Bcar1 - BCAR1 scaffold protein, Cas family member Gene

Rattus norvegicus

Also known as Cas; Crkas; P130CAS

Gene ID: 25414 | Gene type: protein coding

About Bcar1

Summary

Enables protein domain specific binding activity. Involved in several processes, including cellular response to endothelin; cellular response to nitric oxide; and transmembrane receptor protein tyrosine kinase signaling pathway. Located in focal adhesion and plasma membrane. Human ortholog(s) of this gene implicated in breast ductal carcinoma. Orthologous to human BCAR1 (BCAR1 scaffold protein, Cas family member). [provided by Alliance of Genome Resources, Apr 2022]

Bcar1 Products(3)

mRNA	Protein	Name
NM_001395122.1	NP_001382051.1	breast cancer anti-estrogen resistance protein 1 isoform 1
NM_001395123.1	NP_001382052.1	breast cancer anti-estrogen resistance protein 1 isoform 2
NM_012931.2	NP_037063.2	breast cancer anti-estrogen resistance protein 1 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	8940134	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	12011056	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	12011056	RGD
involved in cell migration	IMP IMP: Inferred from mutant phenotype	12011056	RGD
involved in cellular response to endothelin	IPI IPI: Inferred from physical interaction	12719447	RGD
involved in cellular response to nitric oxide	IPI IPI: Inferred from physical interaction	12714323	RGD
involved in epidermal growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	9325334	RGD
involved in insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	9627109	RGD
involved in negative regulation of substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	15817476	RGD
involved in neurotrophin TRK receptor signaling pathway	IDA IDA: Inferred from direct assay	8631760	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in focal adhesion	IDA IDA: Inferred from direct assay	8662921	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

breast cancer anti-estrogen resistance protein 1

BCAR1, Cas family scaffold protein	BCAR1, Cas family scaffolding protein
CRK-associated substrate	breast cancer anti-estrogen resistance 1
v-crk-associated tyrosine kinase substrate

Bcar1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Bcar1	Q63767	PTPN1	Homo sapiens	P18031	Pull Down	8940134

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01397	BCAR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bcar1	NCBI	NCBI:9564

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