RAB26 - RAB26, member RAS oncogene family Gene

Homo sapiens

Also known as V46133

Gene ID: 25837 | Gene type: protein coding

About RAB26

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,148,144-2,154,165 (from NCBI)

This gene has 8 transcripts (splice variants), 250 orthologues and 68 paralogues. Broad expression in brain (RPKM 4.5), salivary gland (RPKM 3.5) and 15 other tissues.

Summary

Members of the RAB protein family, including RAB26, are important regulators of vesicular fusion and trafficking. The RAB family of small G proteins regulates intercellular vesicle trafficking, including exocytosis, endocytosis, and recycling (summary by Seki et al., 2000 [PubMed 11043516]).[supplied by OMIM, Nov 2010]

RAB26 Products(2)

mRNA	Protein	Name
NM_001308053.1	NP_001294982.1	ras-related protein Rab-26 isoform 2
NM_014353.5	NP_055168.2	ras-related protein Rab-26 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GMP binding	IMP IMP: Inferred from mutant phenotype	23105096	GOA
enables GTP binding	IMP IMP: Inferred from mutant phenotype	23105096	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23105096	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi to plasma membrane protein transport	IMP IMP: Inferred from mutant phenotype	23105096	GOA
involved in exocrine system development	IMP IMP: Inferred from mutant phenotype	20038531	GOA
involved in regulated exocytosis	IMP IMP: Inferred from mutant phenotype	20038531	GOA
involved in regulation protein catabolic process at presynapse	IDA IDA: Inferred from direct assay	29084947	GOA
involved in regulation protein catabolic process at presynapse	IMP IMP: Inferred from mutant phenotype	29084947	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	23105096	GOA
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	25643395	GOA
is active in synaptic vesicle membrane	IMP IMP: Inferred from mutant phenotype	25643395	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB26 Protein Structure

Ras

0
100
200
256 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-26

Ras-related oncogene protein

RAB26 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAB26	Q9ULW5	KRT33B	Homo sapiens	Q14525	Y2H Array	32296183
Intra	RAB26	Q9ULW5	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	32296183
Intra	RAB26	Q9ULW5	UNKL	Homo sapiens	Q9H9P5-5	Y2H Array	32296183
Intra	RAB26	Q9ULW5	UNKL	Homo sapiens	Q9H9P5-5	Y2H Prey Pooling	32296183
Intra	RAB26	Q9ULW5	OIP5	Homo sapiens	O43482	Y2H Array	32296183
Intra	RAB26	Q9ULW5	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	32296183
Intra	RAB26	Q9ULW5	FHL5	Homo sapiens	Q5TD97	Y2H Array	32296183
Intra	RAB26	Q9ULW5	ADRA2B	Homo sapiens	P18089	Anti Bait CoIP	23105096
Intra	RAB26	Q9ULW5	ADRA2B	Homo sapiens	P18089	Pull Down	23105096
Intra	RAB26	Q9ULW5	ADRA2B	Homo sapiens	P18089	BRET	23105096

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spastic Paraplegia 15, Autosomal Recessive

SPG15	Kjellin Syndrome
Hereditary Spastic Paraplegia 15	Spastic Paraplegia And Retinal Degeneration
Autosomal Recessive Spastic Paraplegia Type 15	Hereditary Spastic Paraparesis Type 15
Spastic Paraplegia-Retinal Degeneration Syndrome	Autosomal Recessive Spastic Paraplegia 15

Spinal Muscular Atrophy, Distal, Autosomal Recessive, 4

DSMA4	Autosomal Recessive Lower Motor Neuron Disease With Childhood Onset
Distal Spinal Muscular Atrophy Type 4	Autosomal Recessive Distal Spinal Muscular Atrophy Type 4
Distal Spinal Muscular Atrophy, Autosomal Recessive, 4	Atrophy, Muscular, Spinal, Distal, Autosomal Recessive, Type 4

Spinal Muscular Atrophy, Type Iv

SMA4	Spinal Muscular Atrophy, Adult Form
Spinal Muscular Atrophy 4	Spinal Muscular Atrophy-4
Adult Spinal Muscular Atrophy	Spinal Muscular Atrophy, Proximal, Adult, Autosomal Recessive
Proximal Spinal Muscular Atrophy Type 4	Sma Type 4
Sma Type Iv	Sma-Iv
Sma Iv	Spinal Muscular Atrophy Adult Form
Spinal Muscular Atrophy Proximal Adult Autosomal Recessive	Spinal Muscular Atrophy Type Iv
Atrophy, Muscular, Spinal, Type Iv	Myelopathic Muscular Atrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11536	RAB26 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RAB26	VGNC	VGNC:80677
Mus musculus	RAB26	MGD	MGI:2443284
Bos taurus	RAB26	VGNC	VGNC:33633
Macaca mulatta	RAB26	VGNC	VGNC:81526
Rattus norvegicus	RAB26	RGD	RGD:620890
Canis familiaris	RAB26	VGNC	VGNC:45266

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