NOD2 - nucleotide binding oligomerization domain containing 2 Gene

Homo sapiens

Also known as CD; ACUG; BLAU; IBD1; YAOS; BLAUS; NLRC2; NOD2B; CARD15; CLR16.3; PSORAS1

Gene ID: 64127 | Gene type: protein coding

About NOD2

Cytogenetic location: 16q12.1 Genomic coordinates (GRCh38): 16:50,693,606-50,733,075 (from NCBI)

This gene has 17 transcripts (splice variants), 167 orthologues, 20 paralogues and is associated with 9 phenotypes. Broad expression in bone marrow (RPKM 3.3), appendix (RPKM 2.5) and 16 other tissues.

Summary

This gene is a member of the NOD1/Apaf-1 family and encodes a protein with two Caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular Bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

NOD2 Products(18)

mRNA	Protein	Name
XM_047434453.1	XP_047290409.1	nucleotide-binding oligomerization domain-containing protein 2 isoform X2
XM_006721242.5	XP_006721305.1	nucleotide-binding oligomerization domain-containing protein 2 isoform X1
XM_047434454.1	XP_047290410.1	nucleotide-binding oligomerization domain-containing protein 2 isoform X2
NM_001293557.2	NP_001280486.1	nucleotide-binding oligomerization domain-containing protein 2 isoform 2
NM_022162.3	NP_071445.1	nucleotide-binding oligomerization domain-containing protein 2 isoform 1
NR_163434.1
XM_017023537.2	XP_016879026.1	nucleotide-binding oligomerization domain-containing protein 2 isoform X3
XM_011523260.4	XP_011521562.1	nucleotide-binding oligomerization domain-containing protein 2 isoform X6
XR_007064895.1
NM_001370466.1	NP_001357395.1	nucleotide-binding oligomerization domain-containing protein 2 isoform 2
XM_047434457.1	XP_047290413.1	nucleotide-binding oligomerization domain-containing protein 2 isoform X8
XM_047434452.1	XP_047290408.1	nucleotide-binding oligomerization domain-containing protein 2 isoform X2
XM_006721243.5	XP_006721306.1	nucleotide-binding oligomerization domain-containing protein 2 isoform X5
XR_007064894.1
XM_011523261.3	XP_011521563.1	nucleotide-binding oligomerization domain-containing protein 2 isoform X4
XM_047434456.1	XP_047290412.1	nucleotide-binding oligomerization domain-containing protein 2 isoform X7
XM_047434455.1	XP_047290411.1	nucleotide-binding oligomerization domain-containing protein 2 isoform X6
XM_017023536.2	XP_016879025.1	nucleotide-binding oligomerization domain-containing protein 2 isoform X3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables CARD domain binding	IPI IPI: Inferred from physical interaction	11087742	GOA
enables Hsp70 protein binding	IPI IPI: Inferred from physical interaction	24790089	GOA
enables Hsp90 protein binding	IDA IDA: Inferred from direct assay	24790089	GOA
enables actin binding	IDA IDA: Inferred from direct assay	24790089	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	15753091	GOA
enables muramyl dipeptide binding	IDA IDA: Inferred from direct assay	12871942	GOA
enables pattern recognition receptor activity	IDA IDA: Inferred from direct assay	12871942	GOA
enables peptidoglycan binding	IDA IDA: Inferred from direct assay	15998797	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11472070	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	15075345	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	17337451	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	23300079	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antibacterial innate immune response	IDA IDA: Inferred from direct assay	20406817	GOA
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	27812135	GOA
involved in cellular response to muramyl dipeptide	IDA IDA: Inferred from direct assay	21887730	GOA
involved in cellular response to muramyl dipeptide	IMP IMP: Inferred from mutant phenotype	25093298	GOA
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	12514169	GOA
involved in detection of bacterium	IDA IDA: Inferred from direct assay	15653568	GOA
acts upstream of or within detection of muramyl dipeptide	IDA IDA: Inferred from direct assay	12527755	GOA
involved in detection of muramyl dipeptide	IDA IDA: Inferred from direct assay	15998797	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	23806334	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	15653568	GOA
involved in maintenance of gastrointestinal epithelium	IMP IMP: Inferred from mutant phenotype	17058067	GOA
acts upstream of or within nucleotide-binding oligomerization domain containing 2 signaling pathway	IDA IDA: Inferred from direct assay	12527755	GOA
involved in nucleotide-binding oligomerization domain containing 2 signaling pathway	IDA IDA: Inferred from direct assay	12626759	GOA
involved in pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	31649195	GOA
involved in positive regulation of B cell activation	IDA IDA: Inferred from direct assay	20844241	GOA
acts upstream of or within positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	17187069	GOA
acts upstream of or within positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	12527755	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	11385577	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	16203728	GOA
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	12527755	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	11087742	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	15998797	GOA
involved in positive regulation of cytokine production involved in immune response	IMP IMP: Inferred from mutant phenotype	16260731	GOA
involved in positive regulation of cytokine production involved in inflammatory response	IDA IDA: Inferred from direct assay	24671169	GOA
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	15107016	GOA
involved in positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	21040358	GOA
involved in positive regulation of interleukin-17 production	IMP IMP: Inferred from mutant phenotype	17919942	GOA
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	16414084	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	24790089	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	25093298	GOA
involved in positive regulation of protein K63-linked ubiquitination	IMP IMP: Inferred from mutant phenotype	25891078	GOA
acts upstream of or within positive regulation of stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	17187069	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21887730	GOA
acts upstream of or within positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	17187069	GOA
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	21040358	GOA
involved in positive regulation of type 2 immune response	IMP IMP: Inferred from mutant phenotype	21172192	GOA
involved in response to muramyl dipeptide	IDA IDA: Inferred from direct assay	12514169	GOA
involved in response to muramyl dipeptide	IMP IMP: Inferred from mutant phenotype	24790089	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	16203728	GOA
located in cell surface	IDA IDA: Inferred from direct assay	16714539	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21887730	GOA
located in cytoskeleton	IDA IDA: Inferred from direct assay	21887730	GOA
is active in cytosol	IDA IDA: Inferred from direct assay	19701189	GOA
located in cytosol	IDA IDA: Inferred from direct assay	14570728	GOA
is active in extrinsic component of plasma membrane	IDA IDA: Inferred from direct assay	17355968	GOA
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	31649195	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	17355968	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15998797	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	31649195	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	21887730	GOA
located in vesicle	IDA IDA: Inferred from direct assay	15998797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOD2 Protein Structure

CARD

NACHT

LRR_6

0
200
400
600
800
1040 a.a.

Protein Preferred Names

Protein Names

nucleotide-binding oligomerization domain-containing protein 2

NLR family, CARD domain containing 2	NOD-like receptor C2
caspase recruitment domain family, member 15	caspase recruitment domain protein 15
caspase recruitment domain-containing protein 15	inflammatory bowel disease protein 1
nucleotide-binding oligomerization domain 2	nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2

Related Diseases

Diseases

Alias

Spondyloarthropathy

Spondylarthropathies	Spondarthropathy
Spondylarthrosis	Spondyloarthropathy, Susceptibility To
Spondylarthritis

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Iritis

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Pyoderma

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Familial Cold Autoinflammatory Syndrome

Familial Cold Urticaria	Fcas
Familial Polymorphous Cold Eruption	Fcu
Cold Hypersensitivity

Yao Syndrome

YAOS	Susceptibility To Yao Syndrome
Naid	Nod2-Associated Aid
Nod2-Associated Autoinflammatory Disease

Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin

Intestinal Tuberculosis

Tuberculosis Of Intestine

Tuberculosis Of Intestines

Gastroduodenal Crohn'S Disease

Upper Gi Crohn'S Disease

Cinca Syndrome

CINCA	Nomid
Cryopyrin-Associated Periodic Syndrome 3	Chronic Neurologic Cutaneous And Articular Syndrome
Multisystem Inflammatory Disease, Neonatal-Onset	Caps3
Chronic Infantile Neurological Cutaneous Articular Syndrome	Infantile-Onset Multisystem Inflammatory Disease
Iomid Syndrome	Neonatal-Onset Multisystem Inflammatory Disease
Nomid Syndrome	Prieur-Griscelli Syndrome
Neonatal Onset Multisystem Inflammatory Disease	Chronic Infantile Neurological, Cutaneous And Articular Syndrome
Iomid	Infantile Onset Multisystem Inflammatory Disease
Prieur Griscelli Syndrome	Chronic Infantile Neurological Cutaneous And Articular Syndrome
Chronic, Infantile, Neurological, Cutaneous, Articular Syndrome	Chronic Infantile Neurologic Cutaneous And Articular Syndrome
Chronic Infantile Neurological, Cutaneous, And Articular Syndrome	Cryopyrin-Associated Periodic Syndromes

Diabetes Mellitus

Diabetes

Familial Mediterranean Fever

FMF	Benign Paroxysmal Peritonitis
Periodic Disease	Periodic Fever Syndrome
Recurrent Polyserositis	Familial Paroxysmal Polyserositis
Periodic Fever	Familial Mediterranean Fever, Autosomal Recessive
Familial Mediterranean Fever, Ar	Polyserositis, Recurrent
Polyserositis, Familial Paroxysmal	Periodic Peritonitis
Mef	Reimann Periodic Disease
Siegal-Cattan-Mamou Disease	Wolff Periodic Disease
Benign Recurrent Polyserositis	Mediterranean Fever, Familial
ARFMF	Autosomal Recessive Familial Mediterranean Fever
Fever, Mediterranean, Familial, Autosomal Recessive	Hereditary Autoinflammatory Diseases
Fmf - [Familial Mediterranean Fever]	Periodic Polyserositis
Periodic Familial Polyserositis	Periodic Familial Peritonitis
Paroxysmal Polyserositis	Hereditary Amyloid Nephropathy
Familial Recurrent Polyserositis	Familial Non-Neuropathic Amyloidosis
Armenian Disease	Riemann Periodic Disease
Siegal Cattan Mamou Disease

Blau Syndrome

Arthrocutaneouveal Granulomatosis	Jabs Syndrome
BLAUS	Sarcoidosis, Early-Onset
Acug	Granulomatous Inflammatory Arthritis, Dermatitis, And Uveitis, Familial
Eos	Granulomatosis, Familial Juvenile Systemic
Granulomatosis, Familial, Blau Type	Familial Juvenile Systemic Granulomatosis
Early Onset Sarcoidosis	Synovitis Granulomatous With Uveitis And Cranial Neuropathies
Early-Onset Sarcoidosis	Familial Granulomatosis, Blau Type
Pediatric Granulomatous Arthritis	Familial Granulomatosis Blau Type
Familial Granulomatous Inflammatory Arthritis Dermatitis And Uveitis	Synovitis, Granulomatous, With Uveitis And Cranial Neuropathies

Spondyloarthropathy 1

Ankylosing Spondylitis	Spondyloarthropathy, Susceptibility To, 1
SPDA1	Marie-Strumpell Spondylitis
Bechterew Syndrome	Spa
Spondylarthritis Ankylopoietica	Reiter Syndrome
Ankylosing Spondylitis, Susceptibility To	Bekhterev Syndrome
Bekhterev'S Disease	Marie-Strumpell Disease
Axial Spondylarthritis	Bechterew Disease
Marie-Struempell Disease	Spondylitis Ankylopoietica
Spondyloarthritis	Spondyloarthritis Ankylopoietica
Spas	Ankylosing Spondylarthritis
Psoriatic Arthritis	Reactive Arthritis
Rheumatoid Spondylitis	Spondylitis Ankylosans
Spondylitis Ankylosing	Spondylitis, Ankylosing
Spondylarthropathies	Arthritis, Psoriatic
Arthritis, Reactive

Gastrointestinal Tuberculosis

Tuberculosis Of Intestines, Peritoneum And Mesenteric Glands	Tuberculosis, Gastrointestinal
Tuberculosis Of Gastrointestinal Tract	Tuberculosis Of Intestines, Peritoneum, And Mesenteric Glands

Inflammatory Bowel Disease 2

IBD2

Rectal Disease

Rectal Diseases

Rectal Disorders

Perinatal Necrotizing Enterocolitis

Necrotizing Enterocolitis	Enterocolitis Necrotizing
Enterocolitis, Necrotizing	Necrotizing Enterocolitis In Fetus Or Newborn
Perinatal Necrotising Enterocolitis	Pseudomembranous Enterocolitis In Newborn
Nec

Inflammatory Bowel Disease 24

IBD24

Leprosy 3

Leprosy	Leprosy, Susceptibility To, 3
Hansen'S Disease	Leprosy, Susceptibility To
Hansen Disease	Infection Due To Mycobacterium Leprae
LPRS3	Leprosy, Type 3
Anaesthesia Leprosy	Anaesthetic Leprosy
Maculoanaesthetic Leprosy	Macular Leprosy
Leprosy Unspecified

Intestinal Perforation

Perforation Of Intestine

Bacterial Infectious Disease

Bacterial Infections	Bacterial Infection Nos
Disease Caused By Bacteria	Bacterial Disease Or Disorder

Anorectal Stricture

Stenosis Of Rectum And Anus

Anorectal Malformations

Inflammatory Bowel Disease 7

IBD7

Salmonellosis

Salmonella Infections

Salmonella Infection

Lymphoproliferative Syndrome, X-Linked, 2

XLP2	Xiap Deficiency
X-Linked Lymphoproliferative Syndrome 2	X-Linked Lymphoproliferative Disease Due To Xiap Deficiency
Xiap-Related Lymphoproliferative Disease, X-Linked	X-Linked Lymphoproliferative Syndrome Type 2
Xiap Deficiency Syndrome

Autoimmune Disease Of Gastrointestinal Tract

Q Fever

Infection Due To Coxiella Burnetii	Quadrilateral Fever
Query Fever	Nine Mile Fever
Coxiella Burnetii Fever	Q Fever Pneumonia
Coxiellosis	Pneumonia In Q Fever
Australian Q Fever	Balkan Grippe

Skin Disease

Skin Diseases	Abnormality Of The Skin
Skin Diseases, Genetic	Genodermatosis
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Anaerobic Meningitis

Mevalonic Aciduria

Mevalonate Kinase Deficiency	Mevalonicaciduria
Hyperimmunoglobulin D With Periodic Fever	MEVA
Complete Mevalonate Kinase Deficiency	Mva
Hyperimmunoglobulinemia D	Hyper Igd Syndrome
Periodic Fever, Dutch Type	Mkd
Aciduria, Mevalonic	Deficiency Of Mevalonate Kinase

Spondylitis

Pyoderma Gangrenosum

Phagedenic Pyoderma

Phagedena Geometric

Inflammatory Bowel Disease 6

IBD6

Arthropathy

Ankylosis Of Ankle And Foot Joint	Ankylosis Of Forearm Joint
Ankylosis Of Hand Joint	Ankylosis Of Joint Of Ankle And/Or Foot
Ankylosis Of Joint Of Forearm	Ankylosis Of Joint Of Hand
Ankylosis Of Joint Of Lower Leg	Ankylosis Of Joint Of Multiple Sites
Ankylosis Of Joint Of Pelvic Region And Thigh	Ankylosis Of Joint Of Shoulder Region
Ankylosis Of Joint Of Upper Arm	Ankylosis Of Lower Leg Joint
Ankylosis Of Multiple Joints	Ankylosis Of Upper Arm Joint
Infectious Arthropathy	Joint Ankylosis Of The Ankle And Foot
Joint Ankylosis Of The Ankle And/Or Foot	Joint Ankylosis Of The Forearm
Joint Ankylosis Of The Hand	Joint Ankylosis Of The Lower Leg
Joint Ankylosis Of The Pelvic Region And Thigh	Joint Ankylosis Of The Shoulder Region
Joint Ankylosis Of The Upper Arm	Joint Diseases
Joint Disease	Arthropathy Associated With Infection

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Uveitis

Panuveitis

Diffuse Uveitis	Total Uveitis
Inflammation Of The Whole Uveal Tract

Autoinflammatory Syndrome

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Colitis

Sapho Syndrome

Acquired Hyperostosis Syndrome	Synovitis, Acne, Pustulosis Palmaris, Hyperostosis, Osteomyelitis Syndrome
Synovitis Acne Pustulosis Hyperostosis Osteitis	Synovitis, Acne, Pustlosis, Hyperostosis, And Osteomyelitis
Synovitis-Acne-Pustulosis-Hyperostosis-Osteitis Syndrome	Synovitis, Acne, Pustulosis, Hyperostosis, And Osteitis Syndrome
Pustulo-Psoriatic Hyperostotic Spondylarthritis	Sapho - [Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis] Syndrome

Intestinal Obstruction

Inspissated Milk Syndrome

Milk Curd Syndrome

Chemical Colitis

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Acquired Hypogammaglobulinemia	Common Variable Immune Deficiency
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Pouchitis

Ulcerative Colitis

Colitis Gravis	Left Sided Ulcerative Colitis
Left-Sided Ulcerative Colitis	Idiopathic Proctocolitis
Inflammatory Bowel Disease, Ulcerative Colitis Type	Uc
Colitis Ulcerative	Colitis, Ulcerative
Chronic Left-Sided Ulcerative Colitis	Uc - [Ulcerative Colitis]
Chronic Ulcerative Enteritis	Mucosal Proctocolitis
Ulcerative Mucosal Proctocolitis	Left Hemicolitis

Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis	PSC
Sclerosing Cholangitis	Cholangitis, Sclerosing
Cholangitis Primary Sclerosing	Psc - [Primary Sclerosing Cholangitis]

Chorioretinitis

Retinochoroiditis

Dermatitis

Eczema	Skin Inflammation
Inflammatory Dermatosis

Ileocolitis

Iieocolitis

Psoriasis

Melioidosis

Melioidosis, Susceptibility To	Acute And Fulminating Melioidosis
Nightcliff Gardener'S Disease	Pseudoglanders
Subacute And Chronic Melioidosis	Burkholderia Pseudomallei Infection
Whitmore Disease	Whitmore'S Disease
B Pseudomallei Infection	Epizootic Lymphangitis
Infection Due To Burkholderia Pseudomallei	Infection Due To Burkholderia Pseudomallei Nos
Infection Due To Malleomyces Pseudomallei	Infection Due To Pseudomonas Pseudomallei
Infection Due To Pseudomonas Pseudomallei Nos	Infection Due To Whitmore Bacillus
Stanton Disease

Disease By Infectious Agent

Infectious Disease

Infectious Diseases

Aggressive Periodontitis

Juvenile Periodontitis	Periodontitis, Juvenile
Prepubertal Periodontitis

Hypersensitivity Reaction Type Iv Disease

Immunoproliferative Disorders

Immunoproliferative Disease

Inflammatory Bowel Disease 18

IBD18

Ileitis

Crohn'S Ileitis

Uveal Disease

Uveal Diseases

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Hidradenitis Suppurativa

Acne Inversa	Suppurative Hidradenitis
Acne Inversa, Familial	Apocrinitis
Hidradenitides, Suppurative	Hidradenitis, Suppurative
Suppurative Hidradenitides	Inverse Acne

Inflammatory Bowel Disease 9

IBD9

Erythema Nodosum

Muckle-Wells Syndrome

MWS	Urticaria-Deafness-Amyloidosis Syndrome
Uda Syndrome	Neutrophilic Urticaria
Urticaria, Deafness And Amyloidosis	Cryopyrin-Associated Periodic Syndrome 2
Caps2	Muckle Wells Syndrome
Urticaria-Deafness-Amyloidosis	Cryopyrin-Associated Periodic Syndromes

Granulomatous Dermatitis

Inflammatory Bowel Disease 1

Inflammatory Bowel Disease 1	IBD1
Crohn Disease-Associated Growth Failure	Crohn Disease
Regional Enteritis	Ulcerative Colitis
Crohn Disease-Associated Growth Failure, Susceptibility To	Inflammatory Bowel Disease 1, Crohn Disease
Bowel Disease, Inflammatory, Type 1

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Protection Against	Lung Cancer, Susceptibility To
Adenocarcinoma Of Lung, Somatic	Nonsmall Cell Lung Cancer
Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Colonic Disease

Colonic Diseases

Colon Disorder

Hidradenitis

Hydradenitis

Osteomyelitis

Tendinitis

Tendinopathy

Periodic Fever, Familial, Autosomal Dominant

Familial Hibernian Fever	Tumor Necrosis Factor Receptor-Associated Periodic Syndrome
Traps	FPF
Tnf Receptor-Associated Periodic Fever Syndrome	Hibernian Fever, Familial
Fhf	Tnf Receptor-Associated Periodic Syndrome
Autosomal Dominant Familial Periodic Fever	Periodic Fever, Familial
Tnf Receptor 1-Associated Periodic Syndrome	Tumor Necrosis Factor Receptor 1 Associated Periodic Syndrome
Familial Periodic Fever	Traps Syndrome
Tnf Receptor Associated Periodic Syndrome	Caledonian Fever
Fever, Periodic, Familial	Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome

Melkersson-Rosenthal Syndrome

Melkersson Syndrome	Mros
Mrs	Cheilitis Granulomatosa Of Mescher-Melkersson-Rosenthal
Melkersson'S Syndrome	Cheilitis Granulomatosa
Granulomatous Cheilitis

Primary Bacterial Infectious Disease

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Psoriatic Arthritis

Psoriatic Arthritis, Susceptibility To	Psoriatic Arthropathy
Arthropathic Psoriasis	Arthritis, Psoriatic
Arthritis Psoriatica	PSORAS
Arthritic Psoriasis	Psoriasis Arthropathica
Arthritis Psoriatic	Arthritis, Psoriatic, Susceptibility To

Mycobacterium Tuberculosis 1

Tuberculosis	Tuberculosis, Susceptibility To
Tuberculoma	Mycobacterium Tuberculosis, Susceptibility To, 1
Mtbs1	TB

Mastitis

Breast Inflammation	Inflammatory Breast Disease
Inflammatory Disease Of Breast	Inflammation Of Non-Human Mammary Gland
Inflammatory Disorder Of Breast	Mastitis Nos
Acute Mastitis Nos	Acute Nonpuerperal Mastitis
Nonpuerperal Mastitis Nos	Subacute Mastitis Nos

Abdominal Tuberculosis

Autoinflammation, Panniculitis, And Dermatosis Syndrome

Otulipenia	Otulin-Related Autoinflammatory Syndrome
AIPDS	Oras
Infantile-Onset Periodic Fever-Panniculitis-Dermatosis Syndrome	Autoinflammation, Panniculitis And Dermatosis Syndrome
Otulin Deficiency

Inflammatory Bowel Disease 5

IBD5

Peritonitis

Retractile Mesenteritis	Sclerosing Mesenteritis
Acute Generalized Peritonitis	Primary Bacterial Peritonitis
Idiopathic Sclerosing Mesenteritis	Mesenteric Panniculitis
Peritoneal Retractile Mesenteritis	Liposclerotic Mesenteritis
Mesenteric Fibromatosis	Mesenteric Lipodystrophy
Mesenteric Lipogranuloma	Fibromatosis, Abdominal
Peritoneum Inflammation	Peritonitis Of Undetermined Cause
Peritonitis Of Unspecified Cause	Pelviperitonitis
Pelvic Peritonitis, Nos	Generalised Peritonitis Nos
Abdominal Peritonitis	Acute Idiopathic Peritonitis
Acute Lesser Sac Peritonitis	Acute Peritoneal Inflammation
Diffuse Peritonitis	Peritoneal Inflammation
Acute Primary Peritonitis	Pneumococcal Peritonitis

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Inflammatory Bowel Disease 3

IBD3

Aspergillosis

Aspergillosis, Susceptibility To	Infection Due To Aspergillus
Aspergilloma	Aspergillus Nodule
Simple Aspergilloma	Aspergillus
Aspergillus Flavus Infection	Aspergillus Fumigatus Infection
Aspergillus Infection	Infection By Aspergillus Fumigatus
Intracavitary Aspergillus Fungus Ball	Aspergillus Terreus

Lymphadenitis

Acute Lymphadenitis	Chronic Lymphadenitis
Chronic Adenitis	Acute Adenitis
Adenitis	Inflammation Of Lymph Node
Adenitis Nos	Inflammation Of Gland
Lymphatic Gland Inflammation	Lymph Gland Inflammation
Polyadenitis	Chronic Adenitis Of Any Lymph Node Except Mesenteric
Chronic Lymphadenitis Except Mesenteric	Chronic Non-Specific Lymphadenitis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Tenosynovitis

Inflammation Of Tendon Sheath

Synovitis Or Tenosynovitis

Chronic Recurrent Multifocal Osteomyelitis

Chronic Multifocal Osteomyelitis	CRMO
Cmo	Cno/Crmo
Chronic Nonbacterial Osteomyelitis/Chronic Recurrent Multifocal Osteomyelitis	Osteomyelitis, Chronic Multifocal
Multifocal Osteomyelitis, Chronic	Chronic Osteomyelitis
Chronic Multifocal Osteomyelitis, Unspecified Site	Crmo - [Chronic Multifocal Osteomyelitis]
Chronic Osteomyelitis With Draining Sinus, Unspecified Site	Bone Fistula With Chronic Osteomyelitis

Sarcoidosis 1

Sarcoidosis	Boeck Sarcoid
Besnier-Boeck-Schaumann Disease	SS1
Sarcoidosis, Susceptibility To, 1	Lymphogranulomatosis
Hodgkin Disease	Boeck'S Disease
Boeck'S Sarcoid	Schaumann'S Disease Or Syndrome
Hutchinson-Boeck Disease Or Syndrome

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behet'S Syndrome
Bd Syndrome	Behçet Syndrome
Behçet'S Disease	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Cholangitis

Acute Cholangiolitis	Ascending Cholangitis
Cholangiolitis	Cholangitis Nos
Chronic Cholangiolitis	Hepatic Duct Inflammation
Acute Cholangitis	Bile Duct Inflammation

Sigmoid Disease

Sigmoid Diseases

Toxoplasmosis

Disseminated Toxoplasmosis	Multisystemic Disseminated Toxoplasmosis
Acquired Toxoplasmosis	Toxoplasmosis Disease Or Disorder
Infection By Toxoplasma Gondii	Toxoplasmal
Toxoplasma

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Enteritis, Granulomatous	Crohn'S Disease Of Colon
Granulomatous Colitis	Colitis, Granulomatous
Crohn'S Enteritis	Enteritis, Regional
Enteritis	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

Crohn'S Colitis

Crohn Disease

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-13682	Mifamurtide	≥99.0%	Unkown
HY-13682B	Mifamurtide sodium	98.19%	Unkown
HY-13682C	Mifamurtide TFA	≥98.0%	Unkown

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100691	NOD-IN-1	Inhibitor	99.56%	Unkown
HY-147506	NOD2 antagonist 1	Antagonist	99.57%	Unkown
HY-168159	TLR7 agonist 27	Agonist	/	Unkown
HY-168010	RC529-MDP	Activator	/	Unkown
HY-146034	NOD1/2 antagonist-1	Antagonist	/	Unkown
HY-163274	NOD1 antagonist-1	Antagonist	/	Unkown
HY-168024	NOD1/2-IN-1	Inhibitor	/	Unkown
HY-168158	NOD2 agonist 3	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NOD2	VGNC	VGNC:67682
Macaca mulatta	NOD2	VGNC	VGNC:75297
Mus musculus	NOD2	MGD	MGI:2429397
Canis familiaris	NOD2	VGNC	VGNC:43878
Bos taurus	NOD2	VGNC	VGNC:32151
Rattus norvegicus	NOD2	RGD	RGD:1306368
Others	NOD2	NCBI