Hmgcr - 3-hydroxy-3-methylglutaryl-CoA reductase Gene

Rattus norvegicus

Also known as 3H3M

Gene ID: 25675 | Gene type: protein coding

About Hmgcr

Primary_assembly 2: 27,997,525-28,019,703 reverse strand.mRatBN7.2:CM026975.1

This gene has 4 transcripts (splice variants), 206 orthologues and is associated with 39 phenotypes. Biased expression in Liver (RPKM 17.6), Brain (RPKM 11.7) and 9 other tissues.

Summary

Enables identical protein binding activity and protein Phosphatase 2A binding activity. Involved in several processes, including lipid homeostasis; positive regulation of MAPK cascade; and regulation of striated muscle cell apoptotic process. Located in intracellular membrane-bounded organelle. Used to study Wilson disease; drug-induced hepatitis; end stage renal disease; pulmonary hypertension; and type 2 diabetes mellitus. Biomarker of chronic kidney disease; non-alcoholic fatty liver disease; and premature menopause. Human ortholog(s) of this gene implicated in several diseases, including asthma; coronary artery disease (multiple); dementia; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). [provided by Alliance of Genome Resources, Apr 2022]

Hmgcr Products(1)

mRNA	Protein	Name
NM_013134.2	NP_037266.2	3-hydroxy-3-methylglutaryl-coenzyme A reductase

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	4019513	RGD
enables protein phosphatase 2A binding	IPI IPI: Inferred from physical interaction	18031790	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cholesterol homeostasis	IEP IEP: Inferred from expression pattern	23117815	RGD
involved in myoblast differentiation	IEP IEP: Inferred from expression pattern	20336669	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15385411	RGD
involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	20610886	RGD
involved in negative regulation of striated muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	19505369	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	17161379	RGD
involved in positive regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	19298698	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12713866	RGD
involved in positive regulation of skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	19388010	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	18413661	RGD
involved in positive regulation of stress-activated MAPK cascade	IMP IMP: Inferred from mutant phenotype	17161379	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	19221211	RGD
involved in response to cholesterol	IEP IEP: Inferred from expression pattern	25263431	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	20041784	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	16702306	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	23117815	RGD
involved in triglyceride homeostasis	IEP IEP: Inferred from expression pattern	23117815	RGD
involved in ubiquinone metabolic process	IMP IMP: Inferred from mutant phenotype	17192694	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hmgcr Protein Structure

2A060605

0
200
400
600
800
897 a.a.

Protein Preferred Names

Protein Names

3-hydroxy-3-methylglutaryl-coenzyme A reductase

HMG-CoA reductase

Related Agents

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17504	Rosuvastatin Calcium		99.77%	Yes
HY-17504B	Rosuvastatin Sodium		99.85%	Yes
HY-119695A	Simvastatin acid ammonium	Inhibitor	99.70%	Unkown
HY-115292	Simvastatin hydroxy acid sodium	Inhibitor	≥99.0%	Unkown
HY-119695	Simvastatin acid	Inhibitor	/	Unkown
HY-119695B	Simvastatin acid calcium hydrate	Inhibitor	/	Unkown

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15483	DY131		99.72%	Unkown
HY-107855	DL-Mevalonolactone		99.15%	Unkown
HY-N0686	Pseudoprotodioscin	Inhibitor	98.76%	Unkown
HY-106281	Bemfivastatin	Inhibitor	99.48%	Unkown
HY-17504R	Rosuvastatin Calcium (Standard)		99.94%	Unkown
HY-114316	HMG499	Inhibitor	96.78%	Unkown
HY-101873S	Atorvastatin lactone-d5	Inhibitor	/	Unkown
HY-116241	L-157012	Inhibitor	/	Unkown
HY-119695AS1	Simvastatin acid-d9 ammonium	Inhibitor	/	Unkown
HY-147195	QH536	Inhibitor	/	Unkown
HY-N11637	Ganoderenic acid K	Inhibitor	/	Unkown
HY-RS06238	HMGCR Human Pre-designed siRNA Set A		/	Unkown
HY-RS06239	Hmgcr Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS06240	Hmgcr Rat Pre-designed siRNA Set A		/	Unkown
HY-17504BS2	Rosuvastatin-13C,d3 sodium		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hmgcr	NCBI	NCBI:3156

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