BAG6 - BAG cochaperone 6 Gene

Homo sapiens

Also known as G3; BAT3; BAG-6; D6S52E

Gene ID: 7917 | Gene type: protein coding

About BAG6

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,639,028-31,652,661 (from NCBI)

This gene has 33 transcripts (splice variants), 1 gene allele and 242 orthologues. Broad expression in testis (RPKM 77.2), spleen (RPKM 25.1) and 25 other tissues.

Summary

This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by Caspase 3 and is implicated in the control of Apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

BAG6 Products(59)

mRNA	Protein	Name
NM_001098534.2	NP_001092004.1	large proline-rich protein BAG6 isoform 2
NM_001199697.2	NP_001186626.1	large proline-rich protein BAG6 isoform 3
NM_001199698.2	NP_001186627.1	large proline-rich protein BAG6 isoform 4
NM_001387940.1	NP_001374869.1	large proline-rich protein BAG6 isoform 4
NM_001387942.1	NP_001374871.1	large proline-rich protein BAG6 isoform 22
NM_001387943.1	NP_001374872.1	large proline-rich protein BAG6 isoform 20
NM_001387944.1	NP_001374873.1	large proline-rich protein BAG6 isoform 21
NM_001387946.1	NP_001374875.1	large proline-rich protein BAG6 isoform 20
NM_001387949.1	NP_001374878.1	large proline-rich protein BAG6 isoform 4
NM_001387951.1	NP_001374880.1	large proline-rich protein BAG6 isoform 25
NM_001387954.1	NP_001374883.1	large proline-rich protein BAG6 isoform 12
NM_001387955.1	NP_001374884.1	large proline-rich protein BAG6 isoform 19
NM_001387956.1	NP_001374885.1	large proline-rich protein BAG6 isoform 4
NM_001387958.1	NP_001374887.1	large proline-rich protein BAG6 isoform 18
NM_001387961.1	NP_001374890.1	large proline-rich protein BAG6 isoform 2
NM_001387963.1	NP_001374892.1	large proline-rich protein BAG6 isoform 15
NM_001387964.1	NP_001374893.1	large proline-rich protein BAG6 isoform 14
NM_001387965.1	NP_001374894.1	large proline-rich protein BAG6 isoform 12
NM_001387982.1	NP_001374911.1	large proline-rich protein BAG6 isoform 14
NM_001387983.1	NP_001374912.1	large proline-rich protein BAG6 isoform 13
NM_001387984.1	NP_001374913.1	large proline-rich protein BAG6 isoform 12
NM_001387985.1	NP_001374914.1	large proline-rich protein BAG6 isoform 11
NM_001387986.1	NP_001374915.1	large proline-rich protein BAG6 isoform 2
NM_001387987.1	NP_001374916.1	large proline-rich protein BAG6 isoform 10
NM_001387988.1	NP_001374917.1	large proline-rich protein BAG6 isoform 6
NM_001387989.1	NP_001374918.1	large proline-rich protein BAG6 isoform 5
NM_001387990.1	NP_001374919.1	large proline-rich protein BAG6 isoform 10
NM_001387991.1	NP_001374920.1	large proline-rich protein BAG6 isoform 7
NM_001387992.1	NP_001374921.1	large proline-rich protein BAG6 isoform 7
NM_001387993.1	NP_001374922.1	large proline-rich protein BAG6 isoform 6
NM_001387994.1	NP_001374923.1	large proline-rich protein BAG6 isoform 5
NM_001387995.1	NP_001374924.1	large proline-rich protein BAG6 isoform 6
NM_001387996.1	NP_001374925.1	large proline-rich protein BAG6 isoform 5
NM_001387997.1	NP_001374926.1	large proline-rich protein BAG6 isoform 21
NM_001387998.1	NP_001374927.1	large proline-rich protein BAG6 isoform 19
NM_001387999.1	NP_001374928.1	large proline-rich protein BAG6 isoform 4
NM_001388000.1	NP_001374929.1	large proline-rich protein BAG6 isoform 4
NM_001388001.1	NP_001374930.1	large proline-rich protein BAG6 isoform 4
NM_001388002.1	NP_001374931.1	large proline-rich protein BAG6 isoform 17
NM_001388003.1	NP_001374932.1	large proline-rich protein BAG6 isoform 16
NM_001388004.1	NP_001374933.1	large proline-rich protein BAG6 isoform 14
NM_001388005.1	NP_001374934.1	large proline-rich protein BAG6 isoform 13
NM_001388006.1	NP_001374935.1	large proline-rich protein BAG6 isoform 12
NM_001388007.1	NP_001374936.1	large proline-rich protein BAG6 isoform 10
NM_001388008.1	NP_001374937.1	large proline-rich protein BAG6 isoform 9
NM_001388009.1	NP_001374938.1	large proline-rich protein BAG6 isoform 8
NM_001388010.1	NP_001374939.1	large proline-rich protein BAG6 isoform 6
NM_001388011.1	NP_001374940.1	large proline-rich protein BAG6 isoform 5
NM_001388012.1	NP_001374941.1	large proline-rich protein BAG6 isoform 23
NM_001388013.1	NP_001374942.1	large proline-rich protein BAG6 isoform 24
NM_001388014.1	NP_001374943.1	large proline-rich protein BAG6 isoform 4
NM_001388015.1	NP_001374944.1	large proline-rich protein BAG6 isoform 2
NM_001388016.1	NP_001374945.1	large proline-rich protein BAG6 isoform 13
NM_001388017.1	NP_001374946.1	large proline-rich protein BAG6 isoform 2
NM_001388018.1	NP_001374947.1	large proline-rich protein BAG6 isoform 2
NM_001388019.1	NP_001374948.1	large proline-rich protein BAG6 isoform 6
NM_001388020.1	NP_001374949.1	large proline-rich protein BAG6 isoform 5
NM_080702.3	NP_542433.1	large proline-rich protein BAG6 isoform 2
NM_080703.3	NP_542434.1	large proline-rich protein BAG6 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	24133212	GOA
enables misfolded protein binding	IDA IDA: Inferred from direct assay	21636303	GOA
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	25713138	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14667819	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	18852879	GOA
enables ribosome binding	IDA IDA: Inferred from direct assay	20676083	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	18852879	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	21636303	GOA
enables ubiquitin-specific protease binding	IPI IPI: Inferred from physical interaction	24424410	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERAD pathway	IDA IDA: Inferred from direct assay	23129660	GOA
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	26565908	GOA
involved in NK T cell activation	IDA IDA: Inferred from direct assay	18852879	GOA
involved in apoptotic process	IDA IDA: Inferred from direct assay	14960581	GOA
involved in endoplasmic reticulum stress-induced pre-emptive quality control	IMP IMP: Inferred from mutant phenotype	26565908	GOA
involved in immune response-activating cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	18852879	GOA
involved in internal peptidyl-lysine acetylation	IDA IDA: Inferred from direct assay	17403783	GOA
involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP IMP: Inferred from mutant phenotype	17403783	GOA
involved in maintenance of unfolded protein	IMP IMP: Inferred from mutant phenotype	21636303	GOA
involved in natural killer cell activation	IDA IDA: Inferred from direct assay	18852879	GOA
involved in positive regulation of ERAD pathway	IMP IMP: Inferred from mutant phenotype	24424410	GOA
involved in post-translational protein targeting to endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	25535373	GOA
involved in proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	26565908	GOA
involved in regulation of protein stability	IDA IDA: Inferred from direct assay	21636303	GOA
involved in tail-anchored membrane protein insertion into ER membrane	IDA IDA: Inferred from direct assay	20676083	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	20676083	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of BAT3 complex	IDA IDA: Inferred from direct assay	20676083	GOA
part of BAT3 complex	IPI IPI: Inferred from physical interaction	25535373	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21636303	GOA
located in cytosol	IDA IDA: Inferred from direct assay	17403783	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	18852879	GOA
located in membrane	IDA IDA: Inferred from direct assay	23246001	GOA
located in nucleus	IDA IDA: Inferred from direct assay	14960581	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BAG6 Protein Structure

ubiquitin

DUF3538

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200
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1000
1126 a.a.

Protein Preferred Names

Protein Names

large proline-rich protein BAG6

BAG family molecular chaperone regulator 6

Related Diseases

Diseases

Alias

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01347	BAG6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BAG6	MGD	MGI:1919439
Macaca mulatta	BAG6	VGNC	VGNC:81044
Bos taurus	BAG6	VGNC	VGNC:26410
Rattus norvegicus	BAG6	RGD	RGD:71064
Canis familiaris	BAG6	VGNC	VGNC:38368
Felis catus	BAG6	VGNC	VGNC:60069

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