2. Gene
  3. KRT33B - keratin 33B Gene

KRT33B - keratin 33B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as K33B; HA3II; Ha-3II; KRTHA3A; KRTHA3B; hHa3-II

Gene ID: 3884 | Gene type: protein coding

About KRT33B

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:41,363,498-41,369,813 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 45 orthologues and 68 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the keratin gene family. This gene is one of multiple type I hair keratin genes that are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. As a type I hair keratin, the encoded protein is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, keratin 33A and keratin 33B. [provided by RefSeq, May 2012]

KRT33B Products(1)

mRNA Protein Name
NM_002279.5 NP_002270.1 keratin, type I cuticular Ha3-II
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
23455924 GOA
Biological Process GO Annotation Evidence Reference Source
involved in hair cycle IDA
IDA: Inferred from direct assay
21916889 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT33B Protein Structure

Filament

Filament: Intermediate filament protein (55 - 366)

  • 0
  • 100
  • 200
  • 300
  • 404 a.a.
Protein Preferred Names Protein Names

keratin, type I cuticular Ha3-II

hair keratin, type I Ha3-II

KRT33B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
KRT33B Q14525 NF2 Homo sapiens P35240
Validated Y2H
32814053
Intra
KRT33B Q14525 NF2 Homo sapiens P35240
Y2H Pooling
32814053
Intra
KRT33B Q14525 NF2 Homo sapiens P35240
Y2H Array
32814053
Intra
KRT33B Q14525 RTP5 Homo sapiens Q14D33
Validated Y2H
32296183
Intra
KRT33B Q14525 GOLGA6L2 Homo sapiens Q8N9W4-2
Validated Y2H
32296183
Intra
KRT33B Q14525 KRT82 Homo sapiens Q9NSB4
Validated Y2H
32296183
Intra
KRT33B Q14525 KRT78 Homo sapiens Q8N1N4
Complementation
32296183
Intra
KRT33B Q14525 KRT78 Homo sapiens Q8N1N4
Validated Y2H
32296183
Intra
KRT33B Q14525 KRT78 Homo sapiens Q8N1N4
MAPPIT
32296183
Intra
KRT33B Q14525 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
KRT33B Q14525 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
KRT33B Q14525 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
KRT33B Q14525 PATZ1 Homo sapiens Q9HBE1-4
Validated Y2H
32296183
Intra
KRT33B Q14525 CCDC24 Homo sapiens Q8N4L8
Validated Y2H
32296183
Intra
KRT33B Q14525 HAPLN2 Homo sapiens Q9GZV7
Validated Y2H
32296183
Intra
KRT33B Q14525 KRT80 Homo sapiens Q6KB66-2
Validated Y2H
32296183
Intra
KRT33B Q14525 ATG9A Homo sapiens Q7Z3C6-3
Validated Y2H
32296183
Intra
KRT33B Q14525 KRT72 Homo sapiens Q14CN4
Validated Y2H
32296183
Intra
KRT33B Q14525 KRT4 Homo sapiens P19013
Validated Y2H
25416956
Intra
KRT33B Q14525 KRT79 Homo sapiens Q5XKE5
Y2H Array
31515488
Intra
KRT33B Q14525 KRT79 Homo sapiens Q5XKE5
Validated Y2H
25416956
Intra
KRT33B Q14525 KRT79 Homo sapiens Q5XKE5
Validated Y2H
32296183
Intra
KRT33B Q14525 KRT79 Homo sapiens Q5XKE5
Y2H Prey Pooling
25416956
Intra
KRT33B Q14525 PPP1R18 Homo sapiens Q6NYC8
Validated Y2H
32296183
Intra
KRT33B Q14525 q9y649_human Homo sapiens Q9Y649
Validated Y2H
32814053
Intra
KRT33B Q14525 q9y649_human Homo sapiens Q9Y649
Y2H Array
32814053
Intra
KRT33B Q14525 q9y649_human Homo sapiens Q9Y649
Y2H Pooling
32814053
Intra
KRT33B Q14525 NUP58 Homo sapiens Q9BVL2
Validated Y2H
32296183
Intra
KRT33B Q14525 KRT71 Homo sapiens Q3SY84
Validated Y2H
32296183
Intra
KRT33B Q14525 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
KRT33B Q14525 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
KRT33B Q14525 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
KRT33B Q14525 HRAS Homo sapiens P01112
Validated Y2H
32814053
Intra
KRT33B Q14525 HRAS Homo sapiens P01112
Y2H Array
32814053
Intra
KRT33B Q14525 HRAS Homo sapiens P01112
Y2H Pooling
32814053
Intra
KRT33B Q14525 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
KRT33B Q14525 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
KRT33B Q14525 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
KRT33B Q14525 CCT5 Homo sapiens P48643
Y2H Array
32814053
Intra
KRT33B Q14525 CCT5 Homo sapiens P48643
Validated Y2H
32814053
Intra
KRT33B Q14525 CCT5 Homo sapiens P48643
Y2H Pooling
32814053
Intra
KRT33B Q14525 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra
KRT33B Q14525 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra
KRT33B Q14525 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra
KRT33B Q14525 NEFL Homo sapiens P07196
Y2H Pooling
32814053
Intra
KRT33B Q14525 NEFL Homo sapiens P07196
Validated Y2H
32814053
Intra
KRT33B Q14525 NEFL Homo sapiens P07196
Y2H Array
32814053
Intra
KRT33B Q14525 HTRA2 Homo sapiens O43464
Validated Y2H
32814053
Intra
KRT33B Q14525 HTRA2 Homo sapiens O43464
Y2H Array
32814053
Intra
KRT33B Q14525 HTRA2 Homo sapiens O43464
Y2H Pooling
32814053
Intra
KRT33B Q14525 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
KRT33B Q14525 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
KRT33B Q14525 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
KRT33B Q14525 NDUFV2 Homo sapiens P19404
Validated Y2H
32814053
Intra
KRT33B Q14525 NDUFV2 Homo sapiens P19404
Y2H Array
32814053
Intra
KRT33B Q14525 NDUFV2 Homo sapiens P19404
Y2H Pooling
32814053
Intra
KRT33B Q14525 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
KRT33B Q14525 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
KRT33B Q14525 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
KRT33B Q14525 DUSP21 Homo sapiens Q9H596
Validated Y2H
32296183
Intra
KRT33B Q14525 CNNM3 Homo sapiens Q8NE01
Validated Y2H
32296183
Intra
KRT33B Q14525 NUP54 Homo sapiens Q7Z3B4
Validated Y2H
32296183
Intra
KRT33B Q14525 SGF29 Homo sapiens Q96ES7
Validated Y2H
32296183
Intra
KRT33B Q14525 ABI2 Homo sapiens Q9NYB9
Validated Y2H
25416956
Intra
KRT33B Q14525 ABI2 Homo sapiens Q9NYB9
Y2H Array
25416956
Intra
KRT33B Q14525 RAMAC Homo sapiens Q9BTL3
Validated Y2H
32296183
Intra
KRT33B Q14525 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Intra
KRT33B Q14525 GFAP Homo sapiens P14136
Validated Y2H
32814053
Intra
KRT33B Q14525 GFAP Homo sapiens P14136
Y2H Array
32814053
Intra
KRT33B Q14525 AQP1 Homo sapiens P29972
Y2H Prey Pooling
25416956
Intra
KRT33B Q14525 AQP1 Homo sapiens P29972
Validated Y2H
25416956
Intra
KRT33B Q14525 C1orf216 Homo sapiens Q8TAB5
Validated Y2H
32296183
Intra
KRT33B Q14525 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
32296183
Intra
KRT33B Q14525 PRPS1 Homo sapiens P60891
Validated Y2H
32814053
Intra
KRT33B Q14525 PRPS1 Homo sapiens P60891
Y2H Array
32814053
Intra
KRT33B Q14525 PRPS1 Homo sapiens P60891
Y2H Pooling
32814053
Intra
KRT33B Q14525 PRPH Homo sapiens P41219
Y2H Pooling
32814053
Intra
KRT33B Q14525 PRPH Homo sapiens P41219
Validated Y2H
32814053
Intra
KRT33B Q14525 PRPH Homo sapiens P41219
Y2H Array
32814053
Intra
KRT33B Q14525 SHC3 Homo sapiens Q92529
Validated Y2H
32296183
Intra
KRT33B Q14525 KLC4 Homo sapiens Q9NSK0
Validated Y2H
32296183
Intra
KRT33B Q14525 RAB26 Homo sapiens Q9ULW5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Skin Pilomatrix Carcinoma

Pilomatrix Carcinoma Of Skin

Malignant Pilomatricoma

Pilomatricoma, Malignant
Loose Anagen Hair Syndrome

Loose Anagen Syndrome

LAHS
T-Cell Immunodeficiency With Thymic Aplasia

Nezelof Syndrome

T-Lymphocyte Deficiency

TIDTA

Immune Defect Due To Absence Of Thymus

Thymic Aplasia

Nezelof'S Syndrome

Thymic Dysplasia With Normal Immunoglobulins

Thymic Aplasia Syndrome

T-Lymphocyte Immunodeficiency
Rapidly Involuting Congenital Hemangioma

Rich
Hair Follicle Neoplasm

Hair Matrix Neoplasm

Hair Matrix Tumour
Monilethrix

Beaded Hair

MNLIX

Nodose Hair

Moniliform Hair Syndrome
Pilomatrixoma

Pilomatricoma

PTR

Epithelioma Calcificans Of Malherbe

Benign Pilomatricoma

Calcifying Epithelioma Of Malherbe

Pilomatricoma, Somatic

Benign Pilomatrixoma

Malherbe Calcifying Epithelioma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07452 KRT33B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus KRT33B MGD MGI:1309991