2. Gene
  3. Ghr - growth hormone receptor Gene

Ghr - growth hormone receptor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as GHBP; GHR/BP

Gene ID: 14600 | Gene type: protein coding

About Ghr

Summary

Enables growth hormone receptor activity and peptide hormone binding activity. Involved in growth hormone receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of growth. Acts upstream of or within taurine metabolic process. Located in nucleus and plasma membrane. Is extrinsic component of membrane. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and integumental system. Used to study Laron syndrome. Human ortholog(s) of this gene implicated in several diseases, including Laron syndrome; familial hypercholesterolemia; isolated growth hormone deficiency; osteoarthritis; and type 2 diabetes mellitus. Orthologous to human GHR (growth hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ghr Products(3)

mRNA Protein Name
NM_001048178.2 NP_001041643.1 growth hormone receptor isoform 2 precursor
NM_001286370.1 NP_001273299.1 growth hormone receptor isoform 1 precursor
NM_010284.3 NP_034414.2 growth hormone receptor isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables growth hormone receptor activity IDA
IDA: Inferred from direct assay
6303755 MGI
enables peptide hormone binding IPI
IPI: Inferred from physical interaction
10556780 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8702683 MGI
Biological Process GO Annotation Evidence Reference Source
involved in growth hormone receptor signaling pathway IDA
IDA: Inferred from direct assay
8702683 MGI
involved in positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
8702683 MGI
involved in regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
18648510 MGI
acts upstream of positive effect taurine metabolic process IMP
IMP: Inferred from mutant phenotype
18648510 MGI
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
11834450 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9144201 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
9144201 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

growth hormone receptor

GH receptor

Growth hormone receptor precursor (GH receptor) (GH binding protein) (GHBP) (Serum binding protein)

growth hormone receptor/binding protein, high molecular weight

growth hormone receptor/binding protein, low molecular weight

somatotropin r

Recombinant Ghr Proteins

Cat. No. Product Name Accession Purity
HY-P70850 Growth Hormone R/GHR Protein, Mouse (HEK293, Fc) Q3UP14 (M1-Q273) ≥95%
HY-P73086 Growth Hormone R/GHR Protein, Mouse (HEK293, His-Fc) P16882/NP_034414.2 (T25-Q273) ≥95%
HY-P73087 Growth Hormone R/GHR Protein, Mouse (HEK293, His) P16882/NP_034414.2 (T25-Q273) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-164419A Atesidorsen sodium Inhibitor 91.84% Phase 2
HY-153485 Cimdelirsen Inhibitor / Phase 2
HY-153485A Cimdelirsen sodium Inhibitor / Phase 2
HY-164419 Atesidorsen Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P10283 S1H Antagonist / Unkown
HY-RS05412 GHR Human Pre-designed siRNA Set A / Unkown
HY-159697 ISIS 532401 / Unkown
HY-159697A ISIS 532401 sodium / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ghr NCBI NCBI:2690
Rattus norvegicus Ghr NCBI NCBI:25235
Macaca mulatta Ghr NCBI NCBI:697986