1. Gene
  2. Nod2 - nucleotide-binding oligomerization domain containing 2 Gene

Nod2 - nucleotide-binding oligomerization domain containing 2 Gene

Mus musculus

Also known as CD; ACUG; BLAU; IBD1; Nlrc2; Card15; F830032C23Rik

Gene ID: 257632 | Gene type: protein coding

About Nod2

Chromosome 8: 89,373,943-89,415,102 forward strand.GRCm39:CM001001.3

This gene has 4 transcripts (splice variants), 167 orthologues, 22 paralogues and is associated with 52 phenotypes. Broad expression in lung adult (RPKM 1.5), spleen adult (RPKM 1.3) and 19 other tissues.

Summary

Enables muramyl dipeptide binding activity. Involved in several processes, including negative regulation of macrophage apoptotic process; positive regulation of macromolecule metabolic process; and positive regulation of prostaglandin-E synthase activity. Acts upstream of or within several processes, including positive regulation of intracellular signal transduction; regulation of gene expression; and response to bacterium. Predicted to be located in several cellular components, including Golgi apparatus; basolateral plasma membrane; and phagocytic vesicle. Predicted to be anchored component of plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Used to study inflammatory bowel disease 1. Human ortholog(s) of this gene implicated in several diseases, including Blau syndrome; autoimmune disease (multiple); gastrointestinal carcinoma; intestinal disease (multiple); and lung disease (multiple). Orthologous to human NOD2 (nucleotide binding oligomerization domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Nod2 Products(1)

mRNA Protein Name
NM_145857.2 NP_665856.2 nucleotide-binding oligomerization domain-containing protein 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables muramyl dipeptide binding IDA
IDA: Inferred from direct assay
18167348 MGI
enables muramyl dipeptide binding IMP
IMP: Inferred from mutant phenotype
25429073 MGI
enables pattern recognition receptor activity IDA
IDA: Inferred from direct assay
18261938 MGI
enables pattern recognition receptor activity IMP
IMP: Inferred from mutant phenotype
22033934 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17187069 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
18261938 MGI
acts upstream of JNK cascade IDA
IDA: Inferred from direct assay
18261938 MGI
acts upstream of MAPK cascade IMP
IMP: Inferred from mutant phenotype
15692051 MGI
acts upstream of or within activation of immune response IMP
IMP: Inferred from mutant phenotype
15692051 MGI
acts upstream of biosynthetic process of antibacterial peptides active against Gram-positive bacteria IMP
IMP: Inferred from mutant phenotype
15692051 MGI
acts upstream of or within cellular response to peptidoglycan IMP
IMP: Inferred from mutant phenotype
16949315 MGI
acts upstream of or within defense response to Gram-positive bacterium IGI
IGI: Inferred from genetic interaction
18261938 MGI
acts upstream of or within defense response to Gram-positive bacterium IMP
IMP: Inferred from mutant phenotype
15692051 MGI
involved in defense response to bacterium IMP
IMP: Inferred from mutant phenotype
15692052 MGI
acts upstream of establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
19139201 MGI
involved in host-mediated regulation of intestinal microbiota composition IMP
IMP: Inferred from mutant phenotype
21421666 MGI
acts upstream of or within immunoglobulin production involved in immunoglobulin-mediated immune response IMP
IMP: Inferred from mutant phenotype
15692051 MGI
acts upstream of or within innate immune response in mucosa IMP
IMP: Inferred from mutant phenotype
15692051 MGI
acts upstream of interleukin-12 production IDA
IDA: Inferred from direct assay
15220916 MGI
acts upstream of interleukin-12 production IMP
IMP: Inferred from mutant phenotype
14560001 MGI
acts upstream of interleukin-18 production IMP
IMP: Inferred from mutant phenotype
15220916 MGI
acts upstream of interleukin-2 production IMP
IMP: Inferred from mutant phenotype
19139201 MGI
acts upstream of interleukin-6 production IDA
IDA: Inferred from direct assay
18261938 MGI
acts upstream of interleukin-6 production IGI
IGI: Inferred from genetic interaction
18261938 MGI
acts upstream of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
15692051 MGI
involved in intestinal stem cell homeostasis IMP
IMP: Inferred from mutant phenotype
31919280 MGI
acts upstream of macrophage cytokine production IDA
IDA: Inferred from direct assay
15220916 MGI
acts upstream of macrophage cytokine production IGI
IGI: Inferred from genetic interaction
18261938 MGI
acts upstream of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
14560001 MGI
acts upstream of or within macrophage inflammatory protein-1 alpha production IMP
IMP: Inferred from mutant phenotype
19139201 MGI
acts upstream of or within negative regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
15220916 MGI
acts upstream of or within negative regulation of T cell mediated immunity IMP
IMP: Inferred from mutant phenotype
16949315 MGI
acts upstream of or within negative regulation of inflammatory response to antigenic stimulus IMP
IMP: Inferred from mutant phenotype
16949315 MGI
acts upstream of or within negative regulation of interleukin-12 production IDA
IDA: Inferred from direct assay
15220916 MGI
acts upstream of or within negative regulation of interleukin-12 production IMP
IMP: Inferred from mutant phenotype
15220916 MGI
acts upstream of or within negative regulation of interleukin-18 production IMP
IMP: Inferred from mutant phenotype
15220916 MGI
acts upstream of or within negative regulation of interleukin-2 production IMP
IMP: Inferred from mutant phenotype
19139201 MGI
involved in negative regulation of macrophage apoptotic process IDA
IDA: Inferred from direct assay
21156799 MGI
acts upstream of or within negative regulation of macrophage cytokine production IDA
IDA: Inferred from direct assay
15220916 MGI
acts upstream of or within negative regulation of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
15220916 MGI
acts upstream of or within negative regulation of toll-like receptor 2 signaling pathway IMP
IMP: Inferred from mutant phenotype
15220916 MGI
acts upstream of or within negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
19139201 MGI
acts upstream of or within negative regulation of type II interferon production IMP
IMP: Inferred from mutant phenotype
15220916 MGI
involved in nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
IDA: Inferred from direct assay
27007849 MGI
acts upstream of or within nucleotide-binding oligomerization domain containing 2 signaling pathway IMP
IMP: Inferred from mutant phenotype
23892723 MGI
involved in nucleotide-binding oligomerization domain containing 2 signaling pathway IMP
IMP: Inferred from mutant phenotype
15692052 MGI
acts upstream of peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
15692051 MGI
acts upstream of phagocytosis IMP
IMP: Inferred from mutant phenotype
19139201 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
18261938 MGI
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
21156799 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
22033934 MGI
acts upstream of or within positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
18261938 MGI
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
21156799 MGI
acts upstream of or within positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
15692051 MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
15220916 MGI
involved in positive regulation of Notch signaling pathway IDA
IDA: Inferred from direct assay
21156799 MGI
acts upstream of or within positive regulation of antibacterial peptide biosynthetic process IDA
IDA: Inferred from direct assay
18167348 MGI
involved in positive regulation of autophagy IDA
IDA: Inferred from direct assay
19898471 MGI
acts upstream of or within positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria IMP
IMP: Inferred from mutant phenotype
15692051 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
18261938 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
15692052 MGI
involved in positive regulation of dendritic cell antigen processing and presentation IMP
IMP: Inferred from mutant phenotype
20008287 MGI
involved in positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
18855982 MGI
acts upstream of or within positive regulation of humoral immune response mediated by circulating immunoglobulin IMP
IMP: Inferred from mutant phenotype
15692051 MGI
involved in positive regulation of innate immune response IDA
IDA: Inferred from direct assay
21156799 MGI
acts upstream of or within positive regulation of innate immune response IMP
IMP: Inferred from mutant phenotype
15692051 MGI
acts upstream of positive regulation of interleukin-10 production IMP
IMP: Inferred from mutant phenotype
21156799 MGI
acts upstream of or within positive regulation of interleukin-12 production IDA
IDA: Inferred from direct assay
15220916 MGI
acts upstream of or within positive regulation of interleukin-12 production IMP
IMP: Inferred from mutant phenotype
14560001 MGI
acts upstream of or within positive regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
18261938 MGI
acts upstream of or within positive regulation of interleukin-6 production IGI
IGI: Inferred from genetic interaction
18261938 MGI
acts upstream of or within positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
15692051 MGI
acts upstream of or within positive regulation of macrophage cytokine production IDA
IDA: Inferred from direct assay
15220916 MGI
acts upstream of or within positive regulation of macrophage cytokine production IGI
IGI: Inferred from genetic interaction
18261938 MGI
acts upstream of or within positive regulation of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
14560001 MGI
involved in positive regulation of mitophagy IMP
IMP: Inferred from mutant phenotype
31919280 MGI
involved in positive regulation of monocyte chemotactic protein-1 production IMP
IMP: Inferred from mutant phenotype
16203728 MGI
involved in positive regulation of nitric-oxide synthase biosynthetic process IMP
IMP: Inferred from mutant phenotype
21156799 MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
22033934 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
15692051 MGI
acts upstream of or within positive regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
19139201 MGI
involved in positive regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
15620648 MGI
acts upstream of or within positive regulation of stress-activated MAPK cascade IDA
IDA: Inferred from direct assay
18261938 MGI
acts upstream of or within positive regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
18261938 MGI
acts upstream of or within positive regulation of tumor necrosis factor production IGI
IGI: Inferred from genetic interaction
18261938 MGI
acts upstream of or within positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
15220916 MGI
acts upstream of or within positive regulation of xenophagy IMP
IMP: Inferred from mutant phenotype
22033934 MGI
involved in regulation of appetite IMP
IMP: Inferred from mutant phenotype
35420957 MGI
acts upstream of or within regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
19218085 MGI
acts upstream of or within regulation of neutrophil chemotaxis IMP
IMP: Inferred from mutant phenotype
19139201 MGI
involved in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
27007849 MGI
acts upstream of or within response to exogenous dsRNA IMP
IMP: Inferred from mutant phenotype
15692051 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
14560001 MGI
acts upstream of or within response to muramyl dipeptide IDA
IDA: Inferred from direct assay
15220916 MGI
involved in response to muramyl dipeptide IDA
IDA: Inferred from direct assay
35420957 MGI
acts upstream of or within response to muramyl dipeptide IMP
IMP: Inferred from mutant phenotype
14560001 MGI
involved in response to muramyl dipeptide IMP
IMP: Inferred from mutant phenotype
15692052 MGI
acts upstream of or within response to peptidoglycan IDA
IDA: Inferred from direct assay
15220916 MGI
acts upstream of or within response to peptidoglycan IMP
IMP: Inferred from mutant phenotype
15220916 MGI
acts upstream of stress-activated MAPK cascade IDA
IDA: Inferred from direct assay
18261938 MGI
involved in temperature homeostasis IMP
IMP: Inferred from mutant phenotype
35420957 MGI
acts upstream of toll-like receptor 2 signaling pathway IMP
IMP: Inferred from mutant phenotype
15220916 MGI
acts upstream of tumor necrosis factor production IDA
IDA: Inferred from direct assay
18261938 MGI
acts upstream of tumor necrosis factor production IGI
IGI: Inferred from genetic interaction
18261938 MGI
acts upstream of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
18261938 MGI
acts upstream of type II interferon production IMP
IMP: Inferred from mutant phenotype
15220916 MGI
acts upstream of xenophagy IMP
IMP: Inferred from mutant phenotype
22033934 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nod2 Protein Structure

DD

DD: cl14633 (6 - 86)

DD

DD: cl14633 (106 - 185)

NACHT

NACHT: pfam05729 (265 - 435)

NOD2_WH

NOD2_WH: pfam17779 (517 - 573)

NLRC4_HD2

NLRC4_HD2: cl39284 (575 - 729)

PPP1R42

PPP1R42: cl42388 (752 - 979)

LRR_RI

LRR_RI: sd00033 (767 - 788)

LRR_RI

LRR_RI: sd00033 (789 - 816)

LRR_RI

LRR_RI: sd00033 (817 - 845)

LRR_RI

LRR_RI: sd00033 (846 - 872)

LRR_RI

LRR_RI: sd00033 (873 - 900)

LRR_RI

LRR_RI: sd00033 (901 - 928)

LRR_RI

LRR_RI: sd00033 (929 - 956)

LRR_RI

LRR_RI: sd00033 (957 - 978)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1013 a.a.
Protein Preferred Names Protein Names

nucleotide-binding oligomerization domain-containing protein 2

caspase recruitment domain family, member 15

caspase recruitment domain-containing protein 15

Orthologs Information

Species Symbol Source ID
Homo sapiens Nod2 NCBI NCBI:64127