2. Gene
  3. USP49 - ubiquitin specific peptidase 49 Gene

USP49 - ubiquitin specific peptidase 49 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 25862 | Gene type: protein coding

About USP49

This gene has 6 transcripts (splice variants), 206 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 2.1), thyroid (RPKM 1.8) and 25 other tissues.

Summary

Enables cysteine-type endopeptidase activity; histone binding activity; and thiol-dependent Deubiquitinase. Involved in histone H2B conserved C-terminal lysine deubiquitination and mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

USP49 Products(3)

mRNA Protein Name
NM_001286554.2 NP_001273483.1 ubiquitin carboxyl-terminal hydrolase 49 isoform a
NM_001384542.1 NP_001371471.1 ubiquitin carboxyl-terminal hydrolase 49 isoform a
NM_018561.5 NP_061031.2 ubiquitin carboxyl-terminal hydrolase 49 isoform b
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
14715245 GOA
enables cysteine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
23824326 GOA
enables histone H2B deubiquitinase activity IDA
IDA: Inferred from direct assay
23824326 GOA
enables histone binding IDA
IDA: Inferred from direct assay
23824326 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19615732 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
23824326 GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
28363942 GOA
involved in protein deubiquitination IDA
IDA: Inferred from direct assay
28363942 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP49 Protein Structure

zf-UBP

zf-UBP: Zn-finger in ubiquitin-hydrolases and other protein (26 - 87)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (252 - 654)

  • 0
  • 200
  • 400
  • 600
  • 688 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 49

deubiquitinating enzyme 49

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15560 USP49 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris USP49 VGNC VGNC:48200
Bos taurus USP49 VGNC VGNC:36734
Felis catus USP49 VGNC VGNC:66892
Mus musculus USP49 MGD MGI:2685391
Rattus norvegicus USP49 RGD RGD:1310513
Macaca mulatta USP49 VGNC VGNC:79231