PRKD2 - protein kinase D2 Gene

Homo sapiens

Also known as PKD2; HSPC187; nPKC-D2

Gene ID: 25865 | Gene type: protein coding

About PRKD2

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:46,674,316-46,717,114 (from NCBI)

This gene has 17 transcripts (splice variants), 190 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 19.7), lymph node (RPKM 14.5) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by Gastrin via the cholecystokinin B receptor (CCKBR) in gastric Cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

PRKD2 Products(4)

mRNA	Protein	Name
NM_001079880.2	NP_001073349.1	serine/threonine-protein kinase D2 isoform A
NM_001079881.2	NP_001073350.1	serine/threonine-protein kinase D2 isoform A
NM_001079882.2	NP_001073351.1	serine/threonine-protein kinase D2 isoform B
NM_016457.5	NP_057541.2	serine/threonine-protein kinase D2 isoform A

PRKD2 Protein Structure

C1_1

Pkinase

0
200
400
600
800
878 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase D2

Recombinant PRKD2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74615	Protein Kinase D2/PRKD2 Protein, Human (sf9, His-GST)	Q9BZL6-1/ NP_057541.2 (M1-L878)	≥95%

Related Diseases

Diseases

Alias

Angiolipoma

Conventional Lipoma

Classic Type Lipoma

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11147	PRKD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PRKD2	MGD	MGI:2141917
Macaca mulatta	PRKD2	VGNC	VGNC:76273
Bos taurus	PRKD2	VGNC	VGNC:33337
Canis familiaris	PRKD2	VGNC	VGNC:44987
Felis catus	PRKD2	VGNC	VGNC:64356
Rattus norvegicus	PRKD2	RGD	RGD:1308054
Others	PRKD2	NCBI

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