2. Gene
  3. HYPK - huntingtin interacting protein K Gene

HYPK - huntingtin interacting protein K Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HSPC136; C15orf63

Gene ID: 25764 | Gene type: protein coding

About HYPK

Cytogenetic location: 15q15.3 Genomic coordinates (GRCh38): 15:43,800,421-43,804,427 (from NCBI)

This gene has 5 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in fat (RPKM 18.1), prostate (RPKM 18.1) and 25 other tissues.

Summary

Enables protein N-terminus binding activity. Involved in negative regulation of apoptotic process and protein stabilization. Located in cytoplasm; microtubule cytoskeleton; and nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

HYPK Products(2)

mRNA Protein Name
NM_001199885.1 NP_001186814.1 huntingtin-interacting protein K isoform 2
NM_016400.4 NP_057484.4 huntingtin-interacting protein K isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17500595 GOA
enables protein folding chaperone EXP
EXP: Inferred from Experiment
18076027 GOA
enables protein folding chaperone IDA
IDA: Inferred from direct assay
18076027 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
17947297 GOA
involved in protein stabilization IDA
IDA: Inferred from direct assay
17947297 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17947297 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17947297 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
17947297 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

huntingtin-interacting protein K

huntingtin yeast partner K

HYPK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra HYPK Q9NX55 NAA15 Homo sapiens Q9BXJ9
Anti Tag CoIP
33961781
Intra HYPK Q9NX55 NAA15 Homo sapiens Q9BXJ9
TAP
24981860
Intra HYPK Q9NX55 TXLNA Homo sapiens P40222
Y2H Array
32296183
Intra HYPK Q9NX55 TXLNA Homo sapiens P40222
Y2H Prey Pooling
25416956
Intra HYPK Q9NX55 TXLNA Homo sapiens P40222
Validated Y2H
25416956
Intra HYPK Q9NX55 TXLNA Homo sapiens P40222
Y2H Prey Pooling
32296183
Intra HYPK Q9NX55 HTT Homo sapiens P42858
Y2H
17500595
Intra HYPK Q9NX55 MAGEA1 Homo sapiens P43355
Validated Y2H
25416956
Intra HYPK Q9NX55 MAGEA1 Homo sapiens P43355
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Microphthalmia, Syndromic 1

MCOPS1

Lenz Microphthalmia Syndrome

Lenz Dysplasia

Mcops4

Syndromic Microphthalmia 1

Lenz Microphthalmia

Maa

Microphthalmia Or Anophthalmos With Associated Anomalies

Syndromic Microphthalmia Type 4

Microphthalmia, Syndromic 4

Microphthalmia, Syndromic 4, Formerly

Mcops4, Formerly

Anop1, Formerly

Maa, Formerly

Lenz Type Microphthalmia

Syndromic Microphthalmia 4

Microphthalmia Lenz Type

Microphthalmia Syndromic 1

Syndromic Microphthalmia Type 1

Microphthalmia Syndromic 4

Microphthalmia With Ankyloblepharon And Intellectual Disability

Microphthalmia, Lenz Type

Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome

Microphthalmia, Syndromic, 1

Anop1

Microphthalmia, Syndromic, Type 1
46,Xx Sex Reversal 3

SRXX3

Chromosome Xq26 Duplication Syndrome

46,Xx Sex Reversal, Sox3-Related

46xx Sex Reversal 3

46,Xx Male Sex Reversal Sox3-Related
Ogden Syndrome

OGDNS

N-Terminal Acetyltransferase Deficiency

NATD

N-Alpha-Acetyltransferase

X-Linked Malformation And Infantile Lethality Syndrome

Premature Aging Appearance-Developmental Delay-Cardiac Arrhythmia Syndrome
Syndromic Microphthalmia

Microphthalmia, Syndromic
Dysgraphia

Agraphia
Developmental And Epileptic Encephalopathy 1

Epileptic Encephalopathy, Early Infantile, 1

Infantile Epileptic-Dyskinetic Encephalopathy

DEE1

Eiee1

Issx1

Xmesid

X-Linked Infantile Spasm Syndrome 1

X-Linked Infantile Spasm Syndrome

X-Linked Spasticity-Intellectual Disability-Epilepsy Syndrome

Developmental And Epileptic Encephalopathy, 1

Infantile Epileptic Dyskinetic Encephalopathy

Infantile Spasm Syndrome, X-Linked 1

West Syndrome, X-Linked

Ohtahara Syndrome, X-Linked

Early Infantile Epileptic Encephalopathy 1

Early Infantile Epileptic Encephalopathy-1

Issx

X-Linked Ohtahara Syndrome

X-Linked West Syndrome

Infantile Spasm Syndrome X-Linked 1

Myoclonic Epilepsy X-Linked With Intellectual Disability And Spasticity

Ohtahara Syndrome X-Linked

West Syndrome X-Linked

Encephalopathy, Epileptic, Early Infantile, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06504 HYPK Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HYPK VGNC VGNC:84350
Felis catus HYPK VGNC VGNC:62862
Bos taurus HYPK VGNC VGNC:30015
Rattus norvegicus HYPK RGD RGD:1311457
Mus musculus HYPK MGD MGI:1914943