KRT33B - keratin 33B Gene

Homo sapiens

Also known as K33B; HA3II; Ha-3II; KRTHA3A; KRTHA3B; hHa3-II

Gene ID: 3884 | Gene type: protein coding

About KRT33B

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:41,363,498-41,369,813 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 45 orthologues and 68 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the keratin gene family. This gene is one of multiple type I hair keratin genes that are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. As a type I hair keratin, the encoded protein is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, keratin 33A and keratin 33B. [provided by RefSeq, May 2012]

KRT33B Products(1)

mRNA	Protein	Name
NM_002279.5	NP_002270.1	keratin, type I cuticular Ha3-II

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23455924	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in hair cycle	IDA IDA: Inferred from direct assay	21916889	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT33B Protein Structure

Filament

0
100
200
300
404 a.a.

Protein Preferred Names

Protein Names

keratin, type I cuticular Ha3-II

hair keratin, type I Ha3-II

Related Diseases

Diseases

Alias

Skin Pilomatrix Carcinoma

Pilomatrix Carcinoma Of Skin	Malignant Pilomatricoma
Pilomatricoma, Malignant

Loose Anagen Hair Syndrome

Loose Anagen Syndrome

LAHS

T-Cell Immunodeficiency With Thymic Aplasia

Nezelof Syndrome	T-Lymphocyte Deficiency
TIDTA	Immune Defect Due To Absence Of Thymus
Thymic Aplasia	Nezelof'S Syndrome
Thymic Dysplasia With Normal Immunoglobulins	Thymic Aplasia Syndrome
T-Lymphocyte Immunodeficiency

Rapidly Involuting Congenital Hemangioma

Rich

Hair Follicle Neoplasm

Hair Matrix Neoplasm

Hair Matrix Tumour

Monilethrix

Beaded Hair	MNLIX
Nodose Hair	Moniliform Hair Syndrome

Pilomatrixoma

Pilomatricoma	PTR
Epithelioma Calcificans Of Malherbe	Benign Pilomatricoma
Calcifying Epithelioma Of Malherbe	Pilomatricoma, Somatic
Benign Pilomatrixoma	Malherbe Calcifying Epithelioma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07452	KRT33B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KRT33B	MGD	MGI:1309991

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