2. Gene
  3. SIN3A - SIN3 transcription regulator family member A Gene

SIN3A - SIN3 transcription regulator family member A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as WITKOS

Gene ID: 25942 | Gene type: protein coding

About SIN3A

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:75,369,379-75,455,815 (from NCBI)

This gene has 21 transcripts (splice variants), 274 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 15.9), thyroid (RPKM 12.9) and 25 other tissues.

Summary

The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]

SIN3A Products(3)

mRNA Protein Name
NM_001145357.2 NP_001138829.1 paired amphipathic helix protein Sin3a
NM_001145358.2 NP_001138830.1 paired amphipathic helix protein Sin3a
NM_015477.3 NP_056292.1 paired amphipathic helix protein Sin3a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
22783022 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9651585 GOA
enables transcription corepressor activity IMP
IMP: Inferred from mutant phenotype
22783022 GOA
enables transcription regulator inhibitor activity IDA
IDA: Inferred from direct assay
22783022 GOA
Biological Process GO Annotation Evidence Reference Source
involved in activation of innate immune response IMP
IMP: Inferred from mutant phenotype
22783022 GOA
involved in heterochromatin formation IMP
IMP: Inferred from mutant phenotype
22783022 GOA
involved in negative regulation of protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
22783022 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22783022 GOA
involved in positive regulation of defense response to virus by host IMP
IMP: Inferred from mutant phenotype
22783022 GOA
involved in type I interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
22783022 GOA
Cellular Component GO Annotation Evidence Reference Source
part of Sin3-type complex IDA
IDA: Inferred from direct assay
14966270 GOA
part of histone deacetylase complex IDA
IDA: Inferred from direct assay
9651585 GOA
located in nucleus IDA
IDA: Inferred from direct assay
22783022 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIN3A Protein Structure

PAH

PAH: Paired amphipathic helix repeat (141 - 187)

PAH

PAH: Paired amphipathic helix repeat (322 - 381)

PAH

PAH: Paired amphipathic helix repeat (478 - 522)

Sin3_corepress

Sin3_corepress: Sin3 family co-repressor (550 - 649)

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  • 1273 a.a.
Protein Preferred Names Protein Names

paired amphipathic helix protein Sin3a

SIN3 homolog A, transcription regulator

SIN3A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SIN3A Q96ST3 HDAC2 Homo sapiens Q92769
Anti Bait CoIP
25314079
Intra
SIN3A Q96ST3 HDAC2 Homo sapiens Q92769
Pull Down
16254079
Intra
SIN3A Q96ST3 HDAC1 Homo sapiens Q13547
Anti Tag CoIP
33961781
Intra
SIN3A Q96ST3 HDAC1 Homo sapiens Q13547
Anti Bait CoIP
25314079
Intra
SIN3A Q96ST3 HDAC1 Homo sapiens Q13547
Anti Bait CoIP
21258344
Intra
SIN3A Q96ST3 SKI Homo sapiens P12755
CoIP
14525983
Intra
SIN3A Q96ST3 SKI Homo sapiens P12755
Pull Down
10049357
Intra
SIN3A Q96ST3 SFPQ Homo sapiens P23246
Anti Bait CoIP
11259580
Intra
SIN3A Q96ST3 HCFC1 Homo sapiens P51610
Anti Bait CoIP
12670868
Intra
SIN3A Q96ST3 HCFC1 Homo sapiens P51610
Anti Tag CoIP
12670868
Intra
SIN3A Q96ST3 HCFC1 Homo sapiens P51610
Y2H
12670868
Intra
SIN3A Q96ST3 HTT Homo sapiens P42858
Pull Down
10823891
Intra
SIN3A Q96ST3 PA2G4 Homo sapiens Q9UQ80
Pull Down
16254079
Cross: Cross-species interaction Intra: Intraspecies interaction

SIN3A Antibodies

Cat. No. Product Name Application Reactivity
HY-P83623 mSin3A Antibody (YA3368) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Witteveen-Kolk Syndrome

WITKOS

Sin3a-Related Intellectual Disability Syndrome Due To A Point Mutation

Sin3a-Related Intellectual Disability Syndrome
Chromosome 15q24 Deletion Syndrome

15q24 Microdeletion Syndrome

Del(15)(Q24)

Monosomy 15q24

15q24 Microdeletion

15q24 Deletion

Interstitial Deletion Of Chromosome 15q24
Rett Syndrome

Atypical Rett Syndrome

RTT

Rett Disorder

Rts

Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use

Rett Syndrome, Preserved Speech Variant

Rett Syndrome, Atypical

Rett'S Disorder

Rett Syndrome Variant

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome

Cerebroatrophic Hyperammonemia

Rett Like Syndrome

Rett'S Syndrome

Atypical Rtt

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use

Rett Syndrome Preserved Speech Variant

Rett Syndrome Zappella Variant

Rett Syndrome, Zappella Variant
Gene Duplication Disease

Gene Duplication Syndrome
Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms
Uterine Corpus Endometrial Carcinoma
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
Polymicrogyria

Pmg
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P3242A Mad1 (6-21) TFA / Unkown
HY-RS12925 SIN3A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SIN3A VGNC VGNC:46177
Rattus norvegicus SIN3A RGD RGD:1311598
Felis catus SIN3A VGNC VGNC:65150
Macaca mulatta SIN3A VGNC VGNC:77275
Mus musculus SIN3A MGD MGI:107157
Bos taurus SIN3A VGNC VGNC:34624