TAB3 - TGF-beta activated kinase 1 (MAP3K7) binding protein 3 Gene

Homo sapiens

Also known as NAP1; MAP3K7IP3

Gene ID: 257397 | Gene type: protein coding

About TAB3

Cytogenetic location: Xp21.2 Genomic coordinates (GRCh38): X:30,827,442-30,889,254 (from NCBI)

This gene has 6 transcripts (splice variants), 207 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 6.3), endometrium (RPKM 5.6) and 25 other tissues.

Summary

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

TAB3 Products(4)

mRNA	Protein	Name
NM_001399870.1	NP_001386799.1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 2
NM_001399872.1	NP_001386801.1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 3
NM_001399873.1	NP_001386802.1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 4
NM_152787.5	NP_690000.3	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables K63-linked polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	15327770	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	15327770	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17158449	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	22158122	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	18079694	GOA
involved in non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	15327770	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	15327770	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	23487264	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15327770	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAB3 Protein Structure

CUE

0
200
400
600
712 a.a.

Protein Preferred Names

Protein Names

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

NF-kappa-B-activating protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14135	TAB3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TAB3	VGNC	VGNC:47060
Mus musculus	TAB3	MGD	MGI:1913974
Rattus norvegicus	TAB3	RGD	RGD:1594527
Bos taurus	TAB3	VGNC	VGNC:56955

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