2. Gene
  3. CBY1 - chibby family member 1, beta catenin antagonist Gene

CBY1 - chibby family member 1, beta catenin antagonist Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CBY; arb1; PGEA1; C22orf2; Chibby1; PIGEA14; PIGEA-14; HS508I15A

Gene ID: 25776 | Gene type: protein coding

About CBY1

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:38,656,638-38,673,850 (from NCBI)

This gene has 10 transcripts (splice variants), 188 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in prostate (RPKM 16.6), adrenal (RPKM 16.3) and 25 other tissues.

Summary

Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CBY1 Products(2)

mRNA Protein Name
NM_001002880.4 NP_001002880.3 protein chibby homolog 1
NM_015373.4 NP_056188.1 protein chibby homolog 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables beta-catenin binding IDA
IDA: Inferred from direct assay
12712206 GOA
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
16424001 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
15194699 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15194699 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
21182262 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12712206 GOA
involved in negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
12712206 GOA
involved in protein homotetramerization IDA
IDA: Inferred from direct assay
21182262 GOA
involved in protein localization IMP
IMP: Inferred from mutant phenotype
15194699 GOA
Cellular Component GO Annotation Evidence Reference Source
located in centriole IDA
IDA: Inferred from direct assay
22911743 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12712206 GOA
located in trans-Golgi network IDA
IDA: Inferred from direct assay
15194699 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CBY1 Protein Structure

Chibby

Chibby: Chibby family (1 - 117)

  • 0
  • 100
  • 126 a.a.
Protein Preferred Names Protein Names

protein chibby homolog 1

ARPP-binding protein

CBY1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CBY1 Q9Y3M2 TTC23L Homo sapiens Q6PF05-3
Y2H Array
25416956
Intra
CBY1 Q9Y3M2 DZIP1L Homo sapiens Q8IYY4
Anti Tag CoIP
33961781
Intra
CBY1 Q9Y3M2 CIBAR1 Homo sapiens A1XBS5
Anti Tag CoIP
33961781
Intra
CBY1 Q9Y3M2 CIBAR1 Homo sapiens A1XBS5
Y2H Prey Pooling
25416956
Intra
CBY1 Q9Y3M2 CIBAR1 Homo sapiens A1XBS5
Y2H Array
25416956
Intra
CBY1 Q9Y3M2 YWHAZ Homo sapiens P63104
Anti Tag CoIP
33961781
Intra
CBY1 Q9Y3M2 YWHAZ Homo sapiens P63104
CoIP
18573912
Intra
CBY1 Q9Y3M2 YWHAE Homo sapiens P62258
TAP
27173435
Intra
CBY1 Q9Y3M2 YWHAE Homo sapiens P62258
CoIP
18573912
Intra
CBY1 Q9Y3M2 CFAP53 Homo sapiens Q96M91
Lumier
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Joubert Syndrome 1

Joubert Syndrome

Jbts

Cerebellooculorenal Syndrome 1

JBTS1

Joubert-Boltshauser Syndrome

Cerebelloparenchymal Disorder Iv

Cpd4

Cors1

Joubert Syndrome And Related Disorders

Jsrd

Familial Aplasia Of The Vermis

Joubert Syndrome Related Disorders

Js

Cerebellar Vermis Agenesis

Cerebelloparenchymal Disorder 4

Agenesis Of Cerebellar Vermis

Cerebello-Oculo-Renal Syndrome

Cors

Joubert-Bolthauser Syndrome

Cpd Iv

Classic Joubert Syndrome

Joubert Syndrome Type A

Pure Joubert Syndrome

Cerebello-Oculo-Renal Syndrome 1

Joubert Syndrome-1

Joubert Syndrome, Type 1

Joubert'S Syndrome
Ulcerative Blepharitis
Macular Degeneration, Age-Related, 9

Age Related Macular Degeneration 9

ARMD9

Macular Degeneration, Age-Related, 9, Susceptibility To

Macular Degeneration, Age-Related, Type 9
Granulomatous Orchitis

Non-Specific Granulomatous Orchitis
Myringitis Bullosa Hemorrhagica

Bullous Myringitis
Macular Degeneration, Age-Related, 14

Age Related Macular Degeneration 14

ARMD14

Macular Degeneration, Age-Related, 14, Reduced Risk Of

Macular Degeneration, Age-Related, Type 14
Nephronophthisis

Medullary Cystic Disease

Medullary Cystic Kidney

Nph

Nphp

Kidney Disease, Cystic, Medullary
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02016 CBY1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CBY1 VGNC VGNC:26822
Mus musculus CBY1 MGD MGI:1920989
Felis catus CBY1 VGNC VGNC:60427
Canis familiaris CBY1 VGNC VGNC:38770
Macaca mulatta CBY1 VGNC VGNC:107103
Rattus norvegicus CBY1 RGD RGD:708481