2. Gene
  3. SUMF2 - sulfatase modifying factor 2 Gene

SUMF2 - sulfatase modifying factor 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as pFGE

Gene ID: 25870 | Gene type: protein coding

About SUMF2

Cytogenetic location: 7p11.2 Genomic coordinates (GRCh38): 7:56,064,286-56,087,946 (from NCBI)

This gene has 23 transcripts (splice variants), 105 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 45.6), kidney (RPKM 41.8) and 25 other tissues.

Summary

The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by Enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

SUMF2 Products(9)

mRNA Protein Name
NM_001042468.3 NP_001035933.3 inactive C-alpha-formylglycine-generating enzyme 2 isoform a precursor
NM_001042469.3 NP_001035934.3 inactive C-alpha-formylglycine-generating enzyme 2 isoform c precursor
NM_001042470.3 NP_001035935.3 inactive C-alpha-formylglycine-generating enzyme 2 isoform d precursor
NM_001130069.4 NP_001123541.2 inactive C-alpha-formylglycine-generating enzyme 2 isoform e precursor
NM_001146333.3 NP_001139805.1 inactive C-alpha-formylglycine-generating enzyme 2 isoform g
NM_001366647.2 NP_001353576.1 inactive C-alpha-formylglycine-generating enzyme 2 isoform h precursor
NM_001366648.2 NP_001353577.1 inactive C-alpha-formylglycine-generating enzyme 2 isoform i precursor
NM_001366649.2 NP_001353578.1 inactive C-alpha-formylglycine-generating enzyme 2 isoform j
NM_015411.4 NP_056226.3 inactive C-alpha-formylglycine-generating enzyme 2 isoform b precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
15962010 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15962010 GOA
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
18266766 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUMF2 Protein Structure

FGE-sulfatase

FGE-sulfatase: Sulfatase-modifying factor enzyme 1 (46 - 246)

  • 0
  • 100
  • 200
  • 300
  • 358 a.a.
Protein Preferred Names Protein Names

inactive C-alpha-formylglycine-generating enzyme 2

C-alpha-formyglycine-generating enzyme 2

SUMF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra SUMF2 Q8NBJ7 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra SUMF2 Q8NBJ7 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra SUMF2 Q8NBJ7 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra SUMF2 Q8NBJ7 CTSD Homo sapiens P07339
Y2H Pooling
32814053
Intra SUMF2 Q8NBJ7 CTSD Homo sapiens P07339
Validated Y2H
32814053
Intra SUMF2 Q8NBJ7 CTSD Homo sapiens P07339
Y2H Array
32814053
Intra SUMF2 Q8NBJ7 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
Intra SUMF2 Q8NBJ7 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
Intra SUMF2 Q8NBJ7 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
Intra SUMF2 Q8NBJ7 ap3a_sars2 SARS-CoV-2 P0DTC3
Y2H Array
36217030
Intra SUMF2 Q8NBJ7 IDS Homo sapiens P22304
Anti Tag CoIP
15962010
Intra SUMF2 Q8NBJ7 SUMF1 Homo sapiens Q8NBK3
Comig Non-Denat Gel
15962010
Intra SUMF2 Q8NBJ7 SUMF1 Homo sapiens Q8NBK3
Anti Tag CoIP
15962010
Intra SUMF2 Q8NBJ7 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra SUMF2 Q8NBJ7 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra SUMF2 Q8NBJ7 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra SUMF2 Q8NBJ7 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra SUMF2 Q8NBJ7 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra SUMF2 Q8NBJ7 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra SUMF2 Q8NBJ7 TTR Homo sapiens P02766
Y2H Pooling
32814053
Intra SUMF2 Q8NBJ7 TTR Homo sapiens P02766
Validated Y2H
32814053
Intra SUMF2 Q8NBJ7 TTR Homo sapiens P02766
Y2H Array
32814053
Intra SUMF2 Q8NBJ7 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra SUMF2 Q8NBJ7 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra SUMF2 Q8NBJ7 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra SUMF2 Q8NBJ7 ccsb_9919 Homo sapiens EBI-25847655
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Multiple Sulfatase Deficiency

Mucosulfatidosis

MSD

Sulfatidosis, Juvenile, Austin Type

Multiple Sulfatase Deficiency Disease

Juvenile Sulfatidosis, Austin Type

Juvenile Sulfatidosis

Sulfatidosis Juvenile, Austin Type

Austin Syndrome

Sulfatidosis Juvenile Austin Type

Sulfatase Deficiency, Multiple
Phosphoserine Phosphatase Deficiency

PSPHD

Deficiency Of Phosphoserine Phosphatase

Psph Deficiency

3-Phosphoserine Phosphatase Deficiency, Infantile/Juvenile Form

Psph Deficiency, Infantile/Juvenile Form

Deficiency, Phosphoserine Phosphatase
Serine Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14024 SUMF2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SUMF2 MGD MGI:1915152
Bos taurus SUMF2 VGNC VGNC:35472
Felis catus SUMF2 VGNC VGNC:80686
Rattus norvegicus SUMF2 RGD RGD:1563253
Macaca mulatta SUMF2 VGNC VGNC:78180
Canis familiaris SUMF2 VGNC VGNC:46983