NGEF - neuronal guanine nucleotide exchange factor Gene

Homo sapiens

Also known as EPHEXIN; ARHGEF27

Gene ID: 25791 | Gene type: protein coding

About NGEF

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:232,878,701-233,013,256 (from NCBI)

This gene has 9 transcripts (splice variants), 200 orthologues and 6 paralogues. Biased expression in brain (RPKM 32.1), duodenum (RPKM 14.9) and 8 other tissues.

Summary

Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including activation of GTPase activity; Ephrin Receptor signaling pathway; and negative regulation of dendritic spine morphogenesis. Predicted to be located in cytosol. Predicted to be active in glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2022]

NGEF Products(2)

mRNA	Protein	Name
NM_001114090.2	NP_001107562.1	ephexin-1 isoform 2
NM_019850.3	NP_062824.2	ephexin-1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables guanyl-nucleotide exchange factor activity	EXP EXP: Inferred from Experiment	15848799	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NGEF Protein Structure

RhoGEF

SH3_1

0
200
400
600
710 a.a.

Protein Preferred Names

Protein Names

ephexin-1

eph-interacting exchange protein

NGEF Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NGEF	Q8N5V2	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	NGEF	Q8N5V2	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	NGEF	Q8N5V2	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	NGEF	Q8N5V2	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	NGEF	Q8N5V2	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	NGEF	Q8N5V2	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	NGEF	Q8N5V2	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	NGEF	Q8N5V2	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	NGEF	Q8N5V2	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	NGEF	Q8N5V2	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	NGEF	Q8N5V2	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	NGEF	Q8N5V2	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	NGEF	Q8N5V2	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	NGEF	Q8N5V2	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	NGEF	Q8N5V2	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	NGEF	Q8N5V2	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	NGEF	Q8N5V2	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	NGEF	Q8N5V2	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	NGEF	Q8N5V2	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	NGEF	Q8N5V2	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	NGEF	Q8N5V2	WFS1	Homo sapiens	O76024	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hypogonadotropic Hypogonadism 6 With Or Without Anosmia

HH6	Kallmann Syndrome 6
Kal6	Hypogonadotropic Hypogonadism, Type 6 With/Without Anosmia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09276	NGEF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NGEF	MGD	MGI:1858414
Rattus norvegicus	NGEF	RGD	RGD:1309055
Felis catus	NGEF	VGNC	VGNC:80292
Bos taurus	NGEF	VGNC	VGNC:32060
Macaca mulatta	NGEF	VGNC	VGNC:75345
Canis familiaris	NGEF	VGNC	VGNC:43795

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