Il17f - interleukin 17F Gene

Mus musculus

Also known as IL-17F

Gene ID: 257630 | Gene type: protein coding

About Il17f

Summary

Enables cytokine receptor binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in defense response to bacterium and positive regulation of gene expression. Acts upstream of or within positive regulation of cytokine production involved in inflammatory response and positive regulation of transcription by RNA polymerase II. Located in extracellular space. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis. Orthologous to human IL17F (interleukin 17F). [provided by Alliance of Genome Resources, Apr 2022]

Il17f Products(1)

mRNA	Protein	Name
NM_145856.2	NP_665855.2	interleukin-17F precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytokine receptor binding	IPI IPI: Inferred from physical interaction	17911633	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18025225	MGI
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	18025225	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	18025225	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in defense response to Gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	19144317	MGI
involved in defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	19144317	MGI
involved in positive regulation of antimicrobial peptide production	IDA IDA: Inferred from direct assay	19144317	MGI
acts upstream of or within positive regulation of cytokine production involved in inflammatory response	IDA IDA: Inferred from direct assay	16785495	MGI
acts upstream of or within positive regulation of cytokine production involved in inflammatory response	IGI IGI: Inferred from genetic interaction	16785495	MGI
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	20554964	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16982811	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16982811	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	17982105	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

interleukin-17F

Recombinant Il17f Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72584	IL-17F Protein, Mouse (HEK293, His)	Q7TNI7-1 (R29-A161)	≥95%
HY-P74831	IL-17F Protein, Mouse	Q7TNI7-1 (R21-A153)	≥95%
HY-P77707	IL-17A/F Heterodimer Protein, Mouse (HEK293, His-Avi)	Q62386 (A26-A158)&Q7TNI7 (R29-A161)	≥95%
HY-P77708	IL-17A/F Heterodimer Protein, Mouse (Biotinylated, HEK293, His-Avi)	Q62386 (A26-A158)&Q7TNI7-1 (R29-A161)	≥95%
HY-P78160	IL-17F Protein, Mouse (Biotinylated, HEK293, His-Avi)	Q7TNI7-1 (R29-A161)	≥95%
HY-P78321	IL-17F Protein, Mouse (HEK293, His-Avi)	Q7TNI7-1 (R29-A161)	≥95%
HY-P700195AF	Animal-Free IL-17F Protein, Mouse (His)	Q7TNI7-1 (R29-A161)	≥95%

Related Agents

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99280	Bimekizumab	Antagonist	95.00%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-152851	Izumerogant	Agonist	99.95%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99397	Sonelokimab	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153276	Androgen receptor-IN-5	Inhibitor	/	Unkown
HY-RS06701	IL17F Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99424	Afasevikumab	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il17f	NCBI	NCBI:112744
Macaca fascicularis	Il17f	NCBI	NCBI:102118959
Rattus norvegicus	Il17f	NCBI	NCBI:301291

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