EPGN - epithelial mitogen Gene

Homo sapiens

Also known as EPG; PRO9904; ALGV3072

Gene ID: 255324 | Gene type: protein coding

About EPGN

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:74,308,470-74,316,789 (from NCBI)

This gene has 9 transcripts (splice variants), 110 orthologues and 5 paralogues. Restricted expression toward esophagus (RPKM 11.2).

Summary

The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in Cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

EPGN Products(6)

mRNA	Protein	Name
NM_001013442.2	NP_001013460.1	epigen isoform 6 precursor
NM_001270989.2	NP_001257918.1	epigen isoform 1 precursor
NM_001270990.2	NP_001257919.1	epigen isoform 2 precursor
NM_001270991.2	NP_001257920.1	epigen isoform 3 precursor
NM_001270992.2	NP_001257921.1	epigen isoform 4 precursor
NM_001270993.2	NP_001257922.1	epigen isoform 5 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables epidermal growth factor receptor binding	IPI IPI: Inferred from physical interaction	15611079	GOA
enables growth factor activity	IDA IDA: Inferred from direct assay	15611079	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28988771	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis	IDA IDA: Inferred from direct assay	15611079	GOA
involved in epidermal growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	15611079	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	15611079	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15611079	GOA
involved in positive regulation of mitotic nuclear division	IDA IDA: Inferred from direct assay	15611079	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	15611079	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

epigen

epithelial mitogen homolog

EPGN Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EPGN	Q6UW88	EGFR	Homo sapiens	P00533	SAXS	28988771

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EPGN Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7010	Epigen Protein, Human	Q6UW88-2 (A24-A95)	≥95%
HY-P7010A	Epigen Protein, Human (CHO)	Q6UW88-2 (A24-A104)	≥95%

Related Diseases

Diseases

Alias

Vallecula Cancer

Malignant Tumor Of Vallecula

Bronchiectasis 2

Proliferative Glomerulonephritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04423	EPGN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EPGN	RGD	RGD:1560084
Bos taurus	EPGN	VGNC	VGNC:53711
Felis catus	EPGN	VGNC	VGNC:107331
Mus musculus	EPGN	MGD	MGI:1919170
Canis familiaris	EPGN	VGNC	VGNC:40403
Macaca mulatta	EPGN	VGNC	VGNC:72061

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