Mc4r - melanocortin 4 receptor Gene

Rattus norvegicus

Gene ID: 25635 | Gene type: protein coding

About Mc4r

Primary_assembly 18: 60,419,832-60,421,719 reverse strand.mRatBN7.2:CM026991.1

This gene has 1 transcript (splice variant), 231 orthologues, 18 paralogues and is associated with 44 phenotypes.

Summary

Enables Melanocortin Receptor activity and peptide hormone binding activity. Involved in several processes, including diet induced thermogenesis; negative regulation of feeding behavior; and regulation of grooming behavior. Located in nucleus and plasma membrane. Used to study obesity. Biomarker of obesity and sciatic neuropathy. Human ortholog(s) of this gene implicated in morbid obesity and obesity. Orthologous to human MC4R (melanocortin 4 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Mc4r Products(1)

mRNA	Protein	Name
NM_013099.3	NP_037231.1	melanocortin receptor 4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables hormone binding	IDA IDA: Inferred from direct assay	21527895	RGD
enables melanocortin receptor activity	IDA IDA: Inferred from direct assay	17023527	RGD
enables melanocortin receptor activity	IMP IMP: Inferred from mutant phenotype	17023527	RGD
enables peptide hormone binding	IDA IDA: Inferred from direct assay	17023527	RGD
enables peptide hormone binding	IMP IMP: Inferred from mutant phenotype	17023527	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in diet induced thermogenesis	IDA IDA: Inferred from direct assay	14988515	RGD
involved in energy reserve metabolic process	IDA IDA: Inferred from direct assay	14988515	RGD
involved in feeding behavior	IDA IDA: Inferred from direct assay	14988515	RGD
involved in negative regulation of feeding behavior	IMP IMP: Inferred from mutant phenotype	20118207	RGD
involved in regulation of feeding behavior	IMP IMP: Inferred from mutant phenotype	21527895	RGD
involved in regulation of grooming behavior	IMP IMP: Inferred from mutant phenotype	21527895	RGD
involved in response to bisphenol A	IEP IEP: Inferred from expression pattern	35945320	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mc4r Protein Structure

7tmA_MC4R

0
100
200
300
332 a.a.

Protein Preferred Names

Protein Names

melanocortin receptor 4

MC4-R

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18678A	Bremelanotide Acetate	Agonist	99.98%	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P0252	α-MSH	Agonist	99.81%	Phase 2
HY-118930	MK-0493	Agonist	99.43%	Phase 2
HY-10622	PF-00446687 free base	Agonist	98.02%	Phase 2
HY-148349	PF-07258669	Antagonist	98.44%	Phase 1

Pre-clinical Phase

Bioactive Molecules (21)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0227	SHU 9119		99.95%	Unkown
HY-10624	THIQ	Agonist	98.28%	Unkown
HY-P0097A	Nonapeptide-1 acetate salt	Antagonist	98.70%	Unkown
HY-P0252A	α-MSH TFA	Agonist	98.79%	Unkown
HY-P1504A	β-Melanocyte Stimulating Hormone (MSH), human TFA	Agonist	99.51%	Unkown
HY-P1215A	HS024 TFA	Antagonist	99.80%	Unkown
HY-11030A	SNT-207858 free base	Antagonist	99.66%	Unkown
HY-110123	ML-00253764 hydrochloride	Inhibitor	99.47%	Unkown
HY-P2242A	RO27-3225 TFA	Agonist	99.21%	Unkown
HY-P1478	Adrenocorticotropic Hormone (ACTH) (4-10), human	Agonist	99.23%	Unkown
HY-P1504	β-Melanocyte Stimulating Hormone (MSH), human	Agonist	98.91%	Unkown
HY-P1208	PG-931	Agonist	99.81%	Unkown
HY-P1213	JKC363	Antagonist	99.55%	Unkown
HY-P0097	Nonapeptide-1	Antagonist	99.04%	Unkown
HY-P1216A	HS014 TFA	Antagonist	99.87%	Unkown
HY-P1216	HS014	Antagonist	/	Unkown
HY-P1208A	PG-931 TFA	Agonist	/	Unkown
HY-169731	RO27-3225 trifluoroacetate	Agonist	/	Unkown
HY-P0252B	α-MSH free acid	Agonist	/	Unkown
HY-P3561	Agouti-related Protein (AGRP) (83-132) Amide (human)	Antagonist	/	Unkown
HY-P1213A	JKC363 TFA	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mc4r	NCBI	NCBI:4160

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