1. Gene
  2. NOD2 - nucleotide binding oligomerization domain containing 2 Gene

NOD2 - nucleotide binding oligomerization domain containing 2 Gene

Homo sapiens

Also known as CD; ACUG; BLAU; IBD1; YAOS; BLAUS; NLRC2; NOD2B; CARD15; CLR16.3; PSORAS1

Gene ID: 64127 | Gene type: protein coding

About NOD2

Cytogenetic location: 16q12.1 Genomic coordinates (GRCh38): 16:50,693,606-50,733,075 (from NCBI)

This gene has 17 transcripts (splice variants), 167 orthologues, 20 paralogues and is associated with 9 phenotypes. Broad expression in bone marrow (RPKM 3.3), appendix (RPKM 2.5) and 16 other tissues.

Summary

This gene is a member of the NOD1/Apaf-1 family and encodes a protein with two Caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular Bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

NOD2 Products(18)

mRNA Protein Name
XM_047434453.1 XP_047290409.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X2
XM_006721242.5 XP_006721305.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X1
XM_047434454.1 XP_047290410.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X2
NM_001293557.2 NP_001280486.1 nucleotide-binding oligomerization domain-containing protein 2 isoform 2
NM_022162.3 NP_071445.1 nucleotide-binding oligomerization domain-containing protein 2 isoform 1
NR_163434.1
XM_017023537.2 XP_016879026.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X3
XM_011523260.4 XP_011521562.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X6
XR_007064895.1
NM_001370466.1 NP_001357395.1 nucleotide-binding oligomerization domain-containing protein 2 isoform 2
XM_047434457.1 XP_047290413.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X8
XM_047434452.1 XP_047290408.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X2
XM_006721243.5 XP_006721306.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X5
XR_007064894.1
XM_011523261.3 XP_011521563.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X4
XM_047434456.1 XP_047290412.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X7
XM_047434455.1 XP_047290411.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X6
XM_017023536.2 XP_016879025.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables CARD domain binding IPI
IPI: Inferred from physical interaction
11087742 GOA
enables Hsp70 protein binding IPI
IPI: Inferred from physical interaction
24790089 GOA
enables Hsp90 protein binding IDA
IDA: Inferred from direct assay
24790089 GOA
enables actin binding IDA
IDA: Inferred from direct assay
24790089 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
15753091 GOA
enables muramyl dipeptide binding IDA
IDA: Inferred from direct assay
12871942 GOA
enables pattern recognition receptor activity IDA
IDA: Inferred from direct assay
12871942 GOA
enables peptidoglycan binding IDA
IDA: Inferred from direct assay
15998797 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11472070 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
15075345 GOA
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
17337451 GOA
enables ubiquitin binding IDA
IDA: Inferred from direct assay
23300079 GOA
Biological Process GO Annotation Evidence Reference Source
involved in antibacterial innate immune response IDA
IDA: Inferred from direct assay
20406817 GOA
involved in cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
27812135 GOA
involved in cellular response to muramyl dipeptide IDA
IDA: Inferred from direct assay
21887730 GOA
involved in cellular response to muramyl dipeptide IMP
IMP: Inferred from mutant phenotype
25093298 GOA
involved in defense response to bacterium IDA
IDA: Inferred from direct assay
12514169 GOA
involved in detection of bacterium IDA
IDA: Inferred from direct assay
15653568 GOA
acts upstream of or within detection of muramyl dipeptide IDA
IDA: Inferred from direct assay
12527755 GOA
involved in detection of muramyl dipeptide IDA
IDA: Inferred from direct assay
15998797 GOA
involved in innate immune response IDA
IDA: Inferred from direct assay
23806334 GOA
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
15653568 GOA
involved in maintenance of gastrointestinal epithelium IMP
IMP: Inferred from mutant phenotype
17058067 GOA
acts upstream of or within nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
IDA: Inferred from direct assay
12527755 GOA
involved in nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
IDA: Inferred from direct assay
12626759 GOA
involved in pattern recognition receptor signaling pathway IDA
IDA: Inferred from direct assay
31649195 GOA
involved in positive regulation of B cell activation IDA
IDA: Inferred from direct assay
20844241 GOA
acts upstream of or within positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
17187069 GOA
acts upstream of or within positive regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
12527755 GOA
involved in positive regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
11385577 GOA
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
16203728 GOA
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
12527755 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
11087742 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
15998797 GOA
involved in positive regulation of cytokine production involved in immune response IMP
IMP: Inferred from mutant phenotype
16260731 GOA
involved in positive regulation of cytokine production involved in inflammatory response IDA
IDA: Inferred from direct assay
24671169 GOA
involved in positive regulation of interleukin-1 beta production IDA
IDA: Inferred from direct assay
15107016 GOA
involved in positive regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
21040358 GOA
involved in positive regulation of interleukin-17 production IMP
IMP: Inferred from mutant phenotype
17919942 GOA
involved in positive regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
16414084 GOA
involved in positive regulation of interleukin-8 production IMP
IMP: Inferred from mutant phenotype
24790089 GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
25093298 GOA
involved in positive regulation of protein K63-linked ubiquitination IMP
IMP: Inferred from mutant phenotype
25891078 GOA
acts upstream of or within positive regulation of stress-activated MAPK cascade IDA
IDA: Inferred from direct assay
17187069 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21887730 GOA
acts upstream of or within positive regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
17187069 GOA
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
21040358 GOA
involved in positive regulation of type 2 immune response IMP
IMP: Inferred from mutant phenotype
21172192 GOA
involved in response to muramyl dipeptide IDA
IDA: Inferred from direct assay
12514169 GOA
involved in response to muramyl dipeptide IMP
IMP: Inferred from mutant phenotype
24790089 GOA
Cellular Component GO Annotation Evidence Reference Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
16203728 GOA
located in cell surface IDA
IDA: Inferred from direct assay
16714539 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
21887730 GOA
located in cytoskeleton IDA
IDA: Inferred from direct assay
21887730 GOA
is active in cytosol IDA
IDA: Inferred from direct assay
19701189 GOA
located in cytosol IDA
IDA: Inferred from direct assay
14570728 GOA
is active in extrinsic component of plasma membrane IDA
IDA: Inferred from direct assay
17355968 GOA
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
31649195 GOA
is active in plasma membrane IDA
IDA: Inferred from direct assay
17355968 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
15998797 GOA
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
31649195 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
21887730 GOA
located in vesicle IDA
IDA: Inferred from direct assay
15998797 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOD2 Protein Structure

CARD

CARD: Caspase recruitment domain (31 - 120)

CARD

CARD: Caspase recruitment domain (133 - 205)

NACHT

NACHT: NACHT domain (293 - 462)

LRR_6

LRR_6: Leucine Rich repeat (898 - 921)

LRR_6

LRR_6: Leucine Rich repeat (927 - 948)

LRR_6

LRR_6: Leucine Rich repeat (957 - 977)

LRR_6

LRR_6: Leucine Rich repeat (982 - 1004)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1040 a.a.
Protein Preferred Names Protein Names

nucleotide-binding oligomerization domain-containing protein 2

NLR family, CARD domain containing 2

NOD-like receptor C2

caspase recruitment domain family, member 15

caspase recruitment domain protein 15

caspase recruitment domain-containing protein 15

inflammatory bowel disease protein 1

nucleotide-binding oligomerization domain 2

nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2

NOD2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NOD2 Q9HC29 GALNT2 Homo sapiens Q10471
Anti Bait CoIP
21699783
Intra
NOD2 Q9HC29 GALNT2 Homo sapiens Q10471
Y2H
21699783
Intra
NOD2 Q9HC29 FIS1 Homo sapiens Q9Y3D6
Y2H
21699783
Intra
NOD2 Q9HC29 FIS1 Homo sapiens Q9Y3D6
Anti Bait CoIP
21699783
Intra
NOD2 Q9HC29 VIM Homo sapiens P08670
Anti Bait CoIP
22684479
Intra
NOD2 Q9HC29 VIM Homo sapiens P08670
Anti Bait CoIP
21699783
Intra
NOD2 Q9HC29 VIM Homo sapiens P08670
Anti Tag CoIP
35273242
Intra
NOD2 Q9HC29 VIM Homo sapiens P08670
Y2H
21699783
Intra
NOD2 Q9HC29 VIM Homo sapiens P08670
Anti Tag CoIP
22684479
Intra
NOD2 Q9HC29 VIM Homo sapiens P08670
Y2H
22684479
Intra
NOD2 Q9HC29 VIM Homo sapiens P08670
IF
22684479
Intra
NOD2 Q9HC29 RIPK2 Homo sapiens O43353
Anti Tag CoIP
22829933
Intra
NOD2 Q9HC29 RIPK2 Homo sapiens O43353
Anti Tag CoIP
21931826
Intra
NOD2 Q9HC29 RIPK2 Homo sapiens O43353
CoIP
11087742
Intra
NOD2 Q9HC29 NDUFA13 Homo sapiens Q9P0J0
Confocal
15753091
Intra
NOD2 Q9HC29 NDUFA13 Homo sapiens Q9P0J0
Y2H
15753091
Intra
NOD2 Q9HC29 NDUFA13 Homo sapiens Q9P0J0
Anti Tag CoIP
15753091
Intra
NOD2 Q9HC29 KAT5 Homo sapiens Q92993
Anti Bait CoIP
21699783
Intra
NOD2 Q9HC29 KAT5 Homo sapiens Q92993
Y2H
21699783
Intra
NOD2 Q9HC29 CASP1 Homo sapiens P29466
Anti Tag CoIP
18511561
Intra
NOD2 Q9HC29 TRIM27 Homo sapiens P14373
Pull Down
22829933
Intra
NOD2 Q9HC29 TRIM27 Homo sapiens P14373
Anti Tag CoIP
22829933
Intra
NOD2 Q9HC29 TRIM27 Homo sapiens P14373
Anti Bait CoIP
22829933
Intra
NOD2 Q9HC29 TRIM27 Homo sapiens P14373
IF
22829933
Intra
NOD2 Q9HC29 ERBIN Homo sapiens Q96RT1-2
Anti Tag CoIP
16203728
Intra
NOD2 Q9HC29 ERBIN Homo sapiens Q96RT1-2
Anti Bait CoIP
16203728
Intra
NOD2 Q9HC29 PPP2R5E Homo sapiens Q16537
Y2H
21699783
Intra
NOD2 Q9HC29 PPP2R5E Homo sapiens Q16537
Anti Bait CoIP
21699783
Intra
NOD2 Q9HC29 ERBIN Homo sapiens Q96RT1
Pull Down
30833792
Intra
NOD2 Q9HC29 ERBIN Homo sapiens Q96RT1
Anti Tag CoIP
16203728
Intra
NOD2 Q9HC29 ERBIN Homo sapiens Q96RT1
Confocal
16203728
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spondyloarthropathy

Spondylarthropathies

Spondarthropathy

Spondylarthrosis

Spondyloarthropathy, Susceptibility To

Spondylarthritis

Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Iritis
Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome

Pyoderma
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Familial Cold Autoinflammatory Syndrome

Familial Cold Urticaria

Fcas

Familial Polymorphous Cold Eruption

Fcu

Cold Hypersensitivity

Yao Syndrome

YAOS

Susceptibility To Yao Syndrome

Naid

Nod2-Associated Aid

Nod2-Associated Autoinflammatory Disease

Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin

Intestinal Tuberculosis

Tuberculosis Of Intestine

Tuberculosis Of Intestines

Gastroduodenal Crohn'S Disease

Upper Gi Crohn'S Disease

Cinca Syndrome

CINCA

Nomid

Cryopyrin-Associated Periodic Syndrome 3

Chronic Neurologic Cutaneous And Articular Syndrome

Multisystem Inflammatory Disease, Neonatal-Onset

Caps3

Chronic Infantile Neurological Cutaneous Articular Syndrome

Infantile-Onset Multisystem Inflammatory Disease

Iomid Syndrome

Neonatal-Onset Multisystem Inflammatory Disease

Nomid Syndrome

Prieur-Griscelli Syndrome

Neonatal Onset Multisystem Inflammatory Disease

Chronic Infantile Neurological, Cutaneous And Articular Syndrome

Iomid

Infantile Onset Multisystem Inflammatory Disease

Prieur Griscelli Syndrome

Chronic Infantile Neurological Cutaneous And Articular Syndrome

Chronic, Infantile, Neurological, Cutaneous, Articular Syndrome

Chronic Infantile Neurologic Cutaneous And Articular Syndrome

Chronic Infantile Neurological, Cutaneous, And Articular Syndrome

Cryopyrin-Associated Periodic Syndromes

Diabetes Mellitus

Diabetes

Familial Mediterranean Fever

FMF

Benign Paroxysmal Peritonitis

Periodic Disease

Periodic Fever Syndrome

Recurrent Polyserositis

Familial Paroxysmal Polyserositis

Periodic Fever

Familial Mediterranean Fever, Autosomal Recessive

Familial Mediterranean Fever, Ar

Polyserositis, Recurrent

Polyserositis, Familial Paroxysmal

Periodic Peritonitis

Mef

Reimann Periodic Disease

Siegal-Cattan-Mamou Disease

Wolff Periodic Disease

Benign Recurrent Polyserositis

Mediterranean Fever, Familial

ARFMF

Autosomal Recessive Familial Mediterranean Fever

Fever, Mediterranean, Familial, Autosomal Recessive

Hereditary Autoinflammatory Diseases

Fmf - [Familial Mediterranean Fever]

Periodic Polyserositis

Periodic Familial Polyserositis

Periodic Familial Peritonitis

Paroxysmal Polyserositis

Hereditary Amyloid Nephropathy

Familial Recurrent Polyserositis

Familial Non-Neuropathic Amyloidosis

Armenian Disease

Riemann Periodic Disease

Siegal Cattan Mamou Disease

Blau Syndrome

Arthrocutaneouveal Granulomatosis

Jabs Syndrome

BLAUS

Sarcoidosis, Early-Onset

Acug

Granulomatous Inflammatory Arthritis, Dermatitis, And Uveitis, Familial

Eos

Granulomatosis, Familial Juvenile Systemic

Granulomatosis, Familial, Blau Type

Familial Juvenile Systemic Granulomatosis

Early Onset Sarcoidosis

Synovitis Granulomatous With Uveitis And Cranial Neuropathies

Early-Onset Sarcoidosis

Familial Granulomatosis, Blau Type

Pediatric Granulomatous Arthritis

Familial Granulomatosis Blau Type

Familial Granulomatous Inflammatory Arthritis Dermatitis And Uveitis

Synovitis, Granulomatous, With Uveitis And Cranial Neuropathies

Spondyloarthropathy 1

Ankylosing Spondylitis

Spondyloarthropathy, Susceptibility To, 1

SPDA1

Marie-Strumpell Spondylitis

Bechterew Syndrome

Spa

Spondylarthritis Ankylopoietica

Reiter Syndrome

Ankylosing Spondylitis, Susceptibility To

Bekhterev Syndrome

Bekhterev'S Disease

Marie-Strumpell Disease

Axial Spondylarthritis

Bechterew Disease

Marie-Struempell Disease

Spondylitis Ankylopoietica

Spondyloarthritis

Spondyloarthritis Ankylopoietica

Spas

Ankylosing Spondylarthritis

Psoriatic Arthritis

Reactive Arthritis

Rheumatoid Spondylitis

Spondylitis Ankylosans

Spondylitis Ankylosing

Spondylitis, Ankylosing

Spondylarthropathies

Arthritis, Psoriatic

Arthritis, Reactive

Gastrointestinal Tuberculosis

Tuberculosis Of Intestines, Peritoneum And Mesenteric Glands

Tuberculosis, Gastrointestinal

Tuberculosis Of Gastrointestinal Tract

Tuberculosis Of Intestines, Peritoneum, And Mesenteric Glands

Inflammatory Bowel Disease 2

IBD2

Rectal Disease

Rectal Diseases

Rectal Disorders

Perinatal Necrotizing Enterocolitis

Necrotizing Enterocolitis

Enterocolitis Necrotizing

Enterocolitis, Necrotizing

Necrotizing Enterocolitis In Fetus Or Newborn

Perinatal Necrotising Enterocolitis

Pseudomembranous Enterocolitis In Newborn

Nec

Inflammatory Bowel Disease 24

IBD24

Leprosy 3

Leprosy

Leprosy, Susceptibility To, 3

Hansen'S Disease

Leprosy, Susceptibility To

Hansen Disease

Infection Due To Mycobacterium Leprae

LPRS3

Leprosy, Type 3

Anaesthesia Leprosy

Anaesthetic Leprosy

Maculoanaesthetic Leprosy

Macular Leprosy

Leprosy Unspecified

Intestinal Perforation

Perforation Of Intestine

Bacterial Infectious Disease

Bacterial Infections

Bacterial Infection Nos

Disease Caused By Bacteria

Bacterial Disease Or Disorder

Anorectal Stricture

Stenosis Of Rectum And Anus

Anorectal Malformations

Inflammatory Bowel Disease 7

IBD7

Salmonellosis

Salmonella Infections

Salmonella Infection

Lymphoproliferative Syndrome, X-Linked, 2

XLP2

Xiap Deficiency

X-Linked Lymphoproliferative Syndrome 2

X-Linked Lymphoproliferative Disease Due To Xiap Deficiency

Xiap-Related Lymphoproliferative Disease, X-Linked

X-Linked Lymphoproliferative Syndrome Type 2

Xiap Deficiency Syndrome

Autoimmune Disease Of Gastrointestinal Tract
Q Fever

Infection Due To Coxiella Burnetii

Quadrilateral Fever

Query Fever

Nine Mile Fever

Coxiella Burnetii Fever

Q Fever Pneumonia

Coxiellosis

Pneumonia In Q Fever

Australian Q Fever

Balkan Grippe

Skin Disease

Skin Diseases

Abnormality Of The Skin

Skin Diseases, Genetic

Genodermatosis

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

Anaerobic Meningitis
Mevalonic Aciduria

Mevalonate Kinase Deficiency

Mevalonicaciduria

Hyperimmunoglobulin D With Periodic Fever

MEVA

Complete Mevalonate Kinase Deficiency

Mva

Hyperimmunoglobulinemia D

Hyper Igd Syndrome

Periodic Fever, Dutch Type

Mkd

Aciduria, Mevalonic

Deficiency Of Mevalonate Kinase

Spondylitis
Pyoderma Gangrenosum

Phagedenic Pyoderma

Phagedena Geometric

Inflammatory Bowel Disease 6

IBD6

Arthropathy

Ankylosis Of Ankle And Foot Joint

Ankylosis Of Forearm Joint

Ankylosis Of Hand Joint

Ankylosis Of Joint Of Ankle And/Or Foot

Ankylosis Of Joint Of Forearm

Ankylosis Of Joint Of Hand

Ankylosis Of Joint Of Lower Leg

Ankylosis Of Joint Of Multiple Sites

Ankylosis Of Joint Of Pelvic Region And Thigh

Ankylosis Of Joint Of Shoulder Region

Ankylosis Of Joint Of Upper Arm

Ankylosis Of Lower Leg Joint

Ankylosis Of Multiple Joints

Ankylosis Of Upper Arm Joint

Infectious Arthropathy

Joint Ankylosis Of The Ankle And Foot

Joint Ankylosis Of The Ankle And/Or Foot

Joint Ankylosis Of The Forearm

Joint Ankylosis Of The Hand

Joint Ankylosis Of The Lower Leg

Joint Ankylosis Of The Pelvic Region And Thigh

Joint Ankylosis Of The Shoulder Region

Joint Ankylosis Of The Upper Arm

Joint Diseases

Joint Disease

Arthropathy Associated With Infection

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Uveitis
Panuveitis

Diffuse Uveitis

Total Uveitis

Inflammation Of The Whole Uveal Tract

Autoinflammatory Syndrome
Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease

Colitis
Sapho Syndrome

Acquired Hyperostosis Syndrome

Synovitis, Acne, Pustulosis Palmaris, Hyperostosis, Osteomyelitis Syndrome

Synovitis Acne Pustulosis Hyperostosis Osteitis

Synovitis, Acne, Pustlosis, Hyperostosis, And Osteomyelitis

Synovitis-Acne-Pustulosis-Hyperostosis-Osteitis Syndrome

Synovitis, Acne, Pustulosis, Hyperostosis, And Osteitis Syndrome

Pustulo-Psoriatic Hyperostotic Spondylarthritis

Sapho - [Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis] Syndrome

Intestinal Obstruction

Inspissated Milk Syndrome

Milk Curd Syndrome

Chemical Colitis
Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Acquired Hypogammaglobulinemia

Common Variable Immune Deficiency

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable

Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

Pouchitis
Ulcerative Colitis

Colitis Gravis

Left Sided Ulcerative Colitis

Left-Sided Ulcerative Colitis

Idiopathic Proctocolitis

Inflammatory Bowel Disease, Ulcerative Colitis Type

Uc

Colitis Ulcerative

Colitis, Ulcerative

Chronic Left-Sided Ulcerative Colitis

Uc - [Ulcerative Colitis]

Chronic Ulcerative Enteritis

Mucosal Proctocolitis

Ulcerative Mucosal Proctocolitis

Left Hemicolitis

Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis

PSC

Sclerosing Cholangitis

Cholangitis, Sclerosing

Cholangitis Primary Sclerosing

Psc - [Primary Sclerosing Cholangitis]

Chorioretinitis

Retinochoroiditis

Dermatitis

Eczema

Skin Inflammation

Inflammatory Dermatosis

Ileocolitis

Iieocolitis

Psoriasis
Melioidosis

Melioidosis, Susceptibility To

Acute And Fulminating Melioidosis

Nightcliff Gardener'S Disease

Pseudoglanders

Subacute And Chronic Melioidosis

Burkholderia Pseudomallei Infection

Whitmore Disease

Whitmore'S Disease

B Pseudomallei Infection

Epizootic Lymphangitis

Infection Due To Burkholderia Pseudomallei

Infection Due To Burkholderia Pseudomallei Nos

Infection Due To Malleomyces Pseudomallei

Infection Due To Pseudomonas Pseudomallei

Infection Due To Pseudomonas Pseudomallei Nos

Infection Due To Whitmore Bacillus

Stanton Disease

Disease By Infectious Agent

Infectious Disease

Infectious Diseases

Aggressive Periodontitis

Juvenile Periodontitis

Periodontitis, Juvenile

Prepubertal Periodontitis

Hypersensitivity Reaction Type Iv Disease

Immunoproliferative Disorders

Immunoproliferative Disease

Inflammatory Bowel Disease 18

IBD18

Ileitis

Crohn'S Ileitis

Uveal Disease

Uveal Diseases

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Hidradenitis Suppurativa

Acne Inversa

Suppurative Hidradenitis

Acne Inversa, Familial

Apocrinitis

Hidradenitides, Suppurative

Hidradenitis, Suppurative

Suppurative Hidradenitides

Inverse Acne

Inflammatory Bowel Disease 9

IBD9

Erythema Nodosum
Muckle-Wells Syndrome

MWS

Urticaria-Deafness-Amyloidosis Syndrome

Uda Syndrome

Neutrophilic Urticaria

Urticaria, Deafness And Amyloidosis

Cryopyrin-Associated Periodic Syndrome 2

Caps2

Muckle Wells Syndrome

Urticaria-Deafness-Amyloidosis

Cryopyrin-Associated Periodic Syndromes

Granulomatous Dermatitis
Inflammatory Bowel Disease 1

Inflammatory Bowel Disease 1

IBD1

Crohn Disease-Associated Growth Failure

Crohn Disease

Regional Enteritis

Ulcerative Colitis

Crohn Disease-Associated Growth Failure, Susceptibility To

Inflammatory Bowel Disease 1, Crohn Disease

Bowel Disease, Inflammatory, Type 1

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Colonic Disease

Colonic Diseases

Colon Disorder

Hidradenitis

Hydradenitis

Osteomyelitis
Tendinitis

Tendinopathy

Periodic Fever, Familial, Autosomal Dominant

Familial Hibernian Fever

Tumor Necrosis Factor Receptor-Associated Periodic Syndrome

Traps

FPF

Tnf Receptor-Associated Periodic Fever Syndrome

Hibernian Fever, Familial

Fhf

Tnf Receptor-Associated Periodic Syndrome

Autosomal Dominant Familial Periodic Fever

Periodic Fever, Familial

Tnf Receptor 1-Associated Periodic Syndrome

Tumor Necrosis Factor Receptor 1 Associated Periodic Syndrome

Familial Periodic Fever

Traps Syndrome

Tnf Receptor Associated Periodic Syndrome

Caledonian Fever

Fever, Periodic, Familial

Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome

Melkersson-Rosenthal Syndrome

Melkersson Syndrome

Mros

Mrs

Cheilitis Granulomatosa Of Mescher-Melkersson-Rosenthal

Melkersson'S Syndrome

Cheilitis Granulomatosa

Granulomatous Cheilitis

Primary Bacterial Infectious Disease
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Psoriatic Arthritis

Psoriatic Arthritis, Susceptibility To

Psoriatic Arthropathy

Arthropathic Psoriasis

Arthritis, Psoriatic

Arthritis Psoriatica

PSORAS

Arthritic Psoriasis

Psoriasis Arthropathica

Arthritis Psoriatic

Arthritis, Psoriatic, Susceptibility To

Mycobacterium Tuberculosis 1

Tuberculosis

Tuberculosis, Susceptibility To

Tuberculoma

Mycobacterium Tuberculosis, Susceptibility To, 1

Mtbs1

TB

Mastitis

Breast Inflammation

Inflammatory Breast Disease

Inflammatory Disease Of Breast

Inflammation Of Non-Human Mammary Gland

Inflammatory Disorder Of Breast

Mastitis Nos

Acute Mastitis Nos

Acute Nonpuerperal Mastitis

Nonpuerperal Mastitis Nos

Subacute Mastitis Nos

Abdominal Tuberculosis
Autoinflammation, Panniculitis, And Dermatosis Syndrome

Otulipenia

Otulin-Related Autoinflammatory Syndrome

AIPDS

Oras

Infantile-Onset Periodic Fever-Panniculitis-Dermatosis Syndrome

Autoinflammation, Panniculitis And Dermatosis Syndrome

Otulin Deficiency

Inflammatory Bowel Disease 5

IBD5

Peritonitis

Retractile Mesenteritis

Sclerosing Mesenteritis

Acute Generalized Peritonitis

Primary Bacterial Peritonitis

Idiopathic Sclerosing Mesenteritis

Mesenteric Panniculitis

Peritoneal Retractile Mesenteritis

Liposclerotic Mesenteritis

Mesenteric Fibromatosis

Mesenteric Lipodystrophy

Mesenteric Lipogranuloma

Fibromatosis, Abdominal

Peritoneum Inflammation

Peritonitis Of Undetermined Cause

Peritonitis Of Unspecified Cause

Pelviperitonitis

Pelvic Peritonitis, Nos

Generalised Peritonitis Nos

Abdominal Peritonitis

Acute Idiopathic Peritonitis

Acute Lesser Sac Peritonitis

Acute Peritoneal Inflammation

Diffuse Peritonitis

Peritoneal Inflammation

Acute Primary Peritonitis

Pneumococcal Peritonitis

Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo

Inflammatory Bowel Disease 3

IBD3

Aspergillosis

Aspergillosis, Susceptibility To

Infection Due To Aspergillus

Aspergilloma

Aspergillus Nodule

Simple Aspergilloma

Aspergillus

Aspergillus Flavus Infection

Aspergillus Fumigatus Infection

Aspergillus Infection

Infection By Aspergillus Fumigatus

Intracavitary Aspergillus Fungus Ball

Aspergillus Terreus

Lymphadenitis

Acute Lymphadenitis

Chronic Lymphadenitis

Chronic Adenitis

Acute Adenitis

Adenitis

Inflammation Of Lymph Node

Adenitis Nos

Inflammation Of Gland

Lymphatic Gland Inflammation

Lymph Gland Inflammation

Polyadenitis

Chronic Adenitis Of Any Lymph Node Except Mesenteric

Chronic Lymphadenitis Except Mesenteric

Chronic Non-Specific Lymphadenitis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Tenosynovitis

Inflammation Of Tendon Sheath

Synovitis Or Tenosynovitis

Chronic Recurrent Multifocal Osteomyelitis

Chronic Multifocal Osteomyelitis

CRMO

Cmo

Cno/Crmo

Chronic Nonbacterial Osteomyelitis/Chronic Recurrent Multifocal Osteomyelitis

Osteomyelitis, Chronic Multifocal

Multifocal Osteomyelitis, Chronic

Chronic Osteomyelitis

Chronic Multifocal Osteomyelitis, Unspecified Site

Crmo - [Chronic Multifocal Osteomyelitis]

Chronic Osteomyelitis With Draining Sinus, Unspecified Site

Bone Fistula With Chronic Osteomyelitis

Sarcoidosis 1

Sarcoidosis

Boeck Sarcoid

Besnier-Boeck-Schaumann Disease

SS1

Sarcoidosis, Susceptibility To, 1

Lymphogranulomatosis

Hodgkin Disease

Boeck'S Disease

Boeck'S Sarcoid

Schaumann'S Disease Or Syndrome

Hutchinson-Boeck Disease Or Syndrome

Behcet Syndrome

Behcet Disease

Behcet'S Syndrome

Behcet'S Disease

Behçet Disease

Bd

Adamantiades-Behcet Disease

Triple Symptom Complex

Behet'S Syndrome

Bd Syndrome

Behçet Syndrome

Behçet'S Disease

Behçet'S Syndrome

Behcet Triple Symptom Complex

Malignant Aphthosis

Old Silk Route Disease

Adamantiades-Behçet Disease

Cholangitis

Acute Cholangiolitis

Ascending Cholangitis

Cholangiolitis

Cholangitis Nos

Chronic Cholangiolitis

Hepatic Duct Inflammation

Acute Cholangitis

Bile Duct Inflammation

Sigmoid Disease

Sigmoid Diseases

Toxoplasmosis

Disseminated Toxoplasmosis

Multisystemic Disseminated Toxoplasmosis

Acquired Toxoplasmosis

Toxoplasmosis Disease Or Disorder

Infection By Toxoplasma Gondii

Toxoplasmal

Toxoplasma

Crohn'S Disease

Crohn Disease

Pediatric Crohn'S Disease

Regional Enteritis

Crohn'S Disease Of Large Bowel

Enteritis, Granulomatous

Crohn'S Disease Of Colon

Granulomatous Colitis

Colitis, Granulomatous

Crohn'S Enteritis

Enteritis, Regional

Enteritis

Ileitis

Adenoviral Enteritis

Acute Gastroenteropathy Due To Norwalk Agent

Viral Gastroenteritis Due To Norwalk Agent

Winter Vomiting

Epidemic Winter Vomiting Disease

Small Round Structured Virus Enteritis

Epidemic Vomiting Syndrome

Epidemic Vomiting

Epidemic Nausea

Epidemic Viral Gastroenteritis Due To Norwalk Virus

Noroviral Enteritis

Crohn Disease Nos

Crohns

Cd - [Crohn'S Disease]

Regional Enteritis Of Bowel

Crohn'S Regional Enteritis

Cobble-Stone Appearance Of Intestine

Intestinal Ulcer And Erosion Due To Crohn Disease

Granulomatous Enteritis

Crohn'S Colitis

Crohn Disease

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus NOD2 VGNC VGNC:67682
Macaca mulatta NOD2 VGNC VGNC:75297
Mus musculus NOD2 MGD MGI:2429397
Canis familiaris NOD2 VGNC VGNC:43878
Bos taurus NOD2 VGNC VGNC:32151
Rattus norvegicus NOD2 RGD RGD:1306368
Others NOD2 NCBI