukin-1	IEP IEP: Inferred from expression pattern	14518239	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	15334695	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	11126270	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	17258692	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

growth hormone receptor

GH receptor	growth hormone receptor variant d5-6
growth hormone receptor/binding protein	somatotropin receptor

Recombinant Ghr Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73088	Growth Hormone R/GHR Protein, Rat (HEK293, Fc)	P16310-1 (F19-R265)	≥95%
HY-P73089	Growth Hormone R/GHR Protein, Rat (HEK293, His)	P16310-1 (F19-R265)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-164419A	Atesidorsen sodium	Inhibitor	98.58%	Phase 2
HY-153485	Cimdelirsen	Inhibitor	/	Phase 2
HY-153485A	Cimdelirsen sodium	Inhibitor	/	Phase 2
HY-164419	Atesidorsen	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10283	S1H	Antagonist	99.29%	Unkown
HY-159697	ISIS 532401		/	Unkown
HY-159697A	ISIS 532401 sodium		/	Unkown
HY-RS05412	GHR Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ghr	NCBI	NCBI:2690
Mus musculus	Ghr	NCBI	NCBI:14600
Macaca mulatta	Ghr	NCBI	NCBI:697986

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