NAA15 - N-alpha-acetyltransferase 15, NatA auxiliary subunit Gene

Homo sapiens

Also known as Ga19; NATH; TBDN; MRD50; NARG1; NAT1P; TBDN100

Gene ID: 80155 | Gene type: protein coding

About NAA15

Cytogenetic location: 4q31.1 Genomic coordinates (GRCh38): 4:139,301,505-139,391,384 (from NCBI)

This gene has 15 transcripts (splice variants), 273 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 10.4), lymph node (RPKM 9.1) and 25 other tissues.

Summary

N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017]

NAA15 Products(2)

mRNA	Protein	Name
NM_001410842.1	NP_001397771.1	N-alpha-acetyltransferase 15, NatA auxiliary subunit isoform 2
NM_057175.5	NP_476516.1	N-alpha-acetyltransferase 15, NatA auxiliary subunit isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to acetyltransferase activity	IDA IDA: Inferred from direct assay	15496142	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12145306	GOA
contributes to ribosome binding	IDA IDA: Inferred from direct assay	15496142	GOA
enables ribosome binding	IDA IDA: Inferred from direct assay	19480662	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in N-terminal protein amino acid acetylation	IDA IDA: Inferred from direct assay	15496142	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19480662	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12145306	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	19480662	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of NatA complex	IDA IDA: Inferred from direct assay	15496142	GOA
part of NatA complex	IPI IPI: Inferred from physical interaction	15496142	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12140756	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12140756	GOA
part of transcription regulator complex	IDA IDA: Inferred from direct assay	12145306	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAA15 Protein Structure

TPR_2

NARP1

0
200
400
600
800
866 a.a.

Protein Preferred Names

Protein Names

N-alpha-acetyltransferase 15, NatA auxiliary subunit

N-terminal acetyltransferase

NAA15 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NAA15	Q9BXJ9	HYPK	Homo sapiens	Q9NX55	Anti Tag CoIP	28514442
Intra	NAA15	Q9BXJ9	HYPK	Homo sapiens	Q9NX55	Validated Y2H	32296183
Intra	NAA15	Q9BXJ9	HYPK	Homo sapiens	Q9NX55	Y2H Prey Pooling	32296183
Intra	NAA15	Q9BXJ9	HYPK	Homo sapiens	Q9NX55	Y2H Array	32296183
Intra	NAA15	Q9BXJ9	NAA50	Homo sapiens	Q9GZZ1	Anti Tag CoIP	33961781
Intra	NAA15	Q9BXJ9	NAA50	Homo sapiens	Q9GZZ1	Anti Tag CoIP	28514442
Intra	NAA15	Q9BXJ9	NAA11	Homo sapiens	Q9BSU3	Anti Tag CoIP	16638120
Intra	NAA15	Q9BXJ9	NAA10	Homo sapiens	P41227	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Dominant 50, With Behavioral Abnormalities

Mental Retardation, Autosomal Dominant 50	MRD50
Autosomal Dominant Intellectual Developmental Disorder 50	Autosomal Dominant Intellectual Developmental Disorder-50 With Behavioral Abnormalities
Autosomal Dominant Mental Retardation 50

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Ogden Syndrome

OGDNS	N-Terminal Acetyltransferase Deficiency
NATD	N-Alpha-Acetyltransferase
X-Linked Malformation And Infantile Lethality Syndrome	Premature Aging Appearance-Developmental Delay-Cardiac Arrhythmia Syndrome

Microphthalmia, Syndromic 1

MCOPS1	Lenz Microphthalmia Syndrome
Lenz Dysplasia	Mcops4
Syndromic Microphthalmia 1	Lenz Microphthalmia
Maa	Microphthalmia Or Anophthalmos With Associated Anomalies
Syndromic Microphthalmia Type 4	Microphthalmia, Syndromic 4
Microphthalmia, Syndromic 4, Formerly	Mcops4, Formerly
Anop1, Formerly	Maa, Formerly
Lenz Type Microphthalmia	Syndromic Microphthalmia 4
Microphthalmia Lenz Type	Microphthalmia Syndromic 1
Syndromic Microphthalmia Type 1	Microphthalmia Syndromic 4
Microphthalmia With Ankyloblepharon And Intellectual Disability	Microphthalmia, Lenz Type
Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome	Microphthalmia, Syndromic, 1
Anop1	Microphthalmia, Syndromic, Type 1

Intellectual Developmental Disorder, Autosomal Dominant 10

MRD10	Mental Retardation, Autosomal Dominant 10
Autosomal Dominant Non-Syndromic Intellectual Disability 10	Autosomal Dominant Intellectual Developmental Disorder 10
Autosomal Dominant Mental Retardation 10	Mental Retardation, Autosomal Dominant, Type 10

Microcephaly And Chorioretinopathy 2

Syndromic Microphthalmia

Microphthalmia, Syndromic

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Uterine Corpus Endometrial Carcinoma

Smith-Mccort Dysplasia 1

Smith-Mccort Dysplasia	SMC1
Smc	Smith Mccort Dysplasia
Smith-Mccort Dwarfism

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08986	NAA15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NAA15	VGNC	VGNC:78529
Bos taurus	NAA15	VGNC	VGNC:53913
Rattus norvegicus	NAA15	RGD	RGD:1310984
Macaca mulatta	NAA15	VGNC	VGNC:96715
Canis familiaris	NAA15	VGNC	VGNC:54810
Mus musculus	NAA15	MGD	MGI:1922088

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