2. Gene
  3. NCR3 - natural cytotoxicity triggering receptor 3 Gene

NCR3 - natural cytotoxicity triggering receptor 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as 1C7; MALS; CD337; LY117; NKp30

Gene ID: 259197 | Gene type: protein coding

About NCR3

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,588,895-31,593,006 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 590 orthologues, 14 paralogues and is associated with 1 phenotype. Broad expression in lymph node (RPKM 5.8), spleen (RPKM 4.7) and 18 other tissues.

Summary

The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

NCR3 Products(3)

mRNA Protein Name
NM_001145466.2 NP_001138938.1 natural cytotoxicity triggering receptor 3 isoform b precursor
NM_001145467.2 NP_001138939.1 natural cytotoxicity triggering receptor 3 isoform c precursor
NM_147130.3 NP_667341.1 natural cytotoxicity triggering receptor 3 isoform a precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
21444796 GOA
enables immune receptor activity IDA
IDA: Inferred from direct assay
15294952 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18055229 GOA
Biological Process GO Annotation Evidence Reference Source
involved in NK T cell activation IDA
IDA: Inferred from direct assay
15294952 GOA
involved in immune response-activating cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
18852879 GOA
involved in natural killer cell activation IDA
IDA: Inferred from direct assay
18852879 GOA
involved in positive regulation of natural killer cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
16304049 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in plasma membrane IDA
IDA: Inferred from direct assay
15294952 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCR3 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (19 - 127)

  • 0
  • 100
  • 201 a.a.
Protein Preferred Names Protein Names

natural cytotoxicity triggering receptor 3

NK-p30

NCR3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NCR3 O14931 LGALS3 Homo sapiens P17931
Anti Bait CoIP
25315772
Intra
NCR3 O14931 NCR3LG1 Homo sapiens Q68D85
SPR
21444796
Intra
NCR3 O14931 NCR3LG1 Homo sapiens Q68D85
SPR
19528259
Intra
NCR3 O14931 NCR3LG1 Homo sapiens Q68D85
SPR
21422170
Intra
NCR3 O14931 NCR3LG1 Homo sapiens Q68D85
FACS
22807449
Intra
NCR3 O14931 NCR3LG1 Homo sapiens Q68D85
X-Ray Diffraction
21422170
Intra
NCR3 O14931 NCR3LG1 Homo sapiens Q68D85
Crosslink
19528259
Intra
NCR3 O14931 NCR3LG1 Homo sapiens Q68D85
SPR
27754869
Intra
NCR3 O14931 NCR3LG1 Homo sapiens Q68D85
SPR
22807449
Intra
NCR3 O14931 NCR3 Homo sapiens O14931
EM
24275655
Intra
NCR3 O14931 NCR3 Homo sapiens O14931
GMS
24275655
Intra
NCR3 O14931 NCR3 Homo sapiens O14931
Electrophoresis
22807449
Intra
NCR3 O14931 NCR3 Homo sapiens O14931
X-Ray Diffraction
21444796
Intra
NCR3 O14931 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra
NCR3 O14931 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
NCR3 O14931 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
NCR3 O14931 BAG6 Homo sapiens P46379
ELISA
22807449
Intra
NCR3 O14931 BAG6 Homo sapiens P46379
ELISA
18852879
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NCR3 Proteins

Cat. No. Product Name Accession Purity
HY-P72506 NKp30/NCR3 Protein, Human (120a.a, HEK293, His) O14931-1 (L19-T138) ≥95%
HY-P77811 NKp30/NCR3 Protein, Human (120a.a, HEK293, Fc) O14931-1 (L19-T138) ≥95%
HY-P77812 NKp30/NCR3 Protein, Human (HEK293, His-Avi) O14931-1 (L19-T138) ≥95%
HY-P77813 NKp30/NCR3 Protein, Human (Biotinylated, HEK293, His-Avi) O14931-1 (L19-T138) ≥95%

Related Diseases

Diseases Alias
Malaria, Mild

Malaria, Mild, Susceptibility To

Mals

Mal

Xx Males

Karyotype 47,Xyy

Double Y Syndrome

Xyy Syndrome
Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria
Nk Cell Deficiency
Bronchiectasis 1
Gastrointestinal Stromal Tumor

GIST

Gastrointestinal Stromal Tumors

Gastrointestinal Stromal Sarcoma

Gastrointestinal Stromal Tumor, Familial

Gant

Gastrointestinal Stromal Tumour

Stromal Tumor Of Gastrointestinal Tract

Stromal Tumour Of Gastrointestinal Tract

Gastrointestinal Stromal Neoplasm

Paraganglioma And Gastric Stromal Sarcoma

Plexosarcoma
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09100 NCR3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS09101 NCR3LG1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta NCR3 VGNC VGNC:74990
Canis familiaris NCR3 VGNC VGNC:43666
Mus musculus NCR3 MGD MGI:2149332
Bos taurus NCR3 VGNC VGNC:31927
Rattus norvegicus NCR3 RGD RGD:727881
Macaca fascicularis NCR3 NCBI NCBI:102133932
Others NCR3 NCBI