TAB3 - TGF-beta activated kinase 1 (MAP3K7) binding protein 3 Gene

Homo sapiens

Also known as NAP1; MAP3K7IP3

Gene ID: 257397 | Gene type: protein coding

About TAB3

Cytogenetic location: Xp21.2 Genomic coordinates (GRCh38): X:30,827,442-30,889,254 (from NCBI)

This gene has 6 transcripts (splice variants), 207 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 6.3), endometrium (RPKM 5.6) and 25 other tissues.

Summary

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

TAB3 Products(4)

mRNA	Protein	Name
NM_001399870.1	NP_001386799.1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 2
NM_001399872.1	NP_001386801.1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 3
NM_001399873.1	NP_001386802.1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 4
NM_152787.5	NP_690000.3	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables K63-linked polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	15327770	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	15327770	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17158449	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	22158122	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	18079694	GOA
involved in non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	15327770	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	15327770	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	23487264	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15327770	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAB3 Protein Structure

CUE

0
200
400
600
712 a.a.

Protein Preferred Names

Protein Names

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

NF-kappa-B-activating protein 1

TAB3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TAB3	Q8N5C8	CEP57L1	Homo sapiens	Q8IYX8-2	Y2H Prey Pooling	25416956
Intra	TAB3	Q8N5C8	CEP57L1	Homo sapiens	Q8IYX8-2	Y2H Array	25416956
Intra	TAB3	Q8N5C8	MAP3K7CL	Homo sapiens	P57077-4	Y2H Prey Pooling	25416956
Intra	TAB3	Q8N5C8	MAP3K7CL	Homo sapiens	P57077-4	Validated Y2H	25416956
Intra	TAB3	Q8N5C8	MAP3K7CL	Homo sapiens	P57077-4	Y2H Prey Pooling	32296183
Intra	TAB3	Q8N5C8	MAP3K7CL	Homo sapiens	P57077-4	Y2H Array	32296183
Intra	TAB3	Q8N5C8	MAP3K7	Homo sapiens	O43318	Anti Bait CoIP	22081109
Intra	TAB3	Q8N5C8	MAP3K7	Homo sapiens	O43318	Anti Tag CoIP	21903422
Intra	TAB3	Q8N5C8	BECN1	Homo sapiens	Q14457	Anti Tag CoIP	22081109
Intra	TAB3	Q8N5C8	BECN1	Homo sapiens	Q14457	Anti Bait CoIP	22081109

Cross: Cross-species interaction Intra: Intraspecies interaction

TAB3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82656	TAB3 Antibody (YA2401)	WB, ICC/IF	Human, Mouse

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14135	TAB3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TAB3	VGNC	VGNC:47060
Mus musculus	TAB3	MGD	MGI:1913974
Rattus norvegicus	TAB3	RGD	RGD:1594527
Bos taurus	TAB3	VGNC	VGNC:56955

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