Ppp1cb - protein phosphatase 1 catalytic subunit beta Gene

Rattus norvegicus

Also known as PP1B; PP1beta

Gene ID: 25594 | Gene type: protein coding

About Ppp1cb

Summary

Enables phosphoprotein Phosphatase activity. Involved in protein dephosphorylation; regulation of glycogen biosynthetic process; and regulation of glycogen catabolic process. Located in glycogen granule. Part of protein Phosphatase type 1 complex. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 2. Orthologous to human PPP1CB (protein Phosphatase 1 catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Ppp1cb Products(1)

mRNA	Protein	Name
NM_013065.2	NP_037197.1	serine/threonine-protein phosphatase PP1-beta catalytic subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphoprotein phosphatase activity	IDA IDA: Inferred from direct assay	7720853	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	7649987	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	7720853	RGD
involved in regulation of glycogen biosynthetic process	IDA IDA: Inferred from direct assay	7720853	RGD
involved in regulation of glycogen catabolic process	IDA IDA: Inferred from direct assay	7720853	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in glycogen granule	IDA IDA: Inferred from direct assay	7720853	RGD
part of protein phosphatase type 1 complex	IDA IDA: Inferred from direct assay	7720853	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase PP1-beta catalytic subunit

PP-1B	protein phosphatase 1, catalytic subunit, beta isozyme
protein phosphatase-1a

Ppp1cb Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ppp1cb	P62142	Ppp1r9a	Rattus norvegicus	O35867	Anti Tag CoIP	18216290
Intra	Ppp1cb	P62142	Rpl5	Rattus norvegicus	P09895	Y2H	7649987

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10974	PPP1CB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppp1cb	NCBI	NCBI:5500

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