PRKD2 - protein kinase D2 Gene

Homo sapiens

Also known as PKD2; HSPC187; nPKC-D2

Gene ID: 25865 | Gene type: protein coding

About PRKD2

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:46,674,316-46,717,114 (from NCBI)

This gene has 17 transcripts (splice variants), 190 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 19.7), lymph node (RPKM 14.5) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by Gastrin via the cholecystokinin B receptor (CCKBR) in gastric Cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

PRKD2 Products(4)

mRNA	Protein	Name
NM_001079880.2	NP_001073349.1	serine/threonine-protein kinase D2 isoform A
NM_001079881.2	NP_001073350.1	serine/threonine-protein kinase D2 isoform A
NM_001079882.2	NP_001073351.1	serine/threonine-protein kinase D2 isoform B
NM_016457.5	NP_057541.2	serine/threonine-protein kinase D2 isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17962809	GOA
enables protein kinase C binding	IPI IPI: Inferred from physical interaction	28428613	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	17077180	GOA
enables protein serine kinase activity	IGI IGI: Inferred from genetic interaction	20497126	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	18440775	GOA
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	28428613	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	17077180	GOA
involved in cellular response to vascular endothelial growth factor stimulus	IGI IGI: Inferred from genetic interaction	20497126	GOA
involved in cellular response to vascular endothelial growth factor stimulus	IMP IMP: Inferred from mutant phenotype	18059339	GOA
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	18059339	GOA
involved in peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	28428613	GOA
involved in peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	28428613	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	19192391	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	15604256	GOA
involved in positive regulation of angiogenesis	IGI IGI: Inferred from genetic interaction	20497126	GOA
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	18440775	GOA
involved in positive regulation of blood vessel endothelial cell migration	IGI IGI: Inferred from genetic interaction	20497126	GOA
involved in positive regulation of blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	18440775	GOA
involved in positive regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	17951978	GOA
involved in positive regulation of endothelial cell chemotaxis	IGI IGI: Inferred from genetic interaction	20497126	GOA
involved in positive regulation of endothelial cell chemotaxis	IMP IMP: Inferred from mutant phenotype	18440775	GOA
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	19001381	GOA
involved in positive regulation of endothelial cell proliferation	IGI IGI: Inferred from genetic interaction	20497126	GOA
involved in positive regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	19001381	GOA
involved in positive regulation of fibroblast growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19001381	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	16928771	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17077180	GOA
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	20497126	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18059339	GOA
involved in positive regulation of vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19001381	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	17077180	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	22228765	GOA
involved in regulation of T cell apoptotic process	IMP IMP: Inferred from mutant phenotype	17077180	GOA
involved in vascular endothelial growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	20497126	GOA
involved in vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18059339	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17077180	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17077180	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKD2 Protein Structure

C1_1

Pkinase

0
200
400
600
800
878 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase D2

PRKD2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRKD2	Q9BZL6	HDAC7	Homo sapiens	Q8WUI4	Anti Tag CoIP	17962809
Intra	PRKD2	Q9BZL6	HDAC7	Homo sapiens	Q8WUI4	Pull Down	17962809
Intra	PRKD2	Q9BZL6	HDAC7	Homo sapiens	Q8WUI4	Anti Bait CoIP	17962809
Intra	PRKD2	Q9BZL6	HDAC7	Homo sapiens	Q8WUI4	Protein Kinase Assay	17962809
Intra	PRKD2	Q9BZL6	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRKD2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74615	Protein Kinase D2/PRKD2 Protein, Human (sf9, His-GST)	Q9BZL6-1/ NP_057541.2 (M1-L878)	≥95%

Related Diseases

Diseases

Alias

Angiolipoma

Conventional Lipoma

Classic Type Lipoma

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11147	PRKD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PRKD2	MGD	MGI:2141917
Macaca mulatta	PRKD2	VGNC	VGNC:76273
Bos taurus	PRKD2	VGNC	VGNC:33337
Canis familiaris	PRKD2	VGNC	VGNC:44987
Felis catus	PRKD2	VGNC	VGNC:64356
Rattus norvegicus	PRKD2	RGD	RGD:1308054
Others	PRKD2	NCBI

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